Non-reversible heat-induced gelation of a biocompatible Fmoc-hexapeptide in water
(2020) In Nanoscale 12(15). p.8262-8267- Abstract
Hydrogel materials which respond to changes in temperature are widely applicable for injectable drug delivery or tissue engineering applications. Here, we report the unsual heat-induced gelation behaviour of a low molecular weight gelator based on an Fmoc-hexapeptide, Fmoc-GFFRGD. We show that Fmoc-GFFRGD forms kinetically stable fibres when mixed with divalent cations (e.g. Ca2+). Gelation of the mixture occurs upon heating of the mixture which enables electrostatic screening by the divalent cations and hydrophobic collapse of the fibres to give a self-supporting hydrogel network that shows good biocompatibility with L929 fibroblast cells. This work highlights a unique mechanism to initiate heat-induced gelation which should... (More)
Hydrogel materials which respond to changes in temperature are widely applicable for injectable drug delivery or tissue engineering applications. Here, we report the unsual heat-induced gelation behaviour of a low molecular weight gelator based on an Fmoc-hexapeptide, Fmoc-GFFRGD. We show that Fmoc-GFFRGD forms kinetically stable fibres when mixed with divalent cations (e.g. Ca2+). Gelation of the mixture occurs upon heating of the mixture which enables electrostatic screening by the divalent cations and hydrophobic collapse of the fibres to give a self-supporting hydrogel network that shows good biocompatibility with L929 fibroblast cells. This work highlights a unique mechanism to initiate heat-induced gelation which should find opportunities as a gelation trigger for injectable hydrogels or fundamental self-assembly applications.
(Less)
- author
- Wojciechowski, Jonathan P. ; Martin, Adam D. ; Du, Eric Y. ; Garvey, Christopher J. LU ; Nordon, Robert E. and Thordarson, Pall
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nanoscale
- volume
- 12
- issue
- 15
- pages
- 6 pages
- publisher
- Royal Society of Chemistry
- external identifiers
-
- scopus:85083623585
- pmid:32236222
- ISSN
- 2040-3364
- DOI
- 10.1039/d0nr00289e
- language
- English
- LU publication?
- yes
- id
- bffa1f49-4a13-4a3a-b2cd-bbf75d4761f8
- date added to LUP
- 2020-05-20 08:53:49
- date last changed
- 2024-08-21 20:51:48
@article{bffa1f49-4a13-4a3a-b2cd-bbf75d4761f8, abstract = {{<p>Hydrogel materials which respond to changes in temperature are widely applicable for injectable drug delivery or tissue engineering applications. Here, we report the unsual heat-induced gelation behaviour of a low molecular weight gelator based on an Fmoc-hexapeptide, Fmoc-GFFRGD. We show that Fmoc-GFFRGD forms kinetically stable fibres when mixed with divalent cations (e.g. Ca<sup>2+</sup>). Gelation of the mixture occurs upon heating of the mixture which enables electrostatic screening by the divalent cations and hydrophobic collapse of the fibres to give a self-supporting hydrogel network that shows good biocompatibility with L929 fibroblast cells. This work highlights a unique mechanism to initiate heat-induced gelation which should find opportunities as a gelation trigger for injectable hydrogels or fundamental self-assembly applications.</p>}}, author = {{Wojciechowski, Jonathan P. and Martin, Adam D. and Du, Eric Y. and Garvey, Christopher J. and Nordon, Robert E. and Thordarson, Pall}}, issn = {{2040-3364}}, language = {{eng}}, number = {{15}}, pages = {{8262--8267}}, publisher = {{Royal Society of Chemistry}}, series = {{Nanoscale}}, title = {{Non-reversible heat-induced gelation of a biocompatible Fmoc-hexapeptide in water}}, url = {{http://dx.doi.org/10.1039/d0nr00289e}}, doi = {{10.1039/d0nr00289e}}, volume = {{12}}, year = {{2020}}, }