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Photoallergic contact dermatitis from ketoprofen induced by drug-contaminated personal objects

Hindsén, Monica LU ; Isaksson, Marléne LU ; Persson, L ; Zimersson, E and Bruze, Magnus LU (2004) In Journal of American Academy of Dermatology 50(2). p.215-219
Abstract
Background: Photoallergic contact dermatitis from ketoprofen has been recognized since the mid-1980s. Skin reactions have been reported to continue weeks after discontinuation of ketoprofen. One reason for this could be residual ketoprofen in the skin, which has been shown in a skin biopsy specimen. Objective: We sought to report on 3 cases of photoallergic contact dermatitis from ketoprofen in topical anti-inflammatory gels and on relapses of dermatitis appearing after use of ketoprofen-contaminated objects. Methods: We patch and photopatch tested, with standard series, the anti-inflammatory gel, ketoprofen, and its ingredients in serial dilutions and extracts of personal objects. We performed chemical investigations of personal objects... (More)
Background: Photoallergic contact dermatitis from ketoprofen has been recognized since the mid-1980s. Skin reactions have been reported to continue weeks after discontinuation of ketoprofen. One reason for this could be residual ketoprofen in the skin, which has been shown in a skin biopsy specimen. Objective: We sought to report on 3 cases of photoallergic contact dermatitis from ketoprofen in topical anti-inflammatory gels and on relapses of dermatitis appearing after use of ketoprofen-contaminated objects. Methods: We patch and photopatch tested, with standard series, the anti-inflammatory gel, ketoprofen, and its ingredients in serial dilutions and extracts of personal objects. We performed chemical investigations of personal objects with thin-layer chromatography, high-pressure liquid chromatography, and gas chromatography-mass spectrometry. Results: Photoallergy was demonstrated to ketoprofen, which was detected in personal objects. Conclusion: Relapses of photoallergic contact dermatitis in patients photoallergic to ketoprofen can be induced by ketoprofen-contaminated objects such as bandages and slippers. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of American Academy of Dermatology
volume
50
issue
2
pages
215 - 219
publisher
Elsevier
external identifiers
  • wos:000188710100007
  • scopus:0842310851
ISSN
0190-9622
DOI
10.1016/j.jaad.2003.07.007
language
English
LU publication?
yes
id
c0b2c840-1960-452c-9111-1869f88857b5 (old id 899404)
date added to LUP
2016-04-01 12:10:46
date last changed
2022-02-03 18:39:32
@article{c0b2c840-1960-452c-9111-1869f88857b5,
  abstract     = {{Background: Photoallergic contact dermatitis from ketoprofen has been recognized since the mid-1980s. Skin reactions have been reported to continue weeks after discontinuation of ketoprofen. One reason for this could be residual ketoprofen in the skin, which has been shown in a skin biopsy specimen. Objective: We sought to report on 3 cases of photoallergic contact dermatitis from ketoprofen in topical anti-inflammatory gels and on relapses of dermatitis appearing after use of ketoprofen-contaminated objects. Methods: We patch and photopatch tested, with standard series, the anti-inflammatory gel, ketoprofen, and its ingredients in serial dilutions and extracts of personal objects. We performed chemical investigations of personal objects with thin-layer chromatography, high-pressure liquid chromatography, and gas chromatography-mass spectrometry. Results: Photoallergy was demonstrated to ketoprofen, which was detected in personal objects. Conclusion: Relapses of photoallergic contact dermatitis in patients photoallergic to ketoprofen can be induced by ketoprofen-contaminated objects such as bandages and slippers.}},
  author       = {{Hindsén, Monica and Isaksson, Marléne and Persson, L and Zimersson, E and Bruze, Magnus}},
  issn         = {{0190-9622}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{215--219}},
  publisher    = {{Elsevier}},
  series       = {{Journal of American Academy of Dermatology}},
  title        = {{Photoallergic contact dermatitis from ketoprofen induced by drug-contaminated personal objects}},
  url          = {{http://dx.doi.org/10.1016/j.jaad.2003.07.007}},
  doi          = {{10.1016/j.jaad.2003.07.007}},
  volume       = {{50}},
  year         = {{2004}},
}