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Risks for familial and contralateral breast cancer interact multiplicatively and cause a high risk

Hemminki, Kari LU ; Ji, Jianguang LU and Försti, Asta LU (2007) In Cancer Research 67(3). p.70-868
Abstract

The reasons for the high risk of contralateral breast cancer are not understood, although polygenic mechanisms have been suggested to be involved. The nationwide Swedish Family-Cancer Database was used to examine the interaction of the risks for contralateral and familial cancer. Relative risks were separately determined for contralateral and familial breast cancers, and these were tested for additive and multiplicative interactions. The Database contained information on 102,176 first breast cancers. Familial risk for breast cancer was 1.76 and the risk for contralateral breast cancer was 3.40, or 5.80 when extrapolated to two breasts. When women had a family history, the risk for contralateral breast cancer was remarkably high, 5.48,... (More)

The reasons for the high risk of contralateral breast cancer are not understood, although polygenic mechanisms have been suggested to be involved. The nationwide Swedish Family-Cancer Database was used to examine the interaction of the risks for contralateral and familial cancer. Relative risks were separately determined for contralateral and familial breast cancers, and these were tested for additive and multiplicative interactions. The Database contained information on 102,176 first breast cancers. Familial risk for breast cancer was 1.76 and the risk for contralateral breast cancer was 3.40, or 5.80 when extrapolated to two breasts. When women had a family history, the risk for contralateral breast cancer was remarkably high, 5.48, or 9.96 when the risk was extrapolated to two breasts, almost identical with 10.21, which was predicted by the multiplicative model. Although the data do not rule out polygenic mechanisms, they suggest that epigenetic imprinting events may be involved for the contralateral breast cancer.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Breast Neoplasms/epidemiology, Family Health, Female, Genetic Predisposition to Disease, Humans, Neoplasms, Second Primary/epidemiology, Risk Factors, Sweden/epidemiology
in
Cancer Research
volume
67
issue
3
pages
3 pages
publisher
American Association for Cancer Research Inc.
external identifiers
  • scopus:33847054432
ISSN
0008-5472
DOI
10.1158/0008-5472.CAN-06-3854
language
English
LU publication?
no
id
bfea52b7-ee85-4e7d-8d84-f8e0ed00f2c9
date added to LUP
2019-01-30 10:51:27
date last changed
2019-03-27 04:38:15
@article{bfea52b7-ee85-4e7d-8d84-f8e0ed00f2c9,
  abstract     = {<p>The reasons for the high risk of contralateral breast cancer are not understood, although polygenic mechanisms have been suggested to be involved. The nationwide Swedish Family-Cancer Database was used to examine the interaction of the risks for contralateral and familial cancer. Relative risks were separately determined for contralateral and familial breast cancers, and these were tested for additive and multiplicative interactions. The Database contained information on 102,176 first breast cancers. Familial risk for breast cancer was 1.76 and the risk for contralateral breast cancer was 3.40, or 5.80 when extrapolated to two breasts. When women had a family history, the risk for contralateral breast cancer was remarkably high, 5.48, or 9.96 when the risk was extrapolated to two breasts, almost identical with 10.21, which was predicted by the multiplicative model. Although the data do not rule out polygenic mechanisms, they suggest that epigenetic imprinting events may be involved for the contralateral breast cancer.</p>},
  author       = {Hemminki, Kari and Ji, Jianguang and Försti, Asta},
  issn         = {0008-5472},
  keyword      = {Breast Neoplasms/epidemiology,Family Health,Female,Genetic Predisposition to Disease,Humans,Neoplasms, Second Primary/epidemiology,Risk Factors,Sweden/epidemiology},
  language     = {eng},
  month        = {02},
  number       = {3},
  pages        = {70--868},
  publisher    = {American Association for Cancer Research Inc.},
  series       = {Cancer Research},
  title        = {Risks for familial and contralateral breast cancer interact multiplicatively and cause a high risk},
  url          = {http://dx.doi.org/10.1158/0008-5472.CAN-06-3854},
  volume       = {67},
  year         = {2007},
}