Comparison of spatially and temporally resolved diffuse-reflectance measurement systems for determination of biomedical optical properties
(2003) In Applied Optics 42(22). p.4612-4620- Abstract
- Time-resolved and spatially resolved measurements of the diffuse reflectance from biological tissue are two well-established techniques for extracting the reduced scattering and absorption coefficients. We have performed a comparison study of the performance of a spatially resolved and a time-resolved instrument at wavelengths 660 and 785 nm and also of an integrating-sphere setup at 550-800 nm. The first system records the diffuse reflectance from a diode laser by means of a fiber bundle probe in contact with the sample. The time-resolved system utilizes picosecond laser pulses and a single-photon-counting detection scheme. We extracted the optical properties by calibration using known standards for the spatially resolved system, by... (More)
- Time-resolved and spatially resolved measurements of the diffuse reflectance from biological tissue are two well-established techniques for extracting the reduced scattering and absorption coefficients. We have performed a comparison study of the performance of a spatially resolved and a time-resolved instrument at wavelengths 660 and 785 nm and also of an integrating-sphere setup at 550-800 nm. The first system records the diffuse reflectance from a diode laser by means of a fiber bundle probe in contact with the sample. The time-resolved system utilizes picosecond laser pulses and a single-photon-counting detection scheme. We extracted the optical properties by calibration using known standards for the spatially resolved system, by fitting to the diffusion equation for the time-resolved system, and by using an inverse Monte Carlo model for the integrating sphere. The measurements were performed on a set of solid epoxy tissue phantoms. The results showed less than 10% difference in the evaluation of the reduced scattering coefficient among the systems for the phantoms in the range 9-20 cm(-1), and absolute differences of less than 0.05 cm(-1) for the absorption coefficient in the interval 0.05-0.30 cm(-1). (C) 2003 Optical Society of America. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/305790
- author
- Swartling, Johannes LU ; Dam, JS and Andersson-Engels, Stefan LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Applied Optics
- volume
- 42
- issue
- 22
- pages
- 4612 - 4620
- publisher
- Optical Society of America
- external identifiers
-
- pmid:12916630
- wos:000184382000028
- scopus:0041880625
- ISSN
- 2155-3165
- language
- English
- LU publication?
- yes
- id
- bde47686-1574-40fa-8fb5-2ba7b35ca280 (old id 305790)
- alternative location
- http://www.opticsinfobase.org/abstract.cfm?URI=ao-42-22-4612
- date added to LUP
- 2016-04-01 11:52:48
- date last changed
- 2022-04-13 02:41:03
@article{bde47686-1574-40fa-8fb5-2ba7b35ca280,
abstract = {{Time-resolved and spatially resolved measurements of the diffuse reflectance from biological tissue are two well-established techniques for extracting the reduced scattering and absorption coefficients. We have performed a comparison study of the performance of a spatially resolved and a time-resolved instrument at wavelengths 660 and 785 nm and also of an integrating-sphere setup at 550-800 nm. The first system records the diffuse reflectance from a diode laser by means of a fiber bundle probe in contact with the sample. The time-resolved system utilizes picosecond laser pulses and a single-photon-counting detection scheme. We extracted the optical properties by calibration using known standards for the spatially resolved system, by fitting to the diffusion equation for the time-resolved system, and by using an inverse Monte Carlo model for the integrating sphere. The measurements were performed on a set of solid epoxy tissue phantoms. The results showed less than 10% difference in the evaluation of the reduced scattering coefficient among the systems for the phantoms in the range 9-20 cm(-1), and absolute differences of less than 0.05 cm(-1) for the absorption coefficient in the interval 0.05-0.30 cm(-1). (C) 2003 Optical Society of America.}},
author = {{Swartling, Johannes and Dam, JS and Andersson-Engels, Stefan}},
issn = {{2155-3165}},
language = {{eng}},
number = {{22}},
pages = {{4612--4620}},
publisher = {{Optical Society of America}},
series = {{Applied Optics}},
title = {{Comparison of spatially and temporally resolved diffuse-reflectance measurement systems for determination of biomedical optical properties}},
url = {{https://lup.lub.lu.se/search/files/2684542/2370817.pdf}},
volume = {{42}},
year = {{2003}},
}