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The association between dietary intake, lifestyle and incident symptomatic peripheral arterial disease among individuals with diabetes mellitus : insights from the Malmö Diet and Cancer study

Lilja, Erika LU orcid ; Bergwall, Sara LU ; Sonestedt, Emily LU orcid ; Gottsäter, Anders LU and Acosta, Stefan LU orcid (2019) In Therapeutic Advances in Endocrinology and Metabolism 10. p.1-8
Abstract

With the rising prevalence of both diabetes mellitus (DM) and peripheral arterial disease (PAD), the aim of this project was to examine the association between dietary intake and lifestyle on the risk of developing PAD among individuals with DM. The Malmö Diet and Cancer study was a prospective cohort study with baseline examinations carried out between 1991 and 1996 in Malmö, Sweden (n = 30,446). Individuals with prevalent PAD and cardiovascular disease (prior stroke or myocardial infarction) were excluded from the study, resulting in a total study population of 1112 patients with prevalent DM. The diagnosis of incident PAD was validated and confirmed in 98% of patients. Of the 1112 individuals, 136 (12.2%) were diagnosed with PAD... (More)

With the rising prevalence of both diabetes mellitus (DM) and peripheral arterial disease (PAD), the aim of this project was to examine the association between dietary intake and lifestyle on the risk of developing PAD among individuals with DM. The Malmö Diet and Cancer study was a prospective cohort study with baseline examinations carried out between 1991 and 1996 in Malmö, Sweden (n = 30,446). Individuals with prevalent PAD and cardiovascular disease (prior stroke or myocardial infarction) were excluded from the study, resulting in a total study population of 1112 patients with prevalent DM. The diagnosis of incident PAD was validated and confirmed in 98% of patients. Of the 1112 individuals, 136 (12.2%) were diagnosed with PAD during a median follow up of 19.7 years (interquartile range 12.9–22.4). Kaplan–Meier analysis showed that men with DM more often developed incident PAD compared with women (cumulative incidences 15.5% and 8.9%, respectively, p = 0.012). In Cox multivariable regression analysis, smoking (hazard ratio of 1.96, 95% confidence interval of 1.28–3.00) was associated with increased risk of PAD, and there was a trend that a higher intake of fish and shellfish (hazard ratio per additional gram per week of 0.99, 95% confidence interval of 0.99–1.00; p = 0.051) was associated with a decreased risk of PAD. In conclusion, the present study demonstrated a trend towards a protective effect of higher intake of fish and shellfish upon incident symptomatic PAD among individuals with DM.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
diabetes mellitus, diet, fish and shellfish, incident peripheral arterial disease
in
Therapeutic Advances in Endocrinology and Metabolism
volume
10
pages
1 - 8
publisher
SAGE Publications
external identifiers
  • pmid:31839923
  • scopus:85076291280
ISSN
2042-0188
DOI
10.1177/2042018819890532
language
English
LU publication?
yes
id
bbaf2426-90db-477e-9394-af041bd397e1
date added to LUP
2020-04-20 12:52:32
date last changed
2024-02-16 14:33:47
@article{bbaf2426-90db-477e-9394-af041bd397e1,
  abstract     = {{<p>With the rising prevalence of both diabetes mellitus (DM) and peripheral arterial disease (PAD), the aim of this project was to examine the association between dietary intake and lifestyle on the risk of developing PAD among individuals with DM. The Malmö Diet and Cancer study was a prospective cohort study with baseline examinations carried out between 1991 and 1996 in Malmö, Sweden (n = 30,446). Individuals with prevalent PAD and cardiovascular disease (prior stroke or myocardial infarction) were excluded from the study, resulting in a total study population of 1112 patients with prevalent DM. The diagnosis of incident PAD was validated and confirmed in 98% of patients. Of the 1112 individuals, 136 (12.2%) were diagnosed with PAD during a median follow up of 19.7 years (interquartile range 12.9–22.4). Kaplan–Meier analysis showed that men with DM more often developed incident PAD compared with women (cumulative incidences 15.5% and 8.9%, respectively, p = 0.012). In Cox multivariable regression analysis, smoking (hazard ratio of 1.96, 95% confidence interval of 1.28–3.00) was associated with increased risk of PAD, and there was a trend that a higher intake of fish and shellfish (hazard ratio per additional gram per week of 0.99, 95% confidence interval of 0.99–1.00; p = 0.051) was associated with a decreased risk of PAD. In conclusion, the present study demonstrated a trend towards a protective effect of higher intake of fish and shellfish upon incident symptomatic PAD among individuals with DM.</p>}},
  author       = {{Lilja, Erika and Bergwall, Sara and Sonestedt, Emily and Gottsäter, Anders and Acosta, Stefan}},
  issn         = {{2042-0188}},
  keywords     = {{diabetes mellitus; diet; fish and shellfish; incident peripheral arterial disease}},
  language     = {{eng}},
  pages        = {{1--8}},
  publisher    = {{SAGE Publications}},
  series       = {{Therapeutic Advances in Endocrinology and Metabolism}},
  title        = {{The association between dietary intake, lifestyle and incident symptomatic peripheral arterial disease among individuals with diabetes mellitus : insights from the Malmö Diet and Cancer study}},
  url          = {{http://dx.doi.org/10.1177/2042018819890532}},
  doi          = {{10.1177/2042018819890532}},
  volume       = {{10}},
  year         = {{2019}},
}