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Brain resting-state connectivity in the development of secondary hyperalgesia in healthy men

Hansen, Morten Sejer ; Becerra, Lino ; Dahl, Jørgen Berg ; Borsook, David ; Mårtensson, Johan LU ; Christensen, Anders ; Nybing, Janus Damm ; Havsteen, Inger ; Boesen, Mikael and Asghar, Mohammad Sohail (2019) In Brain Structure and Function 224(3). p.1119-1139
Abstract

Central sensitization is a condition in which there is an abnormal responsiveness to nociceptive stimuli. As such, the process may contribute to the development and maintenance of pain. Factors influencing the propensity for development of central sensitization have been a subject of intense debate and remain elusive. Injury-induced secondary hyperalgesia can be elicited by experimental pain models in humans, and is believed to be a result of central sensitization. Secondary hyperalgesia may thus reflect the individual level of central sensitization. The objective of this study was to investigate possible associations between increasing size of secondary hyperalgesia area and brain connectivity in known resting-state networks. We... (More)

Central sensitization is a condition in which there is an abnormal responsiveness to nociceptive stimuli. As such, the process may contribute to the development and maintenance of pain. Factors influencing the propensity for development of central sensitization have been a subject of intense debate and remain elusive. Injury-induced secondary hyperalgesia can be elicited by experimental pain models in humans, and is believed to be a result of central sensitization. Secondary hyperalgesia may thus reflect the individual level of central sensitization. The objective of this study was to investigate possible associations between increasing size of secondary hyperalgesia area and brain connectivity in known resting-state networks. We recruited 121 healthy participants (male, age 22, SD 3.35) who underwent resting-state functional magnetic resonance imaging. Prior to the scan session, areas of secondary hyperalgesia following brief thermal sensitization (3 min. 45 °C heat stimulation) were evaluated in all participants. 115 participants were included in the final analysis. We found a positive correlation (increasing connectivity) with increasing area of secondary hyperalgesia in the sensorimotor- and default mode networks. We also observed a negative correlation (decreasing connectivity) with increasing secondary hyperalgesia area in the sensorimotor-, fronto-parietal-, and default mode networks. Our findings indicate that increasing area of secondary hyperalgesia is associated with increasing and decreasing connectivity in multiple networks, suggesting that differences in the propensity for central sensitization, assessed as secondary hyperalgesia areas, may be expressed as differences in the resting-state central neuronal activity.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Central sensitization, MRI, Pain, Resting-state fMRI, Secondary hyperalgesia
in
Brain Structure and Function
volume
224
issue
3
pages
1119 - 1139
publisher
Springer
external identifiers
  • pmid:30631932
  • scopus:85059853528
ISSN
1863-2653
DOI
10.1007/s00429-018-01819-z
language
English
LU publication?
yes
id
be4fef23-f408-4405-bc4e-75f239ce91dd
date added to LUP
2019-01-25 08:29:33
date last changed
2020-01-13 01:23:59
@article{be4fef23-f408-4405-bc4e-75f239ce91dd,
  abstract     = {<p>Central sensitization is a condition in which there is an abnormal responsiveness to nociceptive stimuli. As such, the process may contribute to the development and maintenance of pain. Factors influencing the propensity for development of central sensitization have been a subject of intense debate and remain elusive. Injury-induced secondary hyperalgesia can be elicited by experimental pain models in humans, and is believed to be a result of central sensitization. Secondary hyperalgesia may thus reflect the individual level of central sensitization. The objective of this study was to investigate possible associations between increasing size of secondary hyperalgesia area and brain connectivity in known resting-state networks. We recruited 121 healthy participants (male, age 22, SD 3.35) who underwent resting-state functional magnetic resonance imaging. Prior to the scan session, areas of secondary hyperalgesia following brief thermal sensitization (3 min. 45 °C heat stimulation) were evaluated in all participants. 115 participants were included in the final analysis. We found a positive correlation (increasing connectivity) with increasing area of secondary hyperalgesia in the sensorimotor- and default mode networks. We also observed a negative correlation (decreasing connectivity) with increasing secondary hyperalgesia area in the sensorimotor-, fronto-parietal-, and default mode networks. Our findings indicate that increasing area of secondary hyperalgesia is associated with increasing and decreasing connectivity in multiple networks, suggesting that differences in the propensity for central sensitization, assessed as secondary hyperalgesia areas, may be expressed as differences in the resting-state central neuronal activity.</p>},
  author       = {Hansen, Morten Sejer and Becerra, Lino and Dahl, Jørgen Berg and Borsook, David and Mårtensson, Johan and Christensen, Anders and Nybing, Janus Damm and Havsteen, Inger and Boesen, Mikael and Asghar, Mohammad Sohail},
  issn         = {1863-2653},
  language     = {eng},
  month        = {01},
  number       = {3},
  pages        = {1119--1139},
  publisher    = {Springer},
  series       = {Brain Structure and Function},
  title        = {Brain resting-state connectivity in the development of secondary hyperalgesia in healthy men},
  url          = {http://dx.doi.org/10.1007/s00429-018-01819-z},
  doi          = {10.1007/s00429-018-01819-z},
  volume       = {224},
  year         = {2019},
}