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Impact of Exercise on Hemophilia

Zetterberg, Eva LU ; Ljungkvist, Marcus LU and Salim, Maryem LU (2018) In Seminars in Thrombosis and Hemostasis 44(8). p.787-795
Abstract

Sports and strenuous exercise have traditionally been discouraged for people with hemophilia (PWH) because of the perceived risk of bleeding. In this review, studies investigating the pros and cons of exercise are presented, and although most studies are of low validity, the randomized trials that do exist tell us that PWH benefit from exercise in terms of improved muscular function, endurance, and quality of life and that increased bleeding does not seem to be an issue. The authors also review the studies that have analyzed the current physical status of PWH compared with the general population in different countries. Finally, they review the current knowledge on the effect of exercise on specific coagulation factors as well as on... (More)

Sports and strenuous exercise have traditionally been discouraged for people with hemophilia (PWH) because of the perceived risk of bleeding. In this review, studies investigating the pros and cons of exercise are presented, and although most studies are of low validity, the randomized trials that do exist tell us that PWH benefit from exercise in terms of improved muscular function, endurance, and quality of life and that increased bleeding does not seem to be an issue. The authors also review the studies that have analyzed the current physical status of PWH compared with the general population in different countries. Finally, they review the current knowledge on the effect of exercise on specific coagulation factors as well as on global coagulation and demonstrate that exercise increases factor VIII levels in healthy persons, all persons with hemophilia B (HB) and in persons with mild and moderate hemophilia A (HA). Further, the authors did not find any evidence that the global coagulation capacity, measured with thrombin generation or thromboelastographic methods, increases after exercise in severe HA or HB.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Seminars in Thrombosis and Hemostasis
volume
44
issue
8
pages
9 pages
publisher
Georg Thieme Verlag KG
external identifiers
  • scopus:85055907082
  • pmid:30357762
ISSN
1098-9064
DOI
10.1055/s-0038-1675381
language
English
LU publication?
yes
id
c070ef68-244f-4330-a7a4-a8722c6a41c4
date added to LUP
2018-11-14 13:01:46
date last changed
2021-09-22 02:01:29
@article{c070ef68-244f-4330-a7a4-a8722c6a41c4,
  abstract     = {<p>Sports and strenuous exercise have traditionally been discouraged for people with hemophilia (PWH) because of the perceived risk of bleeding. In this review, studies investigating the pros and cons of exercise are presented, and although most studies are of low validity, the randomized trials that do exist tell us that PWH benefit from exercise in terms of improved muscular function, endurance, and quality of life and that increased bleeding does not seem to be an issue. The authors also review the studies that have analyzed the current physical status of PWH compared with the general population in different countries. Finally, they review the current knowledge on the effect of exercise on specific coagulation factors as well as on global coagulation and demonstrate that exercise increases factor VIII levels in healthy persons, all persons with hemophilia B (HB) and in persons with mild and moderate hemophilia A (HA). Further, the authors did not find any evidence that the global coagulation capacity, measured with thrombin generation or thromboelastographic methods, increases after exercise in severe HA or HB.</p>},
  author       = {Zetterberg, Eva and Ljungkvist, Marcus and Salim, Maryem},
  issn         = {1098-9064},
  language     = {eng},
  number       = {8},
  pages        = {787--795},
  publisher    = {Georg Thieme Verlag KG},
  series       = {Seminars in Thrombosis and Hemostasis},
  title        = {Impact of Exercise on Hemophilia},
  url          = {http://dx.doi.org/10.1055/s-0038-1675381},
  doi          = {10.1055/s-0038-1675381},
  volume       = {44},
  year         = {2018},
}