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Pre-vaccination seroprevalence of 15 human papillomavirus (HPV) types among women in the population-based Slovenian cervical screening program

Ucakar, Veronika; Jelen, Mateja M.; Faust, Helena LU ; Poljak, Mario; Dillner, Joakim LU and Klavs, Irena (2013) In Vaccine 31(43). p.4935-4939
Abstract
Objectives: To estimate seroprevalence of 11 high-risk (hr) HPV types and four low-risk (lr) HPV types among 20-64 years old Slovenian women participating in the population-based cervical cancer screening program. Methods: Serum samples from 3259 women were tested for HPV type-specific antibodies with a multiplexed pseudovirion-based serological assay (PsV-Luminex). Results: Seropositivity for any of the 15 HPV types was 65.7%, any of the 11 hr-HPV types 59.2%, and any of the four lr-HPV types 33.1%. Antibodies against at least one of the four vaccine HPV types (HPV 6, 11, 16, 18) were detected in 40.8% women. Among hr-HPV types, seropositivity was highest for HPV 16 (25.2%) and among lr-HPV types for HPV 6(19.1%). Age-specific HPV16... (More)
Objectives: To estimate seroprevalence of 11 high-risk (hr) HPV types and four low-risk (lr) HPV types among 20-64 years old Slovenian women participating in the population-based cervical cancer screening program. Methods: Serum samples from 3259 women were tested for HPV type-specific antibodies with a multiplexed pseudovirion-based serological assay (PsV-Luminex). Results: Seropositivity for any of the 15 HPV types was 65.7%, any of the 11 hr-HPV types 59.2%, and any of the four lr-HPV types 33.1%. Antibodies against at least one of the four vaccine HPV types (HPV 6, 11, 16, 18) were detected in 40.8% women. Among hr-HPV types, seropositivity was highest for HPV 16 (25.2%) and among lr-HPV types for HPV 6(19.1%). Age-specific HPV16 seropositivity was highest among 30-39 years old (29.6%) and decreased with increasing age to 14.0% among 60-64 years old. Conclusion: The lifetime sexual exposure to genital HPV types is substantial, emphasising the need for HPV vaccination. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
HPV, Seroprevalence, Cross-sectional study, Slovenia
in
Vaccine
volume
31
issue
43
pages
4935 - 4939
publisher
Elsevier
external identifiers
  • wos:000326255400002
  • scopus:84885125081
ISSN
1873-2518
DOI
10.1016/j.vaccine.2013.08.038
language
English
LU publication?
yes
id
bf37f42b-3cc2-42b9-9215-580698c0dca7 (old id 4212864)
date added to LUP
2014-01-03 10:48:55
date last changed
2019-01-06 04:20:52
@article{bf37f42b-3cc2-42b9-9215-580698c0dca7,
  abstract     = {Objectives: To estimate seroprevalence of 11 high-risk (hr) HPV types and four low-risk (lr) HPV types among 20-64 years old Slovenian women participating in the population-based cervical cancer screening program. Methods: Serum samples from 3259 women were tested for HPV type-specific antibodies with a multiplexed pseudovirion-based serological assay (PsV-Luminex). Results: Seropositivity for any of the 15 HPV types was 65.7%, any of the 11 hr-HPV types 59.2%, and any of the four lr-HPV types 33.1%. Antibodies against at least one of the four vaccine HPV types (HPV 6, 11, 16, 18) were detected in 40.8% women. Among hr-HPV types, seropositivity was highest for HPV 16 (25.2%) and among lr-HPV types for HPV 6(19.1%). Age-specific HPV16 seropositivity was highest among 30-39 years old (29.6%) and decreased with increasing age to 14.0% among 60-64 years old. Conclusion: The lifetime sexual exposure to genital HPV types is substantial, emphasising the need for HPV vaccination. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.},
  author       = {Ucakar, Veronika and Jelen, Mateja M. and Faust, Helena and Poljak, Mario and Dillner, Joakim and Klavs, Irena},
  issn         = {1873-2518},
  keyword      = {HPV,Seroprevalence,Cross-sectional study,Slovenia},
  language     = {eng},
  number       = {43},
  pages        = {4935--4939},
  publisher    = {Elsevier},
  series       = {Vaccine},
  title        = {Pre-vaccination seroprevalence of 15 human papillomavirus (HPV) types among women in the population-based Slovenian cervical screening program},
  url          = {http://dx.doi.org/10.1016/j.vaccine.2013.08.038},
  volume       = {31},
  year         = {2013},
}