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A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study

Marjonen, Heidi ; Marttila, Minttu ; Paajanen, Teemu ; Vornanen, Marleena ; Brunfeldt, Minna ; Joensuu, Anni ; Halmesvaara, Otto ; Aro, Kimmo ; Alanne-Kinnunen, Mervi and Jousilahti, Pekka , et al. (2021) In Frontiers in Genetics 12.
Abstract

We present a method for communicating personalized genetic risk information to citizens and their physicians using a secure web portal. We apply the method for 3,177 Finnish individuals in the P5 Study where estimates of genetic and absolute risk, based on genetic and clinical risk factors, of future disease are reported to study participants, allowing individuals to participate in managing their own health. Our method facilitates using polygenic risk score as a personalized tool to estimate a person’s future disease risk while offering a way for health care professionals to utilize the polygenic risk scores as a preventive tool in patient care.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
coronary heart disease, finhealth 2017 study, P5 study, polygenic risk sore, precision population health, type 2 diabetes, venous thromboembolism, web portal
in
Frontiers in Genetics
volume
12
article number
763159
publisher
Frontiers Media S. A.
external identifiers
  • pmid:34777479
  • scopus:85119034268
ISSN
1664-8021
DOI
10.3389/fgene.2021.763159
language
English
LU publication?
yes
additional info
Publisher Copyright: Copyright © 2021 Marjonen, Marttila, Paajanen, Vornanen, Brunfeldt, Joensuu, Halmesvaara, Aro, Alanne-Kinnunen, Jousilahti, Borodulin, Koskinen, Tuomi, Ilanne-Parikka, Lindström, Laine, Auro, Kääriäinen, Perola and Kristiansson.
id
c05944a1-12c2-42db-81fb-0b4b38fb7ab5
date added to LUP
2022-01-21 16:57:52
date last changed
2024-06-16 00:12:27
@article{c05944a1-12c2-42db-81fb-0b4b38fb7ab5,
  abstract     = {{<p>We present a method for communicating personalized genetic risk information to citizens and their physicians using a secure web portal. We apply the method for 3,177 Finnish individuals in the P5 Study where estimates of genetic and absolute risk, based on genetic and clinical risk factors, of future disease are reported to study participants, allowing individuals to participate in managing their own health. Our method facilitates using polygenic risk score as a personalized tool to estimate a person’s future disease risk while offering a way for health care professionals to utilize the polygenic risk scores as a preventive tool in patient care.</p>}},
  author       = {{Marjonen, Heidi and Marttila, Minttu and Paajanen, Teemu and Vornanen, Marleena and Brunfeldt, Minna and Joensuu, Anni and Halmesvaara, Otto and Aro, Kimmo and Alanne-Kinnunen, Mervi and Jousilahti, Pekka and Borodulin, Katja and Koskinen, Seppo and Tuomi, Tiinamaija and Ilanne-Parikka, Pirjo and Lindström, Jaana and Laine, Merja K. and Auro, Kirsi and Kääriäinen, Helena and Perola, Markus and Kristiansson, Kati}},
  issn         = {{1664-8021}},
  keywords     = {{coronary heart disease; finhealth 2017 study; P5 study; polygenic risk sore; precision population health; type 2 diabetes; venous thromboembolism; web portal}},
  language     = {{eng}},
  month        = {{10}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Genetics}},
  title        = {{A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study}},
  url          = {{http://dx.doi.org/10.3389/fgene.2021.763159}},
  doi          = {{10.3389/fgene.2021.763159}},
  volume       = {{12}},
  year         = {{2021}},
}