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Chemical Properties of Cartilage Studied Using Charged Ions

Söderman, Olle LU ; Algotsson, Jenny LU ; Dahlberg, Leif E. LU and Svensson, Jonas LU (2017) In Biophysics and Biochemistry of Cartilage by NMR and MRI 2017-January(8). p.176-190
Abstract

Articular cartilage is a soft tissue built mainly from collagen and highly negatively charged biological polyelectrolytes. The high negative charge is responsible for crucial properties of cartilage, such as tissue hydration and biomechanical load resistance. As a consequence, breakdown and loss of the polyelectrolytes in cartilage has an adverse effect on its function and there is a need for methods to determine the amount of polyelectrolytes in cartilage. Here we discuss one such method, the delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). dGEMRIC builds on the fact that a negatively charged MRI contrast agent will distribute in an inverse relation to the concentration of polyelectrolytes on account of the electrostatic... (More)

Articular cartilage is a soft tissue built mainly from collagen and highly negatively charged biological polyelectrolytes. The high negative charge is responsible for crucial properties of cartilage, such as tissue hydration and biomechanical load resistance. As a consequence, breakdown and loss of the polyelectrolytes in cartilage has an adverse effect on its function and there is a need for methods to determine the amount of polyelectrolytes in cartilage. Here we discuss one such method, the delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). dGEMRIC builds on the fact that a negatively charged MRI contrast agent will distribute in an inverse relation to the concentration of polyelectrolytes on account of the electrostatic repulsion between the two. We introduce the method and discuss some of the key assumptions. In particular, we focus on the relaxivity parameter that should be used to convert the measured water spin-lattice relaxation times to a concentration of the contrast agent, the time for reaching equilibrium with respect to penetration of the contrast agent into cartilage and the use of ideal Donnan equilibrium in the further analysis of dGEMRIC data. Finally, we present some examples of clinical applications of the dGEMRIC method.

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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
in
Biophysics and Biochemistry of Cartilage by NMR and MRI
editor
Xia, Y.; Momot, K.; and
volume
2017-January
issue
8
pages
15 pages
publisher
Royal Society of Chemistry
external identifiers
  • scopus:85006341309
ISSN
2044253X
20442548
ISBN
978-1-78262-133-1
978-1-78262-905-4
DOI
10.1039/9781782623663-00176
language
English
LU publication?
yes
id
c0478504-4d75-44d3-8dba-0b20205b9869
date added to LUP
2017-01-13 13:40:01
date last changed
2018-01-07 11:45:05
@inbook{c0478504-4d75-44d3-8dba-0b20205b9869,
  abstract     = {<p>Articular cartilage is a soft tissue built mainly from collagen and highly negatively charged biological polyelectrolytes. The high negative charge is responsible for crucial properties of cartilage, such as tissue hydration and biomechanical load resistance. As a consequence, breakdown and loss of the polyelectrolytes in cartilage has an adverse effect on its function and there is a need for methods to determine the amount of polyelectrolytes in cartilage. Here we discuss one such method, the delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). dGEMRIC builds on the fact that a negatively charged MRI contrast agent will distribute in an inverse relation to the concentration of polyelectrolytes on account of the electrostatic repulsion between the two. We introduce the method and discuss some of the key assumptions. In particular, we focus on the relaxivity parameter that should be used to convert the measured water spin-lattice relaxation times to a concentration of the contrast agent, the time for reaching equilibrium with respect to penetration of the contrast agent into cartilage and the use of ideal Donnan equilibrium in the further analysis of dGEMRIC data. Finally, we present some examples of clinical applications of the dGEMRIC method.</p>},
  author       = {Söderman, Olle and Algotsson, Jenny and Dahlberg, Leif E. and Svensson, Jonas},
  editor       = {Xia, Y. and Momot, K.},
  isbn         = { 978-1-78262-133-1},
  issn         = {2044253X},
  language     = {eng},
  number       = {8},
  pages        = {176--190},
  publisher    = {Royal Society of Chemistry},
  series       = {Biophysics and Biochemistry of Cartilage by NMR and MRI},
  title        = {Chemical Properties of Cartilage Studied Using Charged Ions},
  url          = {http://dx.doi.org/10.1039/9781782623663-00176},
  volume       = {2017-January},
  year         = {2017},
}