Advanced

A post hoc analysis of Dupuytren contracture treated with collagenase Clostridium histolyticum across disease stages

Pess, Gary M.; Sundbom, Maj; Wilson, Koo; Lindqvist, Daniel and Dahlin, Lars B. LU (2018) In Journal of Plastic Surgery and Hand Surgery2010-01-01+01:00 52(5). p.301-306
Abstract

This post hoc analysis from a multicenter study (NCT01674634) was designed to evaluate the efficacy of collagenase Clostridium histolyticum (CCH) treatment in patients with different stages of Dupuytren contracture. Previously untreated patients who received two concurrent injections of CCH in two affected joints in the same finger were assessed by disease severity (Tubiana stage). The mean (SD) improvement in total fixed flexion contraction (FFC) 31 days post-CCH treatment in 181 patients was: 71.1 (36.5)% for Tubiana I, 77.0 (21.0)% for Tubiana II, 72.0 (20.4)% for Tubiana III and 66.4 (22.2)% for Tubiana IV. Treatment of metacarpophalangeal and proximal interphalangeal joints in the same finger resulted in a mean (SD) improvement of... (More)

This post hoc analysis from a multicenter study (NCT01674634) was designed to evaluate the efficacy of collagenase Clostridium histolyticum (CCH) treatment in patients with different stages of Dupuytren contracture. Previously untreated patients who received two concurrent injections of CCH in two affected joints in the same finger were assessed by disease severity (Tubiana stage). The mean (SD) improvement in total fixed flexion contraction (FFC) 31 days post-CCH treatment in 181 patients was: 71.1 (36.5)% for Tubiana I, 77.0 (21.0)% for Tubiana II, 72.0 (20.4)% for Tubiana III and 66.4 (22.2)% for Tubiana IV. Treatment of metacarpophalangeal and proximal interphalangeal joints in the same finger resulted in a mean (SD) improvement of 82.5 (24.8)% and 66.4 (27.9)%, respectively. In conclusion, CCH is an effective treatment alternative for all stages of Dupuytren contracture and it provides a less invasive treatment alternative to surgery with similar short-term efficacy in patients with more severe disease.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Collagenase Clostridium histolyticum, Dupuytren contracture, fasciectomy, fixed flexion contracture, percutaneous needle fasciotomy
in
Journal of Plastic Surgery and Hand Surgery2010-01-01+01:00
volume
52
issue
5
pages
301 - 306
publisher
Taylor & Francis
external identifiers
  • scopus:85050553457
ISSN
2000-656X
DOI
10.1080/2000656X.2018.1484753
language
English
LU publication?
yes
id
bfb85f35-3907-4d1e-b84c-dac6201bbb67
date added to LUP
2018-09-26 13:52:17
date last changed
2019-02-20 11:27:42
@article{bfb85f35-3907-4d1e-b84c-dac6201bbb67,
  abstract     = {<p>This post hoc analysis from a multicenter study (NCT01674634) was designed to evaluate the efficacy of collagenase Clostridium histolyticum (CCH) treatment in patients with different stages of Dupuytren contracture. Previously untreated patients who received two concurrent injections of CCH in two affected joints in the same finger were assessed by disease severity (Tubiana stage). The mean (SD) improvement in total fixed flexion contraction (FFC) 31 days post-CCH treatment in 181 patients was: 71.1 (36.5)% for Tubiana I, 77.0 (21.0)% for Tubiana II, 72.0 (20.4)% for Tubiana III and 66.4 (22.2)% for Tubiana IV. Treatment of metacarpophalangeal and proximal interphalangeal joints in the same finger resulted in a mean (SD) improvement of 82.5 (24.8)% and 66.4 (27.9)%, respectively. In conclusion, CCH is an effective treatment alternative for all stages of Dupuytren contracture and it provides a less invasive treatment alternative to surgery with similar short-term efficacy in patients with more severe disease.</p>},
  author       = {Pess, Gary M. and Sundbom, Maj and Wilson, Koo and Lindqvist, Daniel and Dahlin, Lars B.},
  issn         = {2000-656X},
  keyword      = {Collagenase Clostridium histolyticum,Dupuytren contracture,fasciectomy,fixed flexion contracture,percutaneous needle fasciotomy},
  language     = {eng},
  month        = {07},
  number       = {5},
  pages        = {301--306},
  publisher    = {Taylor & Francis},
  series       = {Journal of Plastic Surgery and Hand Surgery2010-01-01+01:00},
  title        = {A post hoc analysis of Dupuytren contracture treated with collagenase Clostridium histolyticum across disease stages},
  url          = {http://dx.doi.org/10.1080/2000656X.2018.1484753},
  volume       = {52},
  year         = {2018},
}