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Familial Risks of Glaucoma in the Population of Sweden

Li, Xinjun LU ; Sundquist, Jan LU ; Zöller, Bengt LU and Sundquist, Kristina LU (2018) In Journal of Glaucoma
Abstract

Background: Glaucoma has a familial component but detailed data on the modification of familial risks are lacking. The aim of the study was to determine detailed familial risks for medically diagnosed glaucoma based on nationwide hospital and population records. Methods: Subjects were obtained from the Multigeneration Register, contains the Swedish population in families, and glaucoma patients were identified from the Hospital Discharge Register (1987-2012) and the Outpatient Register (2001-2012). Standardized incidence ratios (SIRs) were calculated as the ratio of observed to expected number of cases. Results: Familial risks were increased in both males and females. Concordant familial risks were generally higher than discordant risks.... (More)

Background: Glaucoma has a familial component but detailed data on the modification of familial risks are lacking. The aim of the study was to determine detailed familial risks for medically diagnosed glaucoma based on nationwide hospital and population records. Methods: Subjects were obtained from the Multigeneration Register, contains the Swedish population in families, and glaucoma patients were identified from the Hospital Discharge Register (1987-2012) and the Outpatient Register (2001-2012). Standardized incidence ratios (SIRs) were calculated as the ratio of observed to expected number of cases. Results: Familial risks were increased in both males and females. Concordant familial risks were generally higher than discordant risks. For example, familial concordant risks were SIR=3.25 (95% CI, 3.16-3.35) for primary open-angle glaucoma, 9.93 (95% CI, 7.30-13.22) for primary angle-closure glaucoma. Very high familial risks were observed if two or more relatives were affected, for example, the high risk group of multiple affected siblings with an SIR >20. The spouse risk was modestly increased 1.20. Conclusions and Relevance:: Family history of glaucoma is a strong predictor for glaucoma, and is a potential useful tool in clinical risk assessment. Our data emphasize the contribution of familial factors to the glaucoma.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
affected family members, glaucoma, heritability
in
Journal of Glaucoma
publisher
Raven Press
external identifiers
  • scopus:85049154242
ISSN
1057-0829
DOI
10.1097/IJG.0000000000001013
language
English
LU publication?
yes
id
bed2a1d9-7437-4024-a1a9-68e74aba2801
date added to LUP
2018-07-13 15:14:31
date last changed
2018-11-21 21:40:44
@article{bed2a1d9-7437-4024-a1a9-68e74aba2801,
  abstract     = {<p>Background: Glaucoma has a familial component but detailed data on the modification of familial risks are lacking. The aim of the study was to determine detailed familial risks for medically diagnosed glaucoma based on nationwide hospital and population records. Methods: Subjects were obtained from the Multigeneration Register, contains the Swedish population in families, and glaucoma patients were identified from the Hospital Discharge Register (1987-2012) and the Outpatient Register (2001-2012). Standardized incidence ratios (SIRs) were calculated as the ratio of observed to expected number of cases. Results: Familial risks were increased in both males and females. Concordant familial risks were generally higher than discordant risks. For example, familial concordant risks were SIR=3.25 (95% CI, 3.16-3.35) for primary open-angle glaucoma, 9.93 (95% CI, 7.30-13.22) for primary angle-closure glaucoma. Very high familial risks were observed if two or more relatives were affected, for example, the high risk group of multiple affected siblings with an SIR &gt;20. The spouse risk was modestly increased 1.20. Conclusions and Relevance:: Family history of glaucoma is a strong predictor for glaucoma, and is a potential useful tool in clinical risk assessment. Our data emphasize the contribution of familial factors to the glaucoma.</p>},
  author       = {Li, Xinjun and Sundquist, Jan and Zöller, Bengt and Sundquist, Kristina},
  issn         = {1057-0829},
  keyword      = {affected family members,glaucoma,heritability},
  language     = {eng},
  month        = {06},
  publisher    = {Raven Press},
  series       = {Journal of Glaucoma},
  title        = {Familial Risks of Glaucoma in the Population of Sweden},
  url          = {http://dx.doi.org/10.1097/IJG.0000000000001013},
  year         = {2018},
}