Antibodies to pneumococcal polysaccharides in human milk : lack of relationship to colonization and acute otitis media
(1996) In Pediatric Infectious Disease Journal 15(6). p.498-507- Abstract
BACKGROUND: This study analyzed antibodies to pneumococcal polysaccharides in human milk and their effect on nasopharyngeal colonization and acute otitis media in breast-fed infants.
METHODS: A total of 503 milk samples were collected from 310 mothers. Nasopharyngeal cultures were obtained from their children at 2, 6 and 10 months postpartum, and the capsular groups/types of the Streptococcus pneumoniae isolates were determined.
RESULTS: Types 6A, 6B, 19A, 19F and 23F accounted for 54% of the pneumococcal isolates, but type 3 isolates were uncommon. Milk samples were analyzed for antibody activity to the common capsular polysaccharide types 6A, 19F and 23F; to the type 3 polysaccharide; to C-polysaccharide; and to... (More)
BACKGROUND: This study analyzed antibodies to pneumococcal polysaccharides in human milk and their effect on nasopharyngeal colonization and acute otitis media in breast-fed infants.
METHODS: A total of 503 milk samples were collected from 310 mothers. Nasopharyngeal cultures were obtained from their children at 2, 6 and 10 months postpartum, and the capsular groups/types of the Streptococcus pneumoniae isolates were determined.
RESULTS: Types 6A, 6B, 19A, 19F and 23F accounted for 54% of the pneumococcal isolates, but type 3 isolates were uncommon. Milk samples were analyzed for antibody activity to the common capsular polysaccharide types 6A, 19F and 23F; to the type 3 polysaccharide; to C-polysaccharide; and to phosphorylcholine (PC), a major component of the pneumococcal cell wall polysaccharide (CWPS). Anti-capsular antibody activity was low or absent in > 90% of the milk samples. In contrast anti-PC antibody activity was detected in 88% and anti-CWPS in 84% of the samples. The frequency of acute otitis media did not vary with the milk anti-capsular, anti-PC or anti-CWPS antibody activity.
CONCLUSIONS: There was no reduction in nasopharyngeal carriage of S. pneumoniae among children fed milk with anti-capsular or anti-PC antibody activity, but carriage was increased in those children who received milk with anti-CWPS antibody activity. A protective role of antipolysaccharide or anti-CWPS antibodies in milk was not detected under the study conditions.
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- author
- Rosen, I Andersson ; Håkansson, Anders P LU ; Aniansson, G LU ; Hansson, C ; Andersson, B ; Nylén, O ; Sabharwal, H and Svanborg, C LU
- organization
- publishing date
- 1996-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adult, Animals, Antibodies, Bacterial, Bacterial Capsules, Breast Feeding, Female, Humans, Infant, Infant, Newborn, Milk, Nasopharyngeal Diseases, Otitis Media, Phosphorylcholine, Polysaccharides, Bacterial, Streptococcus pneumoniae
- in
- Pediatric Infectious Disease Journal
- volume
- 15
- issue
- 6
- pages
- 498 - 507
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- scopus:0006366581
- pmid:8783346
- ISSN
- 0891-3668
- language
- English
- LU publication?
- yes
- id
- bebec87e-4d47-412c-a575-988a5c3c4742
- date added to LUP
- 2016-05-21 11:33:51
- date last changed
- 2024-07-26 09:59:04
@article{bebec87e-4d47-412c-a575-988a5c3c4742, abstract = {{<p>BACKGROUND: This study analyzed antibodies to pneumococcal polysaccharides in human milk and their effect on nasopharyngeal colonization and acute otitis media in breast-fed infants.</p><p>METHODS: A total of 503 milk samples were collected from 310 mothers. Nasopharyngeal cultures were obtained from their children at 2, 6 and 10 months postpartum, and the capsular groups/types of the Streptococcus pneumoniae isolates were determined.</p><p>RESULTS: Types 6A, 6B, 19A, 19F and 23F accounted for 54% of the pneumococcal isolates, but type 3 isolates were uncommon. Milk samples were analyzed for antibody activity to the common capsular polysaccharide types 6A, 19F and 23F; to the type 3 polysaccharide; to C-polysaccharide; and to phosphorylcholine (PC), a major component of the pneumococcal cell wall polysaccharide (CWPS). Anti-capsular antibody activity was low or absent in > 90% of the milk samples. In contrast anti-PC antibody activity was detected in 88% and anti-CWPS in 84% of the samples. The frequency of acute otitis media did not vary with the milk anti-capsular, anti-PC or anti-CWPS antibody activity.</p><p>CONCLUSIONS: There was no reduction in nasopharyngeal carriage of S. pneumoniae among children fed milk with anti-capsular or anti-PC antibody activity, but carriage was increased in those children who received milk with anti-CWPS antibody activity. A protective role of antipolysaccharide or anti-CWPS antibodies in milk was not detected under the study conditions.</p>}}, author = {{Rosen, I Andersson and Håkansson, Anders P and Aniansson, G and Hansson, C and Andersson, B and Nylén, O and Sabharwal, H and Svanborg, C}}, issn = {{0891-3668}}, keywords = {{Adult; Animals; Antibodies, Bacterial; Bacterial Capsules; Breast Feeding; Female; Humans; Infant; Infant, Newborn; Milk; Nasopharyngeal Diseases; Otitis Media; Phosphorylcholine; Polysaccharides, Bacterial; Streptococcus pneumoniae}}, language = {{eng}}, number = {{6}}, pages = {{498--507}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Pediatric Infectious Disease Journal}}, title = {{Antibodies to pneumococcal polysaccharides in human milk : lack of relationship to colonization and acute otitis media}}, volume = {{15}}, year = {{1996}}, }