Advanced

Analysis of the potential for non-invasive imaging of oxygenation at heart depth, using ultrasound optical tomography (UOT) or photo-acoustic tomography (PAT)

Walther, Andreas LU ; Rippe, Lars LU ; Wang, Lihong V.; Andersson-Engels, Stefan LU and Kröll, Stefan LU (2017) In Biomedical Optics Express 8(10). p.4523-4536
Abstract

Despite the important medical implications, it is currently an open task to find optical non-invasive techniques that can image deep organs in humans. Addressing this, photo-acoustic tomography (PAT) has received a great deal of attention in the past decade, owing to favorable properties like high contrast and high spatial resolution. However, even with optimal components PAT cannot penetrate beyond a few centimeters, which still presents an important limitation of the technique. Here, we calculate the absorption contrast levels for PAT and for ultrasound optical tomography (UOT) and compare them to their relevant noise sources as a function of imaging depth. The results indicate that a new development in optical filters, based on... (More)

Despite the important medical implications, it is currently an open task to find optical non-invasive techniques that can image deep organs in humans. Addressing this, photo-acoustic tomography (PAT) has received a great deal of attention in the past decade, owing to favorable properties like high contrast and high spatial resolution. However, even with optimal components PAT cannot penetrate beyond a few centimeters, which still presents an important limitation of the technique. Here, we calculate the absorption contrast levels for PAT and for ultrasound optical tomography (UOT) and compare them to their relevant noise sources as a function of imaging depth. The results indicate that a new development in optical filters, based on rare-earth-ion crystals, can push the UOT technique significantly ahead of PAT. Such filters allow the contrastto- noise ratio for UOT to be up to three orders of magnitude better than for PAT at depths of a few cm into the tissue. It also translates into a significant increase of the image depth of UOT compared to PAT, enabling deep organs to be imaged in humans in real time. Furthermore, such spectral holeburning filters are not sensitive to speckle decorrelation from the tissue and can operate at nearly any angle of incident light, allowing good light collection. We theoretically demonstrate the improved performance in the medically important case of non-invasive optical imaging of the oxygenation level of the frontal part of the human myocardial tissue. Our results indicate that further studies on UOT are of interest and that the technique may have large impact on future directions of biomedical optics.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
(110.0113) imaging through turbid media, (160.5690) rare-earth-doped materials, (170.3880) medical and biological imaging
in
Biomedical Optics Express
volume
8
issue
10
pages
14 pages
publisher
Optical Society of America
external identifiers
  • scopus:85030990777
  • wos:000412052000017
ISSN
2156-7085
DOI
10.1364/BOE.8.004523
language
English
LU publication?
yes
id
bae95e86-b31f-4d77-bf46-51dd36b5d948
date added to LUP
2017-10-26 15:25:54
date last changed
2018-10-30 20:24:50
@article{bae95e86-b31f-4d77-bf46-51dd36b5d948,
  abstract     = {<p>Despite the important medical implications, it is currently an open task to find optical non-invasive techniques that can image deep organs in humans. Addressing this, photo-acoustic tomography (PAT) has received a great deal of attention in the past decade, owing to favorable properties like high contrast and high spatial resolution. However, even with optimal components PAT cannot penetrate beyond a few centimeters, which still presents an important limitation of the technique. Here, we calculate the absorption contrast levels for PAT and for ultrasound optical tomography (UOT) and compare them to their relevant noise sources as a function of imaging depth. The results indicate that a new development in optical filters, based on rare-earth-ion crystals, can push the UOT technique significantly ahead of PAT. Such filters allow the contrastto- noise ratio for UOT to be up to three orders of magnitude better than for PAT at depths of a few cm into the tissue. It also translates into a significant increase of the image depth of UOT compared to PAT, enabling deep organs to be imaged in humans in real time. Furthermore, such spectral holeburning filters are not sensitive to speckle decorrelation from the tissue and can operate at nearly any angle of incident light, allowing good light collection. We theoretically demonstrate the improved performance in the medically important case of non-invasive optical imaging of the oxygenation level of the frontal part of the human myocardial tissue. Our results indicate that further studies on UOT are of interest and that the technique may have large impact on future directions of biomedical optics.</p>},
  articleno    = {#300815},
  author       = {Walther, Andreas and Rippe, Lars and Wang, Lihong V. and Andersson-Engels, Stefan and Kröll, Stefan},
  issn         = {2156-7085},
  keyword      = {(110.0113) imaging through turbid media,(160.5690) rare-earth-doped materials,(170.3880) medical and biological imaging},
  language     = {eng},
  month        = {10},
  number       = {10},
  pages        = {4523--4536},
  publisher    = {Optical Society of America},
  series       = {Biomedical Optics Express},
  title        = {Analysis of the potential for non-invasive imaging of oxygenation at heart depth, using ultrasound optical tomography (UOT) or photo-acoustic tomography (PAT)},
  url          = {http://dx.doi.org/10.1364/BOE.8.004523},
  volume       = {8},
  year         = {2017},
}