Temporal trend of small nerve fibre degeneration in people with and without type 2 diabetes mellitus
(2022) In Diabetic Medicine 39(3).- Abstract
Aims: We investigated the long-term temporal trend of intraepidermal nerve fibre density (IENFD) and the association between changes in IENFD and metabolic factors in individuals with and without type 2 diabetes. Methods: A total of 66 participants were enrolled in this longitudinal population-based study, at baseline consisting of 35 individuals (median 61 years) without diabetes and 31 individuals with type 2 diabetes mellitus. Participants underwent clinical and electrophysiological examinations, as well as a skin biopsy both at baseline and at the follow-up visit (mean 8.1 ± 0.5 years). IENFD was assessed in thin sections of 5 μm, stained with the protein gene product 9.5-antibody and compared between the groups. Results: IENFD... (More)
Aims: We investigated the long-term temporal trend of intraepidermal nerve fibre density (IENFD) and the association between changes in IENFD and metabolic factors in individuals with and without type 2 diabetes. Methods: A total of 66 participants were enrolled in this longitudinal population-based study, at baseline consisting of 35 individuals (median 61 years) without diabetes and 31 individuals with type 2 diabetes mellitus. Participants underwent clinical and electrophysiological examinations, as well as a skin biopsy both at baseline and at the follow-up visit (mean 8.1 ± 0.5 years). IENFD was assessed in thin sections of 5 μm, stained with the protein gene product 9.5-antibody and compared between the groups. Results: IENFD decreased during the period in both groups, with a greater decline in the group without diabetes than in type 2 diabetes (−2.3 and −0.6 fibres/mm respectively; p < 0.001). While IENFD at baseline was significantly reduced in type 2 diabetes relative to people without (p < 0.001), no difference in IENFD was found between groups at the follow-up (p = 0.183). Linear mixed model analysis indicated that age, weight and HbA1c were associated with decrease in IENFD in the total population (p < 0.007). IENFD also decreased with increasing age and weight, but not with HbA1c, in the separate groups (p < 0.049). Conclusions: Despite lower IENFD levels at baseline in type 2 diabetes, IENFD was equal between the groups at follow-up. A decrease in IENFD is to a limited extent affected by body weight, and HbA1c, but age seems to be the long-term determinant of IENFD in an elderly population.
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- author
- Ekman, Linnéa LU ; Pourhamidi, Kaveh ; Englund, Elisabet LU ; Lagali, Neil ; Rolandsson, Olov and Dahlin, Lars B. LU
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- diabetes mellitus, intraepidermal nerve fibre density, longitudinal study, peripheral neuropathy, skin biopsy
- in
- Diabetic Medicine
- volume
- 39
- issue
- 3
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:34536243
- scopus:85115346745
- ISSN
- 0742-3071
- DOI
- 10.1111/dme.14691
- language
- English
- LU publication?
- yes
- id
- be9d8cdc-5c8a-46ae-a549-fb52a0afb32e
- date added to LUP
- 2021-10-04 15:00:57
- date last changed
- 2024-04-06 09:57:29
@article{be9d8cdc-5c8a-46ae-a549-fb52a0afb32e, abstract = {{<p>Aims: We investigated the long-term temporal trend of intraepidermal nerve fibre density (IENFD) and the association between changes in IENFD and metabolic factors in individuals with and without type 2 diabetes. Methods: A total of 66 participants were enrolled in this longitudinal population-based study, at baseline consisting of 35 individuals (median 61 years) without diabetes and 31 individuals with type 2 diabetes mellitus. Participants underwent clinical and electrophysiological examinations, as well as a skin biopsy both at baseline and at the follow-up visit (mean 8.1 ± 0.5 years). IENFD was assessed in thin sections of 5 μm, stained with the protein gene product 9.5-antibody and compared between the groups. Results: IENFD decreased during the period in both groups, with a greater decline in the group without diabetes than in type 2 diabetes (−2.3 and −0.6 fibres/mm respectively; p < 0.001). While IENFD at baseline was significantly reduced in type 2 diabetes relative to people without (p < 0.001), no difference in IENFD was found between groups at the follow-up (p = 0.183). Linear mixed model analysis indicated that age, weight and HbA<sub>1c</sub> were associated with decrease in IENFD in the total population (p < 0.007). IENFD also decreased with increasing age and weight, but not with HbA<sub>1c</sub>, in the separate groups (p < 0.049). Conclusions: Despite lower IENFD levels at baseline in type 2 diabetes, IENFD was equal between the groups at follow-up. A decrease in IENFD is to a limited extent affected by body weight, and HbA<sub>1c</sub>, but age seems to be the long-term determinant of IENFD in an elderly population.</p>}}, author = {{Ekman, Linnéa and Pourhamidi, Kaveh and Englund, Elisabet and Lagali, Neil and Rolandsson, Olov and Dahlin, Lars B.}}, issn = {{0742-3071}}, keywords = {{diabetes mellitus; intraepidermal nerve fibre density; longitudinal study; peripheral neuropathy; skin biopsy}}, language = {{eng}}, number = {{3}}, publisher = {{Wiley-Blackwell}}, series = {{Diabetic Medicine}}, title = {{Temporal trend of small nerve fibre degeneration in people with and without type 2 diabetes mellitus}}, url = {{http://dx.doi.org/10.1111/dme.14691}}, doi = {{10.1111/dme.14691}}, volume = {{39}}, year = {{2022}}, }