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Peptide interactions with bacterial lipopolysaccharides

Schmidtchen, Artur LU and Malmsten, Martin (2013) In Current Opinion in Colloid & Interface Science 18(5). p.381-392
Abstract
Peptide and protein interactions with (lipo)polysaccharides are important in various biological contexts, including lipoprotein deposition at proteoglycan-covered endothelial surfaces in atherosclerosis, lectin functionality, and the interaction of antimicrobial and anti-inflammatory peptides and proteins with (lipo)polysaccharides. The latter of these areas, which is the topic of this review, has attracted considerable interest during the last few years, since antimicrobial peptides may offer novel therapeutic opportunities in an era of growing problems with antibiotic resistance, and persisting problems with both acute and chronic inflammation. In the present overview, physicochemical factors affecting peptide interactions with bacterial... (More)
Peptide and protein interactions with (lipo)polysaccharides are important in various biological contexts, including lipoprotein deposition at proteoglycan-covered endothelial surfaces in atherosclerosis, lectin functionality, and the interaction of antimicrobial and anti-inflammatory peptides and proteins with (lipo)polysaccharides. The latter of these areas, which is the topic of this review, has attracted considerable interest during the last few years, since antimicrobial peptides may offer novel therapeutic opportunities in an era of growing problems with antibiotic resistance, and persisting problems with both acute and chronic inflammation. In the present overview, physicochemical factors affecting peptide interactions with bacterial (lipo)polysaccharides are discussed, both in solution and at membrane interfaces. In doing so, an attempt is made to illustrate how physicochemical factors affect the antimicrobial and anti-endotoxic functionality of such peptides, and how knowledge on this can be translated into therapeutic opportunities, e.g., in sepsis. (C) 2013 Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anti-endotoxic, Antimicrobial, Lipid A, Lipopolysaccharide, Peptide
in
Current Opinion in Colloid & Interface Science
volume
18
issue
5
pages
381 - 392
publisher
Elsevier
external identifiers
  • wos:000324356400002
  • scopus:84882236345
ISSN
1359-0294
DOI
10.1016/j.cocis.2013.06.003
language
English
LU publication?
yes
id
bc1c478f-9145-4098-8400-97e805c76ae9 (old id 4102057)
date added to LUP
2016-04-01 12:51:42
date last changed
2019-12-04 02:42:20
@article{bc1c478f-9145-4098-8400-97e805c76ae9,
  abstract     = {Peptide and protein interactions with (lipo)polysaccharides are important in various biological contexts, including lipoprotein deposition at proteoglycan-covered endothelial surfaces in atherosclerosis, lectin functionality, and the interaction of antimicrobial and anti-inflammatory peptides and proteins with (lipo)polysaccharides. The latter of these areas, which is the topic of this review, has attracted considerable interest during the last few years, since antimicrobial peptides may offer novel therapeutic opportunities in an era of growing problems with antibiotic resistance, and persisting problems with both acute and chronic inflammation. In the present overview, physicochemical factors affecting peptide interactions with bacterial (lipo)polysaccharides are discussed, both in solution and at membrane interfaces. In doing so, an attempt is made to illustrate how physicochemical factors affect the antimicrobial and anti-endotoxic functionality of such peptides, and how knowledge on this can be translated into therapeutic opportunities, e.g., in sepsis. (C) 2013 Elsevier Ltd. All rights reserved.},
  author       = {Schmidtchen, Artur and Malmsten, Martin},
  issn         = {1359-0294},
  language     = {eng},
  number       = {5},
  pages        = {381--392},
  publisher    = {Elsevier},
  series       = {Current Opinion in Colloid & Interface Science},
  title        = {Peptide interactions with bacterial lipopolysaccharides},
  url          = {https://lup.lub.lu.se/search/ws/files/3018764/4255150.pdf},
  doi          = {10.1016/j.cocis.2013.06.003},
  volume       = {18},
  year         = {2013},
}