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Sorting breast cancer cells based on deformability

Tran, Si Hoai Trung LU ; Ho, Bao Dang LU ; Holm, Stefan LU ; Beech, Jason P. LU and Tegenfeldt, Jonas O. LU (2015) 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences p.364-366
Abstract

Due to their direct coupling to the physiology of the cells, the physical properties are especially attractive as markers for sorting and characterization of cancer cells. Where molecular surface markers are lacking, the physical properties can instead serve as inherent markers for separation. This is especially interesting for cancer cells where there are indications that soft cells are more metastatic than hard cells. Our work is expected to provide a deeper understanding of deformability based sorting based on deterministic lateral displacement (DLD). This will subsequently be used to optimize DLD devices for characterization and fractionation of cancer cells into subpopulations of different mechanical properties. Our aim is to... (More)

Due to their direct coupling to the physiology of the cells, the physical properties are especially attractive as markers for sorting and characterization of cancer cells. Where molecular surface markers are lacking, the physical properties can instead serve as inherent markers for separation. This is especially interesting for cancer cells where there are indications that soft cells are more metastatic than hard cells. Our work is expected to provide a deeper understanding of deformability based sorting based on deterministic lateral displacement (DLD). This will subsequently be used to optimize DLD devices for characterization and fractionation of cancer cells into subpopulations of different mechanical properties. Our aim is to develop a device to help oncologists gain more accurate prognoses and better monitoring of the effect of treatment.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Cancer, Cell mechanics, Deterministic lateral displacement
in
MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
pages
3 pages
publisher
Chemical and Biological Microsystems Society
conference name
19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
external identifiers
  • scopus:84983335728
ISBN
9780979806483
language
English
LU publication?
yes
id
bc10a6f7-e1c9-4ddd-a6c4-dc9eb12aac9b
date added to LUP
2016-12-21 09:58:28
date last changed
2017-01-01 08:44:07
@inproceedings{bc10a6f7-e1c9-4ddd-a6c4-dc9eb12aac9b,
  abstract     = {<p>Due to their direct coupling to the physiology of the cells, the physical properties are especially attractive as markers for sorting and characterization of cancer cells. Where molecular surface markers are lacking, the physical properties can instead serve as inherent markers for separation. This is especially interesting for cancer cells where there are indications that soft cells are more metastatic than hard cells. Our work is expected to provide a deeper understanding of deformability based sorting based on deterministic lateral displacement (DLD). This will subsequently be used to optimize DLD devices for characterization and fractionation of cancer cells into subpopulations of different mechanical properties. Our aim is to develop a device to help oncologists gain more accurate prognoses and better monitoring of the effect of treatment.</p>},
  author       = {Tran, Si Hoai Trung and Ho, Bao Dang and Holm, Stefan and Beech, Jason P. and Tegenfeldt, Jonas O.},
  booktitle    = {MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences},
  isbn         = {9780979806483},
  keyword      = {Cancer,Cell mechanics,Deterministic lateral displacement},
  language     = {eng},
  pages        = {364--366},
  publisher    = {Chemical and Biological Microsystems Society},
  title        = {Sorting breast cancer cells based on deformability},
  year         = {2015},
}