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Pre-vaccination seroprevalence of 15 human papillomavirus (HPV) types among women in the population-based Slovenian cervical screening program

Ucakar, Veronika ; Jelen, Mateja M. ; Faust, Helena LU ; Poljak, Mario ; Dillner, Joakim LU and Klavs, Irena (2013) In Vaccine 31(43). p.4935-4939
Abstract
Objectives: To estimate seroprevalence of 11 high-risk (hr) HPV types and four low-risk (lr) HPV types among 20-64 years old Slovenian women participating in the population-based cervical cancer screening program. Methods: Serum samples from 3259 women were tested for HPV type-specific antibodies with a multiplexed pseudovirion-based serological assay (PsV-Luminex). Results: Seropositivity for any of the 15 HPV types was 65.7%, any of the 11 hr-HPV types 59.2%, and any of the four lr-HPV types 33.1%. Antibodies against at least one of the four vaccine HPV types (HPV 6, 11, 16, 18) were detected in 40.8% women. Among hr-HPV types, seropositivity was highest for HPV 16 (25.2%) and among lr-HPV types for HPV 6(19.1%). Age-specific HPV16... (More)
Objectives: To estimate seroprevalence of 11 high-risk (hr) HPV types and four low-risk (lr) HPV types among 20-64 years old Slovenian women participating in the population-based cervical cancer screening program. Methods: Serum samples from 3259 women were tested for HPV type-specific antibodies with a multiplexed pseudovirion-based serological assay (PsV-Luminex). Results: Seropositivity for any of the 15 HPV types was 65.7%, any of the 11 hr-HPV types 59.2%, and any of the four lr-HPV types 33.1%. Antibodies against at least one of the four vaccine HPV types (HPV 6, 11, 16, 18) were detected in 40.8% women. Among hr-HPV types, seropositivity was highest for HPV 16 (25.2%) and among lr-HPV types for HPV 6(19.1%). Age-specific HPV16 seropositivity was highest among 30-39 years old (29.6%) and decreased with increasing age to 14.0% among 60-64 years old. Conclusion: The lifetime sexual exposure to genital HPV types is substantial, emphasising the need for HPV vaccination. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
HPV, Seroprevalence, Cross-sectional study, Slovenia
in
Vaccine
volume
31
issue
43
pages
4935 - 4939
publisher
Elsevier
external identifiers
  • wos:000326255400002
  • scopus:84885125081
  • pmid:23994822
ISSN
1873-2518
DOI
10.1016/j.vaccine.2013.08.038
language
English
LU publication?
yes
id
bf37f42b-3cc2-42b9-9215-580698c0dca7 (old id 4212864)
date added to LUP
2016-04-01 10:32:46
date last changed
2022-04-04 19:09:34
@article{bf37f42b-3cc2-42b9-9215-580698c0dca7,
  abstract     = {{Objectives: To estimate seroprevalence of 11 high-risk (hr) HPV types and four low-risk (lr) HPV types among 20-64 years old Slovenian women participating in the population-based cervical cancer screening program. Methods: Serum samples from 3259 women were tested for HPV type-specific antibodies with a multiplexed pseudovirion-based serological assay (PsV-Luminex). Results: Seropositivity for any of the 15 HPV types was 65.7%, any of the 11 hr-HPV types 59.2%, and any of the four lr-HPV types 33.1%. Antibodies against at least one of the four vaccine HPV types (HPV 6, 11, 16, 18) were detected in 40.8% women. Among hr-HPV types, seropositivity was highest for HPV 16 (25.2%) and among lr-HPV types for HPV 6(19.1%). Age-specific HPV16 seropositivity was highest among 30-39 years old (29.6%) and decreased with increasing age to 14.0% among 60-64 years old. Conclusion: The lifetime sexual exposure to genital HPV types is substantial, emphasising the need for HPV vaccination. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.}},
  author       = {{Ucakar, Veronika and Jelen, Mateja M. and Faust, Helena and Poljak, Mario and Dillner, Joakim and Klavs, Irena}},
  issn         = {{1873-2518}},
  keywords     = {{HPV; Seroprevalence; Cross-sectional study; Slovenia}},
  language     = {{eng}},
  number       = {{43}},
  pages        = {{4935--4939}},
  publisher    = {{Elsevier}},
  series       = {{Vaccine}},
  title        = {{Pre-vaccination seroprevalence of 15 human papillomavirus (HPV) types among women in the population-based Slovenian cervical screening program}},
  url          = {{http://dx.doi.org/10.1016/j.vaccine.2013.08.038}},
  doi          = {{10.1016/j.vaccine.2013.08.038}},
  volume       = {{31}},
  year         = {{2013}},
}