Sorting breast cancer cells based on deformability
(2015) 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 p.364-366- Abstract
Due to their direct coupling to the physiology of the cells, the physical properties are especially attractive as markers for sorting and characterization of cancer cells. Where molecular surface markers are lacking, the physical properties can instead serve as inherent markers for separation. This is especially interesting for cancer cells where there are indications that soft cells are more metastatic than hard cells. Our work is expected to provide a deeper understanding of deformability based sorting based on deterministic lateral displacement (DLD). This will subsequently be used to optimize DLD devices for characterization and fractionation of cancer cells into subpopulations of different mechanical properties. Our aim is to... (More)
Due to their direct coupling to the physiology of the cells, the physical properties are especially attractive as markers for sorting and characterization of cancer cells. Where molecular surface markers are lacking, the physical properties can instead serve as inherent markers for separation. This is especially interesting for cancer cells where there are indications that soft cells are more metastatic than hard cells. Our work is expected to provide a deeper understanding of deformability based sorting based on deterministic lateral displacement (DLD). This will subsequently be used to optimize DLD devices for characterization and fractionation of cancer cells into subpopulations of different mechanical properties. Our aim is to develop a device to help oncologists gain more accurate prognoses and better monitoring of the effect of treatment.
(Less)
- author
- Tran, Si Hoai Trung
LU
; Ho, Bao Dang
LU
; Holm, Stefan
LU
; Beech, Jason P.
LU
and Tegenfeldt, Jonas O.
LU
- organization
- publishing date
- 2015
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Cancer, Cell mechanics, Deterministic lateral displacement
- host publication
- MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
- pages
- 3 pages
- publisher
- Chemical and Biological Microsystems Society
- conference name
- 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
- conference location
- Gyeongju, Korea, Republic of
- conference dates
- 2015-10-25 - 2015-10-29
- external identifiers
-
- scopus:84983335728
- ISBN
- 9780979806483
- language
- English
- LU publication?
- yes
- id
- bc10a6f7-e1c9-4ddd-a6c4-dc9eb12aac9b
- date added to LUP
- 2016-12-21 09:58:28
- date last changed
- 2022-01-30 08:43:24
@inproceedings{bc10a6f7-e1c9-4ddd-a6c4-dc9eb12aac9b, abstract = {{<p>Due to their direct coupling to the physiology of the cells, the physical properties are especially attractive as markers for sorting and characterization of cancer cells. Where molecular surface markers are lacking, the physical properties can instead serve as inherent markers for separation. This is especially interesting for cancer cells where there are indications that soft cells are more metastatic than hard cells. Our work is expected to provide a deeper understanding of deformability based sorting based on deterministic lateral displacement (DLD). This will subsequently be used to optimize DLD devices for characterization and fractionation of cancer cells into subpopulations of different mechanical properties. Our aim is to develop a device to help oncologists gain more accurate prognoses and better monitoring of the effect of treatment.</p>}}, author = {{Tran, Si Hoai Trung and Ho, Bao Dang and Holm, Stefan and Beech, Jason P. and Tegenfeldt, Jonas O.}}, booktitle = {{MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences}}, isbn = {{9780979806483}}, keywords = {{Cancer; Cell mechanics; Deterministic lateral displacement}}, language = {{eng}}, pages = {{364--366}}, publisher = {{Chemical and Biological Microsystems Society}}, title = {{Sorting breast cancer cells based on deformability}}, year = {{2015}}, }