Once-weekly oral medication with alendronate does not prevent migration of knee prostheses
(2009) In Acta Orthopaedica 80(1). p.41-45- Abstract
- Background and purpose Early migration of joint replacements is an effect of poor fixation and can predict late loosening. By reducing the bone resorption after implantation of a joint replacement, it should be possible to enhance the initial fixation of the implant. We studied the effect of once-weekly treatment with alendronate after knee replacement. Patients and methods We recruited 60 patients (60 knees) with gonarthrosis who were scheduled for a total knee replacement. They were operated on with identical implants and uncemented fixation. 30 patients were treated with a bisphosphonate (alendronate) and 30 patients underwent placebo treatment. The treatment started postoperatively and continued on a weekly basis for 6 months. The... (More)
- Background and purpose Early migration of joint replacements is an effect of poor fixation and can predict late loosening. By reducing the bone resorption after implantation of a joint replacement, it should be possible to enhance the initial fixation of the implant. We studied the effect of once-weekly treatment with alendronate after knee replacement. Patients and methods We recruited 60 patients (60 knees) with gonarthrosis who were scheduled for a total knee replacement. They were operated on with identical implants and uncemented fixation. 30 patients were treated with a bisphosphonate (alendronate) and 30 patients underwent placebo treatment. The treatment started postoperatively and continued on a weekly basis for 6 months. The fixation of the implants was measured with repeated radiostereometry for 2 years. Results There was no difference in migration of implants between the two groups. Conclusion With uncemented fixation of knee implants, no benefit of once-weekly treatment with alendronate, starting postoperatively, could be seen during a 2-year follow-up period. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1402436
- author
- Hansson, Ulrik LU ; Toksvig-Larsen, Sören LU ; Ryd, Leif LU and Aspenberg, Per LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Osteoarthritis, Knee: surgery, Bone Resorption: radiography, Bone Remodeling: drug effects, Bone Density Conservation Agents: administration & dosage, Bone Density: drug effects, Alendronate: administration & dosage, Knee: adverse effects, Replacement, Arthroplasty
- in
- Acta Orthopaedica
- volume
- 80
- issue
- 1
- pages
- 41 - 45
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000264347300009
- pmid:19297788
- scopus:61649126840
- ISSN
- 1745-3682
- DOI
- 10.1080/17453670902804968
- language
- English
- LU publication?
- yes
- id
- bbd22423-ddc6-46de-894b-30bd4bb8395a (old id 1402436)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19297788?dopt=Abstract
- date added to LUP
- 2016-04-01 11:39:44
- date last changed
- 2022-01-26 08:22:27
@article{bbd22423-ddc6-46de-894b-30bd4bb8395a,
abstract = {{Background and purpose Early migration of joint replacements is an effect of poor fixation and can predict late loosening. By reducing the bone resorption after implantation of a joint replacement, it should be possible to enhance the initial fixation of the implant. We studied the effect of once-weekly treatment with alendronate after knee replacement. Patients and methods We recruited 60 patients (60 knees) with gonarthrosis who were scheduled for a total knee replacement. They were operated on with identical implants and uncemented fixation. 30 patients were treated with a bisphosphonate (alendronate) and 30 patients underwent placebo treatment. The treatment started postoperatively and continued on a weekly basis for 6 months. The fixation of the implants was measured with repeated radiostereometry for 2 years. Results There was no difference in migration of implants between the two groups. Conclusion With uncemented fixation of knee implants, no benefit of once-weekly treatment with alendronate, starting postoperatively, could be seen during a 2-year follow-up period.}},
author = {{Hansson, Ulrik and Toksvig-Larsen, Sören and Ryd, Leif and Aspenberg, Per}},
issn = {{1745-3682}},
keywords = {{Osteoarthritis; Knee: surgery; Bone Resorption: radiography; Bone Remodeling: drug effects; Bone Density Conservation Agents: administration & dosage; Bone Density: drug effects; Alendronate: administration & dosage; Knee: adverse effects; Replacement; Arthroplasty}},
language = {{eng}},
number = {{1}},
pages = {{41--45}},
publisher = {{Taylor & Francis}},
series = {{Acta Orthopaedica}},
title = {{Once-weekly oral medication with alendronate does not prevent migration of knee prostheses}},
url = {{http://dx.doi.org/10.1080/17453670902804968}},
doi = {{10.1080/17453670902804968}},
volume = {{80}},
year = {{2009}},
}