Lymphocyte subpopulations and lymphokine production in children with constitutional aplastic anemia
(1988) In Pediatric Hematology & Oncology 5(2). p.143-151- Abstract
- The expression of lymphocyte surface markers as well as the production of interleukin-2 (IL-2) and interferon-gamma (IFN) by mitogen-stimulated peripheral blood mononuclear cells (MNC) have been studied in five children with constitutional aplastic anemia. A significantly reduced T4/T8 ratio was found and two of five patients also had a reduced percentage of B cells. One patient had a high percentage of HLA-DR positive T8+ cells, very suggestive of a high degree of circulating activated T suppressor/cytotoxic cells. IL-2 production was reduced in two patients, whereas IFN production was only reduced in one of these. The abnormalities found correlate with the duration of the bone marrow failure. The patients with the longest duration of... (More)
- The expression of lymphocyte surface markers as well as the production of interleukin-2 (IL-2) and interferon-gamma (IFN) by mitogen-stimulated peripheral blood mononuclear cells (MNC) have been studied in five children with constitutional aplastic anemia. A significantly reduced T4/T8 ratio was found and two of five patients also had a reduced percentage of B cells. One patient had a high percentage of HLA-DR positive T8+ cells, very suggestive of a high degree of circulating activated T suppressor/cytotoxic cells. IL-2 production was reduced in two patients, whereas IFN production was only reduced in one of these. The abnormalities found correlate with the duration of the bone marrow failure. The patients with the longest duration of bone marrow failure also exhibited the lowest T4/T8 ratio. No spontaneous IFN production was detected in any of the patients. There was no clinical benefit or reversal of the immune abnormalities during and following treatment with cimetidine and cyclosporine A in two patients. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1104094
- author
- Dohlsten, M ; Hedlund, G ; Békássy, Albert LU ; Lindén, Ola LU ; Garwicz, Stanislaw LU ; Wiebe, Thomas LU ; Sjögren, H O and Carlsson, R
- organization
- publishing date
- 1988
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pediatric Hematology & Oncology
- volume
- 5
- issue
- 2
- pages
- 143 - 151
- publisher
- Hemisphere Pub. Corp.
- external identifiers
-
- pmid:2484652
- scopus:0023885565
- ISSN
- 1521-0669
- DOI
- 10.3109/08880018809031264
- language
- English
- LU publication?
- yes
- id
- c00818be-8f78-4971-9802-918c8f78adff (old id 1104094)
- date added to LUP
- 2016-04-01 11:41:27
- date last changed
- 2021-01-03 11:03:36
@article{c00818be-8f78-4971-9802-918c8f78adff, abstract = {{The expression of lymphocyte surface markers as well as the production of interleukin-2 (IL-2) and interferon-gamma (IFN) by mitogen-stimulated peripheral blood mononuclear cells (MNC) have been studied in five children with constitutional aplastic anemia. A significantly reduced T4/T8 ratio was found and two of five patients also had a reduced percentage of B cells. One patient had a high percentage of HLA-DR positive T8+ cells, very suggestive of a high degree of circulating activated T suppressor/cytotoxic cells. IL-2 production was reduced in two patients, whereas IFN production was only reduced in one of these. The abnormalities found correlate with the duration of the bone marrow failure. The patients with the longest duration of bone marrow failure also exhibited the lowest T4/T8 ratio. No spontaneous IFN production was detected in any of the patients. There was no clinical benefit or reversal of the immune abnormalities during and following treatment with cimetidine and cyclosporine A in two patients.}}, author = {{Dohlsten, M and Hedlund, G and Békássy, Albert and Lindén, Ola and Garwicz, Stanislaw and Wiebe, Thomas and Sjögren, H O and Carlsson, R}}, issn = {{1521-0669}}, language = {{eng}}, number = {{2}}, pages = {{143--151}}, publisher = {{Hemisphere Pub. Corp.}}, series = {{Pediatric Hematology & Oncology}}, title = {{Lymphocyte subpopulations and lymphokine production in children with constitutional aplastic anemia}}, url = {{http://dx.doi.org/10.3109/08880018809031264}}, doi = {{10.3109/08880018809031264}}, volume = {{5}}, year = {{1988}}, }