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Effects of DPP-4 inhibitor linagliptin and GLP-1 receptor agonist liraglutide on physiological response to hypoglycaemia in Japanese subjects with type 2 diabetes : A randomized, open-label, 2-arm parallel comparative, exploratory trial

Yabe, Daisuke; Eto, Takashi; Shiramoto, Masanari; Irie, Shin; Murotani, Kenta; Seino, Yusuke; Kuwata, Hitoshi; Kurose, Takeshi; Seino, Susumu and Ahrén, Bo LU , et al. (2017) In Diabetes, Obesity and Metabolism 19(3). p.442-447
Abstract

Dipeptidyl peptidase-4 (DPP-4) inhibitors reduce the risk of hypoglycaemia, possibly through augmentation of glucose-dependent insulinotropic polypeptide (GIP) action, but not that of glucagon-like peptide-1 (GLP-1) on glucagon secretion. To examine this model in Japanese individuals with type 2 diabetes (T2D), the effects of the DPP-4 inhibitor linagliptin on glucagon and other counter-regulatory hormone responses to hypoglycaemia were evaluated and compared with those of the GLP-1 receptor agonist liraglutide in a multi-centre, randomized, open-label, 2-arm parallel comparative, exploratory trial. Three-step hypoglycaemic clamp glucose tests preceded by meal tolerance tests were performed before and after 2-week treatment with the... (More)

Dipeptidyl peptidase-4 (DPP-4) inhibitors reduce the risk of hypoglycaemia, possibly through augmentation of glucose-dependent insulinotropic polypeptide (GIP) action, but not that of glucagon-like peptide-1 (GLP-1) on glucagon secretion. To examine this model in Japanese individuals with type 2 diabetes (T2D), the effects of the DPP-4 inhibitor linagliptin on glucagon and other counter-regulatory hormone responses to hypoglycaemia were evaluated and compared with those of the GLP-1 receptor agonist liraglutide in a multi-centre, randomized, open-label, 2-arm parallel comparative, exploratory trial. Three-step hypoglycaemic clamp glucose tests preceded by meal tolerance tests were performed before and after 2-week treatment with the drugs. Glucagon levels were increased during the hypoglycaemic clamp test at 2.5mmol/L. This increase was similar in the linagliptin and liraglutide groups, both before and after the 2-week treatment. Changes in other counter-regulatory hormones (ie, growth hormone, cortisol, epinephrine and norepinephrine) were also similar between the groups, but were suppressed substantially after 2-week treatment compared to baseline. In conclusion, we confirmed that the glucagon response to hypoglycaemia was not affected by linagliptin or liraglutide treatment in Japanese individuals with T2D.

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publication status
published
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keywords
GLP-1 receptor agonist, DPP-4 inhibitor, Glucagon response, Hypoglycaemia, Sympatho-adrenal response
in
Diabetes, Obesity and Metabolism
volume
19
issue
3
pages
442 - 447
publisher
Wiley-Blackwell
external identifiers
  • scopus:85006240253
  • wos:000394785200016
ISSN
1462-8902
DOI
10.1111/dom.12817
language
English
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yes
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bba07c02-b3a6-457f-b691-61417c54ca63
date added to LUP
2017-01-20 14:59:51
date last changed
2018-01-07 11:45:58
@article{bba07c02-b3a6-457f-b691-61417c54ca63,
  abstract     = {<p>Dipeptidyl peptidase-4 (DPP-4) inhibitors reduce the risk of hypoglycaemia, possibly through augmentation of glucose-dependent insulinotropic polypeptide (GIP) action, but not that of glucagon-like peptide-1 (GLP-1) on glucagon secretion. To examine this model in Japanese individuals with type 2 diabetes (T2D), the effects of the DPP-4 inhibitor linagliptin on glucagon and other counter-regulatory hormone responses to hypoglycaemia were evaluated and compared with those of the GLP-1 receptor agonist liraglutide in a multi-centre, randomized, open-label, 2-arm parallel comparative, exploratory trial. Three-step hypoglycaemic clamp glucose tests preceded by meal tolerance tests were performed before and after 2-week treatment with the drugs. Glucagon levels were increased during the hypoglycaemic clamp test at 2.5mmol/L. This increase was similar in the linagliptin and liraglutide groups, both before and after the 2-week treatment. Changes in other counter-regulatory hormones (ie, growth hormone, cortisol, epinephrine and norepinephrine) were also similar between the groups, but were suppressed substantially after 2-week treatment compared to baseline. In conclusion, we confirmed that the glucagon response to hypoglycaemia was not affected by linagliptin or liraglutide treatment in Japanese individuals with T2D.</p>},
  author       = {Yabe, Daisuke and Eto, Takashi and Shiramoto, Masanari and Irie, Shin and Murotani, Kenta and Seino, Yusuke and Kuwata, Hitoshi and Kurose, Takeshi and Seino, Susumu and Ahrén, Bo and Seino, Yutaka},
  issn         = {1462-8902},
  keyword      = {GLP-1 receptor agonist,DPP-4 inhibitor,Glucagon response,Hypoglycaemia,Sympatho-adrenal response},
  language     = {eng},
  number       = {3},
  pages        = {442--447},
  publisher    = {Wiley-Blackwell},
  series       = {Diabetes, Obesity and Metabolism},
  title        = {Effects of DPP-4 inhibitor linagliptin and GLP-1 receptor agonist liraglutide on physiological response to hypoglycaemia in Japanese subjects with type 2 diabetes : A randomized, open-label, 2-arm parallel comparative, exploratory trial},
  url          = {http://dx.doi.org/10.1111/dom.12817},
  volume       = {19},
  year         = {2017},
}