Personalised nutrition : status and perspectives
(2007) In British Journal of Nutrition 98(01). p.26-31- Abstract
- Personalised, genotype-based nutrition is a concept that links genotyping with specific nutritional advice in order to improve the prevention of nutrition-associated, chronic diseases. This review describes the current scientific basis of the concept and discusses its problems. There is convincing evidence that variant genes may indeed determine the biological response to nutrients. The effects of single-gene variants on risk or risk factor levels of a complex disease are, however, usually small and sometimes inconsistent. Thus, information on the effects of combinations of relevant gene variants appears to be required in order to improve the predictive precision of the genetic information. Furthermore, very few associations between... (More)
- Personalised, genotype-based nutrition is a concept that links genotyping with specific nutritional advice in order to improve the prevention of nutrition-associated, chronic diseases. This review describes the current scientific basis of the concept and discusses its problems. There is convincing evidence that variant genes may indeed determine the biological response to nutrients. The effects of single-gene variants on risk or risk factor levels of a complex disease are, however, usually small and sometimes inconsistent. Thus, information on the effects of combinations of relevant gene variants appears to be required in order to improve the predictive precision of the genetic information. Furthermore, very few associations between genotype and response have been tested for causality in human intervention studies, and little is known about potential adverse effects of a genotype-derived intervention. These issues need to be addressed before genotyping can become an acceptable method to guide nutritional recommendations. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/541239
- author
- Joost, Hans-Georg ; Gibney, Michael J. ; Cashman, Kevin D. ; Görman, Ulf LU ; Hesketh, John E. ; Mueller, Michael ; van Ommen, Ben ; Williams, Christine M. and Mathers, John C.
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- disease risk, genotype, nutrigenetics, nutritional recommendations, nutrigenomics
- in
- British Journal of Nutrition
- volume
- 98
- issue
- 01
- pages
- 26 - 31
- publisher
- Cambridge University Press
- external identifiers
-
- wos:000248305100004
- scopus:34547989732
- ISSN
- 1475-2662
- DOI
- 10.1017/S0007114507685195
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Centre for Theology and Religious Studies (015017000)
- id
- bfa18647-ae26-4834-80d4-5a710f684a5e (old id 541239)
- date added to LUP
- 2016-04-01 11:56:15
- date last changed
- 2022-02-18 07:30:28
@article{bfa18647-ae26-4834-80d4-5a710f684a5e,
abstract = {{Personalised, genotype-based nutrition is a concept that links genotyping with specific nutritional advice in order to improve the prevention of nutrition-associated, chronic diseases. This review describes the current scientific basis of the concept and discusses its problems. There is convincing evidence that variant genes may indeed determine the biological response to nutrients. The effects of single-gene variants on risk or risk factor levels of a complex disease are, however, usually small and sometimes inconsistent. Thus, information on the effects of combinations of relevant gene variants appears to be required in order to improve the predictive precision of the genetic information. Furthermore, very few associations between genotype and response have been tested for causality in human intervention studies, and little is known about potential adverse effects of a genotype-derived intervention. These issues need to be addressed before genotyping can become an acceptable method to guide nutritional recommendations.}},
author = {{Joost, Hans-Georg and Gibney, Michael J. and Cashman, Kevin D. and Görman, Ulf and Hesketh, John E. and Mueller, Michael and van Ommen, Ben and Williams, Christine M. and Mathers, John C.}},
issn = {{1475-2662}},
keywords = {{disease risk; genotype; nutrigenetics; nutritional recommendations; nutrigenomics}},
language = {{eng}},
number = {{01}},
pages = {{26--31}},
publisher = {{Cambridge University Press}},
series = {{British Journal of Nutrition}},
title = {{Personalised nutrition : status and perspectives}},
url = {{http://dx.doi.org/10.1017/S0007114507685195}},
doi = {{10.1017/S0007114507685195}},
volume = {{98}},
year = {{2007}},
}