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Translational opportunities of single-cell biology in atherosclerosis

De Winther, Menno P.J. ; Bäck, Magnus ; Evans, Paul ; Gomez, Delphine ; Goncalves, Isabel LU orcid ; Jørgensen, Helle F. ; Koenen, Rory R. ; Lutgens, Esther ; Norata, Giuseppe Danilo and Osto, Elena , et al. (2023) In European Heart Journal 44(14). p.1216-1230
Abstract

The advent of single-cell biology opens a new chapter for understanding human biological processes and for diagnosing, monitoring, and treating disease. This revolution now reaches the field of cardiovascular disease (CVD). New technologies to interrogate CVD samples at single-cell resolution are allowing the identification of novel cell communities that are important in shaping disease development and direct towards new therapeutic strategies. These approaches have begun to revolutionize atherosclerosis pathology and redraw our understanding of disease development. This review discusses the state-of-the-art of single-cell analysis of atherosclerotic plaques, with a particular focus on human lesions, and presents the current resolution... (More)

The advent of single-cell biology opens a new chapter for understanding human biological processes and for diagnosing, monitoring, and treating disease. This revolution now reaches the field of cardiovascular disease (CVD). New technologies to interrogate CVD samples at single-cell resolution are allowing the identification of novel cell communities that are important in shaping disease development and direct towards new therapeutic strategies. These approaches have begun to revolutionize atherosclerosis pathology and redraw our understanding of disease development. This review discusses the state-of-the-art of single-cell analysis of atherosclerotic plaques, with a particular focus on human lesions, and presents the current resolution of cellular subpopulations and their heterogeneity and plasticity in relation to clinically relevant features. Opportunities and pitfalls of current technologies as well as the clinical impact of single-cell technologies in CVD patient care are highlighted, advocating for multidisciplinary and international collaborative efforts to join the cellular dots of CVD.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Atherosclerosis, Endothelial cell, Lymphocyte, Macrophage, Single-cell biology, Smooth muscle cell
in
European Heart Journal
volume
44
issue
14
pages
15 pages
publisher
Oxford University Press
external identifiers
  • pmid:36478058
  • scopus:85152164399
ISSN
0195-668X
DOI
10.1093/eurheartj/ehac686
language
English
LU publication?
yes
id
bf980cbe-73d3-42c8-8d1b-d7740963c191
date added to LUP
2023-08-04 16:40:12
date last changed
2024-04-20 01:07:31
@article{bf980cbe-73d3-42c8-8d1b-d7740963c191,
  abstract     = {{<p>The advent of single-cell biology opens a new chapter for understanding human biological processes and for diagnosing, monitoring, and treating disease. This revolution now reaches the field of cardiovascular disease (CVD). New technologies to interrogate CVD samples at single-cell resolution are allowing the identification of novel cell communities that are important in shaping disease development and direct towards new therapeutic strategies. These approaches have begun to revolutionize atherosclerosis pathology and redraw our understanding of disease development. This review discusses the state-of-the-art of single-cell analysis of atherosclerotic plaques, with a particular focus on human lesions, and presents the current resolution of cellular subpopulations and their heterogeneity and plasticity in relation to clinically relevant features. Opportunities and pitfalls of current technologies as well as the clinical impact of single-cell technologies in CVD patient care are highlighted, advocating for multidisciplinary and international collaborative efforts to join the cellular dots of CVD.</p>}},
  author       = {{De Winther, Menno P.J. and Bäck, Magnus and Evans, Paul and Gomez, Delphine and Goncalves, Isabel and Jørgensen, Helle F. and Koenen, Rory R. and Lutgens, Esther and Norata, Giuseppe Danilo and Osto, Elena and Dib, Lea and Simons, Michael and Stellos, Konstantinos and Ylä-Herttuala, Seppo and Winkels, Holger and Bochaton-Piallat, Marie Luce and Monaco, Claudia}},
  issn         = {{0195-668X}},
  keywords     = {{Atherosclerosis; Endothelial cell; Lymphocyte; Macrophage; Single-cell biology; Smooth muscle cell}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{14}},
  pages        = {{1216--1230}},
  publisher    = {{Oxford University Press}},
  series       = {{European Heart Journal}},
  title        = {{Translational opportunities of single-cell biology in atherosclerosis}},
  url          = {{http://dx.doi.org/10.1093/eurheartj/ehac686}},
  doi          = {{10.1093/eurheartj/ehac686}},
  volume       = {{44}},
  year         = {{2023}},
}