Molecular mechanisms of Streptococcus dysgalactiae subsp equisimilis enabling intravascular persistence
(2012) In Microbes and Infection 14(4). p.329-334- Abstract
- Streptococcus dysgalactiae subsp. equisimilis (SDSE) can cause recurrent bacteremic infection. We have characterized novel virulence properties of an SDSE isolate of type stG485.0 that caused severe sepsis three times in a patient despite that he had opsonizing antibodies to the isolate. An infected aortic aneurysm was suspected to be the focus for the persisting bacteria. For the first time we show that this SDSE isolate, as well as other invasive SDSE isolates, aggregate human platelets and efficiently internalize into human endothelial cells. These properties may aid SDSE to persist and could explain the tendency of SDSE to cause recurrent bacteremia. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2587772
- author
- Rohde, Manfred ; Talay, Susanne R. and Rasmussen, Magnus LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Recurrent bacteremia, Intravascular persistence, Internalization, Platelet aggregation
- in
- Microbes and Infection
- volume
- 14
- issue
- 4
- pages
- 329 - 334
- publisher
- Elsevier
- external identifiers
-
- wos:000302428300005
- scopus:84857994314
- pmid:22100875
- ISSN
- 1769-714X
- DOI
- 10.1016/j.micinf.2011.10.008
- language
- English
- LU publication?
- yes
- id
- bf8038b4-7fb0-4bff-a1c1-d4fbdc553b6c (old id 2587772)
- date added to LUP
- 2016-04-01 10:26:37
- date last changed
- 2022-04-27 22:08:34
@article{bf8038b4-7fb0-4bff-a1c1-d4fbdc553b6c, abstract = {{Streptococcus dysgalactiae subsp. equisimilis (SDSE) can cause recurrent bacteremic infection. We have characterized novel virulence properties of an SDSE isolate of type stG485.0 that caused severe sepsis three times in a patient despite that he had opsonizing antibodies to the isolate. An infected aortic aneurysm was suspected to be the focus for the persisting bacteria. For the first time we show that this SDSE isolate, as well as other invasive SDSE isolates, aggregate human platelets and efficiently internalize into human endothelial cells. These properties may aid SDSE to persist and could explain the tendency of SDSE to cause recurrent bacteremia. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.}}, author = {{Rohde, Manfred and Talay, Susanne R. and Rasmussen, Magnus}}, issn = {{1769-714X}}, keywords = {{Recurrent bacteremia; Intravascular persistence; Internalization; Platelet aggregation}}, language = {{eng}}, number = {{4}}, pages = {{329--334}}, publisher = {{Elsevier}}, series = {{Microbes and Infection}}, title = {{Molecular mechanisms of Streptococcus dysgalactiae subsp equisimilis enabling intravascular persistence}}, url = {{http://dx.doi.org/10.1016/j.micinf.2011.10.008}}, doi = {{10.1016/j.micinf.2011.10.008}}, volume = {{14}}, year = {{2012}}, }