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Impact of Di-2-Ethylhexyl Phthalate Metabolites on Male Reproductive Function : a Systematic Review of Human Evidence

Høyer, Birgit Bjerre ; Lenters, Virissa ; Giwercman, Aleksander LU ; Jönsson, Bo A.G. LU ; Toft, Gunnar ; Hougaard, Karin S. ; Bonde, Jens Peter E. and Specht, Ina Olmer (2018) In Current Environmental Health Reports 5(1). p.20-33
Abstract

PURPOSE OF REVIEW: The purpose of this review is to systematically review the literature linking di-2-ethylhexyl phthalate (DEHP) exposure with effects on reproductive health in adult males. RECENT FINDINGS: Thirty-three papers were included of which 28 were cross-sectional. Twenty-one papers investigated semen samples, 18 investigated reproductive hormones, and three studies investigated time to pregnancy. Studies revealed some but inconsistent indications that higher urinary DEHP metabolite levels are associated with an increase in the proportion of spermatozoa with damaged DNA and to a decrease in sperm concentration and motility. A negative association between DEHP metabolites and testosterone levels was more consistent. DEHP... (More)

PURPOSE OF REVIEW: The purpose of this review is to systematically review the literature linking di-2-ethylhexyl phthalate (DEHP) exposure with effects on reproductive health in adult males. RECENT FINDINGS: Thirty-three papers were included of which 28 were cross-sectional. Twenty-one papers investigated semen samples, 18 investigated reproductive hormones, and three studies investigated time to pregnancy. Studies revealed some but inconsistent indications that higher urinary DEHP metabolite levels are associated with an increase in the proportion of spermatozoa with damaged DNA and to a decrease in sperm concentration and motility. A negative association between DEHP metabolites and testosterone levels was more consistent. DEHP metabolites do not seem to be associated with a delay in time to pregnancy, but data are sparse. The studies on DEHP exposure and reproductive biomarkers in men converge to support the hypothesis that DEHP exposure is related to impaired male reproductive function. Longitudinal studies are needed to establish if the observed associations are causal.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Fecundity, Gonadal steroid hormones, Phthalic acids, Reproduction, Review, Semen quality
in
Current Environmental Health Reports
volume
5
issue
1
pages
14 pages
publisher
Springer
external identifiers
  • pmid:29468520
  • scopus:85055035127
ISSN
2196-5412
DOI
10.1007/s40572-018-0174-3
language
English
LU publication?
yes
id
bc2df7ed-1708-4a38-9eaf-f6a60e307aa3
date added to LUP
2019-05-21 21:13:08
date last changed
2021-02-23 04:33:28
@article{bc2df7ed-1708-4a38-9eaf-f6a60e307aa3,
  abstract     = {<p>PURPOSE OF REVIEW: The purpose of this review is to systematically review the literature linking di-2-ethylhexyl phthalate (DEHP) exposure with effects on reproductive health in adult males. RECENT FINDINGS: Thirty-three papers were included of which 28 were cross-sectional. Twenty-one papers investigated semen samples, 18 investigated reproductive hormones, and three studies investigated time to pregnancy. Studies revealed some but inconsistent indications that higher urinary DEHP metabolite levels are associated with an increase in the proportion of spermatozoa with damaged DNA and to a decrease in sperm concentration and motility. A negative association between DEHP metabolites and testosterone levels was more consistent. DEHP metabolites do not seem to be associated with a delay in time to pregnancy, but data are sparse. The studies on DEHP exposure and reproductive biomarkers in men converge to support the hypothesis that DEHP exposure is related to impaired male reproductive function. Longitudinal studies are needed to establish if the observed associations are causal.</p>},
  author       = {Høyer, Birgit Bjerre and Lenters, Virissa and Giwercman, Aleksander and Jönsson, Bo A.G. and Toft, Gunnar and Hougaard, Karin S. and Bonde, Jens Peter E. and Specht, Ina Olmer},
  issn         = {2196-5412},
  language     = {eng},
  month        = {03},
  number       = {1},
  pages        = {20--33},
  publisher    = {Springer},
  series       = {Current Environmental Health Reports},
  title        = {Impact of Di-2-Ethylhexyl Phthalate Metabolites on Male Reproductive Function : a Systematic Review of Human Evidence},
  url          = {http://dx.doi.org/10.1007/s40572-018-0174-3},
  doi          = {10.1007/s40572-018-0174-3},
  volume       = {5},
  year         = {2018},
}