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Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort : A nested case-control study

Huang, Jiaqi; Zagai, Ulrika; Hallmans, Göran; Nyrén, Olof; Engstrand, Lars; Stolzenberg-Solomon, Rachael; Duell, Eric J; Overvad, Kim; Katzke, Verena A and Kaaks, Rudolf, et al. (2017) In International Journal of Cancer 140(8). p.1727-1735
Abstract

The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. Conditional logistic regression models were applied to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs), adjusted for matching factors and other potential confounders. Our results showed that pancreatic cancer risk was neither associated with H. pylori seropositivity (OR... (More)

The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. Conditional logistic regression models were applied to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs), adjusted for matching factors and other potential confounders. Our results showed that pancreatic cancer risk was neither associated with H. pylori seropositivity (OR = 0.96; 95% CI: 0.70, 1.31) nor CagA seropositivity (OR = 1.07; 95% CI: 0.77, 1.48). We also did not find any excess risk among individuals seropositive for H. pylori but seronegative for CagA, compared with the group seronegative for both antibodies (OR = 0.94; 95% CI: 0.63, 1.38). However, we found that chronic corpus atrophic gastritis was non-significantly associated with an increased pancreatic cancer risk (OR = 1.35; 95% CI: 0.77, 2.37), and although based on small numbers, the excess risk was particularly marked among individuals seronegative for both H. pylori and CagA (OR = 5.66; 95% CI: 1.59, 20.19, p value for interaction < 0.01). Our findings provided evidence supporting the null association between H. pylori infection and pancreatic cancer risk in western European populations. However, the suggested association between chronic corpus atrophic gastritis and pancreatic cancer risk warrants independent verification in future studies, and, if confirmed, further studies on the underlying mechanisms.

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keywords
chronic corpus atrophic gastritis, EPIC cohort, H. pylori infection, nested case-control study, pancreatic cancer risk
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International Journal of Cancer
volume
140
issue
8
pages
9 pages
publisher
John Wiley & Sons
external identifiers
  • scopus:85013381974
  • wos:000395181800002
ISSN
0020-7136
DOI
10.1002/ijc.30590
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English
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yes
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bafd527b-45e1-47c0-a249-ba540613416f
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2017-03-13 08:22:46
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2018-02-18 04:58:00
@article{bafd527b-45e1-47c0-a249-ba540613416f,
  abstract     = {<p>The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. Conditional logistic regression models were applied to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs), adjusted for matching factors and other potential confounders. Our results showed that pancreatic cancer risk was neither associated with H. pylori seropositivity (OR = 0.96; 95% CI: 0.70, 1.31) nor CagA seropositivity (OR = 1.07; 95% CI: 0.77, 1.48). We also did not find any excess risk among individuals seropositive for H. pylori but seronegative for CagA, compared with the group seronegative for both antibodies (OR = 0.94; 95% CI: 0.63, 1.38). However, we found that chronic corpus atrophic gastritis was non-significantly associated with an increased pancreatic cancer risk (OR = 1.35; 95% CI: 0.77, 2.37), and although based on small numbers, the excess risk was particularly marked among individuals seronegative for both H. pylori and CagA (OR = 5.66; 95% CI: 1.59, 20.19, p value for interaction &lt; 0.01). Our findings provided evidence supporting the null association between H. pylori infection and pancreatic cancer risk in western European populations. However, the suggested association between chronic corpus atrophic gastritis and pancreatic cancer risk warrants independent verification in future studies, and, if confirmed, further studies on the underlying mechanisms.</p>},
  author       = {Huang, Jiaqi and Zagai, Ulrika and Hallmans, Göran and Nyrén, Olof and Engstrand, Lars and Stolzenberg-Solomon, Rachael and Duell, Eric J and Overvad, Kim and Katzke, Verena A and Kaaks, Rudolf and Jenab, Mazda and Park, Jin Young and Murillo, Raul and Trichopoulou, Antonia and Lagiou, Pagona and Bamia, Christina and Bradbury, Kathryn E and Riboli, Elio and Aune, Dagfinn and Tsilidis, Konstantinos K. and Capellá, Gabriel and Agudo, Antonio and Krogh, Vittorio and Palli, Domenico and Panico, Salvatore and Weiderpass, Elisabete and Tjønneland, Anne and Olsen, Anja and Martínez, Begoña and Redondo-Sanchez, Daniel and Chirlaque, Maria Dolores and HM Peeters, Petra and Regnér, Sara and Lindkvist, Björn and Naccarati, Alessio and Ardanaz, Eva and Larrañaga, Nerea and Boutron-Ruault, Marie-Christine and Rebours, Vinciane and Barré, Amélie and Bueno-De-Mesquita, Bas H. and Ye, Weimin},
  issn         = {0020-7136},
  keyword      = {chronic corpus atrophic gastritis,EPIC cohort,H. pylori infection,nested case-control study,pancreatic cancer risk},
  language     = {eng},
  month        = {04},
  number       = {8},
  pages        = {1727--1735},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort : A nested case-control study},
  url          = {http://dx.doi.org/10.1002/ijc.30590},
  volume       = {140},
  year         = {2017},
}