Albuminuria and hypertension are independently associated with circulating antipericyte autoantibodies in type 2 diabetic patients
(2005) In Metabolism, Clinical and Experimental 54(2). p.188-193- Abstract
- Aims: To determine whether albuminuria, hypertension, or HbA(1c) are independently associated with antipericyte autoantibodies (APAAs) in type 2 diabetes mellitus. Methods: Two hundred ninety-nine subjects with different degrees of retinopathy according to the Early Treatment Diabetic Retinopathy Study Scale participated in this study. Albuminuria was defined as an albumin/creatinine ratio above the normal cutoff limit, that is, 2.0 g/mol for men and 2.8 g/mol for women. Hypertension was defined as a diastolic blood pressure more than 90 mm Hg, a systolic blood pressure more than 140 mm Hg, or pharmacological antihypertensive treatment. Serum APAAs were detected by immunofluorescence on tissue-cultured bovine retinal pericytes. Association... (More)
- Aims: To determine whether albuminuria, hypertension, or HbA(1c) are independently associated with antipericyte autoantibodies (APAAs) in type 2 diabetes mellitus. Methods: Two hundred ninety-nine subjects with different degrees of retinopathy according to the Early Treatment Diabetic Retinopathy Study Scale participated in this study. Albuminuria was defined as an albumin/creatinine ratio above the normal cutoff limit, that is, 2.0 g/mol for men and 2.8 g/mol for women. Hypertension was defined as a diastolic blood pressure more than 90 mm Hg, a systolic blood pressure more than 140 mm Hg, or pharmacological antihypertensive treatment. Serum APAAs were detected by immunofluorescence on tissue-cultured bovine retinal pericytes. Association analysis was performed using univariate and multivariate statistical tools. Results: In type 2 diabetes, APAAs were independently associated with albuminuria (OR = 0.56; P < .04), hypertension (OR = 2.21; P < .01), as well as with proliferative retinopathy (OR = 0.39; P < .01). Conclusions: The increased prevalence of APAA in patients with hypertension may suggest that these antibodies are related to tissue damage and repair and that the decline in frequency with albuminuria may serve as a marker for more advanced angiopathy. Future longitudinal studies are needed to determine whether the frequency of APAA is associated with the progression of angiopathy, and to determine the biological activity and antigens recognized by the antibody. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/897387
- author
- Nayak, RC ; Agardh, Elisabet LU ; Kwok, MGK ; Farthing-Nayak, PJ ; Lynch, Kristian LU and Agardh, Carl-David LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Metabolism, Clinical and Experimental
- volume
- 54
- issue
- 2
- pages
- 188 - 193
- publisher
- Elsevier
- external identifiers
-
- wos:000227141500008
- pmid:15690312
- scopus:12944325308
- ISSN
- 1532-8600
- DOI
- 10.1016/j.metabol.2004.08.011
- language
- English
- LU publication?
- yes
- id
- bf110b9a-5ca6-44ba-bed4-b699a5823bd2 (old id 897387)
- date added to LUP
- 2016-04-01 16:49:03
- date last changed
- 2022-01-28 22:23:09
@article{bf110b9a-5ca6-44ba-bed4-b699a5823bd2, abstract = {{Aims: To determine whether albuminuria, hypertension, or HbA(1c) are independently associated with antipericyte autoantibodies (APAAs) in type 2 diabetes mellitus. Methods: Two hundred ninety-nine subjects with different degrees of retinopathy according to the Early Treatment Diabetic Retinopathy Study Scale participated in this study. Albuminuria was defined as an albumin/creatinine ratio above the normal cutoff limit, that is, 2.0 g/mol for men and 2.8 g/mol for women. Hypertension was defined as a diastolic blood pressure more than 90 mm Hg, a systolic blood pressure more than 140 mm Hg, or pharmacological antihypertensive treatment. Serum APAAs were detected by immunofluorescence on tissue-cultured bovine retinal pericytes. Association analysis was performed using univariate and multivariate statistical tools. Results: In type 2 diabetes, APAAs were independently associated with albuminuria (OR = 0.56; P < .04), hypertension (OR = 2.21; P < .01), as well as with proliferative retinopathy (OR = 0.39; P < .01). Conclusions: The increased prevalence of APAA in patients with hypertension may suggest that these antibodies are related to tissue damage and repair and that the decline in frequency with albuminuria may serve as a marker for more advanced angiopathy. Future longitudinal studies are needed to determine whether the frequency of APAA is associated with the progression of angiopathy, and to determine the biological activity and antigens recognized by the antibody.}}, author = {{Nayak, RC and Agardh, Elisabet and Kwok, MGK and Farthing-Nayak, PJ and Lynch, Kristian and Agardh, Carl-David}}, issn = {{1532-8600}}, language = {{eng}}, number = {{2}}, pages = {{188--193}}, publisher = {{Elsevier}}, series = {{Metabolism, Clinical and Experimental}}, title = {{Albuminuria and hypertension are independently associated with circulating antipericyte autoantibodies in type 2 diabetic patients}}, url = {{http://dx.doi.org/10.1016/j.metabol.2004.08.011}}, doi = {{10.1016/j.metabol.2004.08.011}}, volume = {{54}}, year = {{2005}}, }