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Intake of Lactiplantibacillus plantarum HEAL9 Improves Cognition in Moderately Stressed Subjects : A Randomized Controlled Study

Önning, Gunilla LU ; Montelius, Caroline LU ; Hillman, Magnus LU and Larsson, Niklas LU (2023) In Nutrients 15(15).
Abstract

Background: The usage of probiotics has expanded beyond the areas of gut and immune health improvement. Several studies have shown the positive impact associated between probiotics and stress, cognition, and mood; a relationship referred to as the gut–brain axis. Method: The aim of this exploratory study was to evaluate the effect of the probiotic strain Lactiplantibacillus plantarum HEAL9 (LPHEAL9) on the gut–brain axis in subjects with moderate stress. One hundred and twenty-nine subjects aged 21–52 years completed the study, randomized to consume either LPHEAL9 (n = 65) or placebo (n = 64) for 12 weeks. Results: Perceived stress and awakening cortisol were significantly reduced over time in both groups. A significant improvement in... (More)

Background: The usage of probiotics has expanded beyond the areas of gut and immune health improvement. Several studies have shown the positive impact associated between probiotics and stress, cognition, and mood; a relationship referred to as the gut–brain axis. Method: The aim of this exploratory study was to evaluate the effect of the probiotic strain Lactiplantibacillus plantarum HEAL9 (LPHEAL9) on the gut–brain axis in subjects with moderate stress. One hundred and twenty-nine subjects aged 21–52 years completed the study, randomized to consume either LPHEAL9 (n = 65) or placebo (n = 64) for 12 weeks. Results: Perceived stress and awakening cortisol were significantly reduced over time in both groups. A significant improvement in four cognition tests after consumption of LPHEAL9 compared to placebo was observed (rapid information processing test, numeric working memory test, paired associated learning, and word recall, p < 0.05). There was a tendency for a significantly better improvement in the LPHEAL9 group for three mood subscales (Confusion–Bewilderment, Anger–Hostility, and Depression–Dejection) and for fewer subjects with poor sleep in the LPHEAL9 group compared to placebo (p < 0.10). Conclusions: Intake of LPHEAL9 significantly improved cognitive functions compared to the placebo, potentially by ameliorating aspects of mood and sleep.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cognition, gut–brain axis, inflammation, L. plantarum, mood, probiotics, sleep, stress, tryptophan, working memory
in
Nutrients
volume
15
issue
15
article number
3466
publisher
MDPI AG
external identifiers
  • pmid:37571403
  • scopus:85167667075
ISSN
2072-6643
DOI
10.3390/nu15153466
language
English
LU publication?
yes
additional info
Funding Information: This work was funded by Probi AB, Lund, Sweden. Publisher Copyright: © 2023 by the authors.
id
bca20e86-9770-4879-a37c-93321268dda9
date added to LUP
2023-08-22 09:47:36
date last changed
2024-04-20 01:11:37
@article{bca20e86-9770-4879-a37c-93321268dda9,
  abstract     = {{<p>Background: The usage of probiotics has expanded beyond the areas of gut and immune health improvement. Several studies have shown the positive impact associated between probiotics and stress, cognition, and mood; a relationship referred to as the gut–brain axis. Method: The aim of this exploratory study was to evaluate the effect of the probiotic strain Lactiplantibacillus plantarum HEAL9 (LPHEAL9) on the gut–brain axis in subjects with moderate stress. One hundred and twenty-nine subjects aged 21–52 years completed the study, randomized to consume either LPHEAL9 (n = 65) or placebo (n = 64) for 12 weeks. Results: Perceived stress and awakening cortisol were significantly reduced over time in both groups. A significant improvement in four cognition tests after consumption of LPHEAL9 compared to placebo was observed (rapid information processing test, numeric working memory test, paired associated learning, and word recall, p &lt; 0.05). There was a tendency for a significantly better improvement in the LPHEAL9 group for three mood subscales (Confusion–Bewilderment, Anger–Hostility, and Depression–Dejection) and for fewer subjects with poor sleep in the LPHEAL9 group compared to placebo (p &lt; 0.10). Conclusions: Intake of LPHEAL9 significantly improved cognitive functions compared to the placebo, potentially by ameliorating aspects of mood and sleep.</p>}},
  author       = {{Önning, Gunilla and Montelius, Caroline and Hillman, Magnus and Larsson, Niklas}},
  issn         = {{2072-6643}},
  keywords     = {{cognition; gut–brain axis; inflammation; L. plantarum; mood; probiotics; sleep; stress; tryptophan; working memory}},
  language     = {{eng}},
  number       = {{15}},
  publisher    = {{MDPI AG}},
  series       = {{Nutrients}},
  title        = {{Intake of Lactiplantibacillus plantarum HEAL9 Improves Cognition in Moderately Stressed Subjects : A Randomized Controlled Study}},
  url          = {{http://dx.doi.org/10.3390/nu15153466}},
  doi          = {{10.3390/nu15153466}},
  volume       = {{15}},
  year         = {{2023}},
}