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Mortality patterns in long-term survivors of childhood or adolescent central nervous system tumour in Sweden

Huang, Wuqing LU orcid ; Sundquist, Jan LU ; Sundquist, Kristina LU and Ji, Jianguang LU orcid (2019) In Journal of Neuro-Oncology 145(3). p.541-549
Abstract

PURPOSE: A growing number of young patients with central nervous system (CNS) tumour survived for more than five years. However, these long-term survivors might be at risk of multiple late effects thus leading to a higher risk of late mortality. We aimed to explore the risk of late mortality and the pattern of mortality among long-term survivors of childhood or adolescent CNS tumour.

METHODS: We identified 5-year survivors with childhood or adolescent CNS tumour before age 20 years through the Swedish Cancer Registry. Five controls were randomly matched for each patient to generate the reference group. We retrieved information about death via Cause of Death Register. We calculated the absolute excess risk (AER) of death and the... (More)

PURPOSE: A growing number of young patients with central nervous system (CNS) tumour survived for more than five years. However, these long-term survivors might be at risk of multiple late effects thus leading to a higher risk of late mortality. We aimed to explore the risk of late mortality and the pattern of mortality among long-term survivors of childhood or adolescent CNS tumour.

METHODS: We identified 5-year survivors with childhood or adolescent CNS tumour before age 20 years through the Swedish Cancer Registry. Five controls were randomly matched for each patient to generate the reference group. We retrieved information about death via Cause of Death Register. We calculated the absolute excess risk (AER) of death and the hazard ratio (HR) of death using Cox proportional hazard model.

RESULTS: Long-term survivors with CNS tumour suffered a significant higher risk of overall mortality (HR 6.56, 95% CI 5.71-7.53; AER 5.89, 95% CI 5.03-6.87). The mortality rate declined with the increasing survival time, but it was still higher even after 30 years of follow-up. Malignant neoplasms contributed mostly to late mortality with an AER of 3.75 (95% CI 2.95-4.75). Female survivors, survivors diagnosed at a younger age and survivors with medulloblastoma were particularly strongly associated with a higher risk of death.

CONCLUSIONS: Long-term survivors of childhood and adolescent CNS tumours are at a higher risk of late mortality, and the risk of death is affected by gender, age at diagnosis and types of CNS tumour.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Neuro-Oncology
volume
145
issue
3
pages
541 - 549
publisher
Springer
external identifiers
  • pmid:31677032
  • scopus:85074867638
ISSN
1573-7373
DOI
10.1007/s11060-019-03321-w
language
English
LU publication?
yes
id
bc40486f-38fc-4586-85a5-cbfc5159a16b
date added to LUP
2019-11-08 10:06:14
date last changed
2024-08-21 10:51:10
@article{bc40486f-38fc-4586-85a5-cbfc5159a16b,
  abstract     = {{<p>PURPOSE: A growing number of young patients with central nervous system (CNS) tumour survived for more than five years. However, these long-term survivors might be at risk of multiple late effects thus leading to a higher risk of late mortality. We aimed to explore the risk of late mortality and the pattern of mortality among long-term survivors of childhood or adolescent CNS tumour.</p><p>METHODS: We identified 5-year survivors with childhood or adolescent CNS tumour before age 20 years through the Swedish Cancer Registry. Five controls were randomly matched for each patient to generate the reference group. We retrieved information about death via Cause of Death Register. We calculated the absolute excess risk (AER) of death and the hazard ratio (HR) of death using Cox proportional hazard model.</p><p>RESULTS: Long-term survivors with CNS tumour suffered a significant higher risk of overall mortality (HR 6.56, 95% CI 5.71-7.53; AER 5.89, 95% CI 5.03-6.87). The mortality rate declined with the increasing survival time, but it was still higher even after 30 years of follow-up. Malignant neoplasms contributed mostly to late mortality with an AER of 3.75 (95% CI 2.95-4.75). Female survivors, survivors diagnosed at a younger age and survivors with medulloblastoma were particularly strongly associated with a higher risk of death.</p><p>CONCLUSIONS: Long-term survivors of childhood and adolescent CNS tumours are at a higher risk of late mortality, and the risk of death is affected by gender, age at diagnosis and types of CNS tumour.</p>}},
  author       = {{Huang, Wuqing and Sundquist, Jan and Sundquist, Kristina and Ji, Jianguang}},
  issn         = {{1573-7373}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{541--549}},
  publisher    = {{Springer}},
  series       = {{Journal of Neuro-Oncology}},
  title        = {{Mortality patterns in long-term survivors of childhood or adolescent central nervous system tumour in Sweden}},
  url          = {{http://dx.doi.org/10.1007/s11060-019-03321-w}},
  doi          = {{10.1007/s11060-019-03321-w}},
  volume       = {{145}},
  year         = {{2019}},
}