Brain resting-state connectivity in the development of secondary hyperalgesia in healthy men
(2019) In Brain Structure and Function 224(3). p.1119-1139- Abstract
Central sensitization is a condition in which there is an abnormal responsiveness to nociceptive stimuli. As such, the process may contribute to the development and maintenance of pain. Factors influencing the propensity for development of central sensitization have been a subject of intense debate and remain elusive. Injury-induced secondary hyperalgesia can be elicited by experimental pain models in humans, and is believed to be a result of central sensitization. Secondary hyperalgesia may thus reflect the individual level of central sensitization. The objective of this study was to investigate possible associations between increasing size of secondary hyperalgesia area and brain connectivity in known resting-state networks. We... (More)
Central sensitization is a condition in which there is an abnormal responsiveness to nociceptive stimuli. As such, the process may contribute to the development and maintenance of pain. Factors influencing the propensity for development of central sensitization have been a subject of intense debate and remain elusive. Injury-induced secondary hyperalgesia can be elicited by experimental pain models in humans, and is believed to be a result of central sensitization. Secondary hyperalgesia may thus reflect the individual level of central sensitization. The objective of this study was to investigate possible associations between increasing size of secondary hyperalgesia area and brain connectivity in known resting-state networks. We recruited 121 healthy participants (male, age 22, SD 3.35) who underwent resting-state functional magnetic resonance imaging. Prior to the scan session, areas of secondary hyperalgesia following brief thermal sensitization (3 min. 45 °C heat stimulation) were evaluated in all participants. 115 participants were included in the final analysis. We found a positive correlation (increasing connectivity) with increasing area of secondary hyperalgesia in the sensorimotor- and default mode networks. We also observed a negative correlation (decreasing connectivity) with increasing secondary hyperalgesia area in the sensorimotor-, fronto-parietal-, and default mode networks. Our findings indicate that increasing area of secondary hyperalgesia is associated with increasing and decreasing connectivity in multiple networks, suggesting that differences in the propensity for central sensitization, assessed as secondary hyperalgesia areas, may be expressed as differences in the resting-state central neuronal activity.
(Less)
- author
- Hansen, Morten Sejer ; Becerra, Lino ; Dahl, Jørgen Berg ; Borsook, David ; Mårtensson, Johan LU ; Christensen, Anders ; Nybing, Janus Damm ; Havsteen, Inger ; Boesen, Mikael and Asghar, Mohammad Sohail
- organization
- publishing date
- 2019-01-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Central sensitization, MRI, Pain, Resting-state fMRI, Secondary hyperalgesia
- in
- Brain Structure and Function
- volume
- 224
- issue
- 3
- pages
- 1119 - 1139
- publisher
- Springer
- external identifiers
-
- scopus:85059853528
- pmid:30631932
- ISSN
- 1863-2653
- DOI
- 10.1007/s00429-018-01819-z
- language
- English
- LU publication?
- yes
- id
- be4fef23-f408-4405-bc4e-75f239ce91dd
- date added to LUP
- 2019-01-25 08:29:33
- date last changed
- 2024-05-14 00:36:08
@article{be4fef23-f408-4405-bc4e-75f239ce91dd,
abstract = {{<p>Central sensitization is a condition in which there is an abnormal responsiveness to nociceptive stimuli. As such, the process may contribute to the development and maintenance of pain. Factors influencing the propensity for development of central sensitization have been a subject of intense debate and remain elusive. Injury-induced secondary hyperalgesia can be elicited by experimental pain models in humans, and is believed to be a result of central sensitization. Secondary hyperalgesia may thus reflect the individual level of central sensitization. The objective of this study was to investigate possible associations between increasing size of secondary hyperalgesia area and brain connectivity in known resting-state networks. We recruited 121 healthy participants (male, age 22, SD 3.35) who underwent resting-state functional magnetic resonance imaging. Prior to the scan session, areas of secondary hyperalgesia following brief thermal sensitization (3 min. 45 °C heat stimulation) were evaluated in all participants. 115 participants were included in the final analysis. We found a positive correlation (increasing connectivity) with increasing area of secondary hyperalgesia in the sensorimotor- and default mode networks. We also observed a negative correlation (decreasing connectivity) with increasing secondary hyperalgesia area in the sensorimotor-, fronto-parietal-, and default mode networks. Our findings indicate that increasing area of secondary hyperalgesia is associated with increasing and decreasing connectivity in multiple networks, suggesting that differences in the propensity for central sensitization, assessed as secondary hyperalgesia areas, may be expressed as differences in the resting-state central neuronal activity.</p>}},
author = {{Hansen, Morten Sejer and Becerra, Lino and Dahl, Jørgen Berg and Borsook, David and Mårtensson, Johan and Christensen, Anders and Nybing, Janus Damm and Havsteen, Inger and Boesen, Mikael and Asghar, Mohammad Sohail}},
issn = {{1863-2653}},
keywords = {{Central sensitization; MRI; Pain; Resting-state fMRI; Secondary hyperalgesia}},
language = {{eng}},
month = {{01}},
number = {{3}},
pages = {{1119--1139}},
publisher = {{Springer}},
series = {{Brain Structure and Function}},
title = {{Brain resting-state connectivity in the development of secondary hyperalgesia in healthy men}},
url = {{http://dx.doi.org/10.1007/s00429-018-01819-z}},
doi = {{10.1007/s00429-018-01819-z}},
volume = {{224}},
year = {{2019}},
}