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Photoacoustic imaging for the monitoring of local changes in oxygen saturation following an adrenaline injection in human forearm skin

Bunke, Josefine LU ; Merdasa, Aboma LU ; Sheikh, Rafi LU orcid ; Albinsson, John LU ; Erlöv, Tobias LU ; Gesslein, Bodil LU ; Cinthio, Magnus LU ; Reistad, Nina LU orcid and Malmsjö, Malin LU (2021) In Biomedical Optics Express 12(7). p.4084-4096
Abstract
Clinical monitoring of blood oxygen saturation (sO2) is traditionally performed using optical techniques, such as pulse oximetry and diffuse reflectance spectroscopy (DRS), which lack spatial resolution. Photoacoustic imaging (PAI) is a rapidly developing biomedical imaging technique that is superior to previous techniques in that it combines optical excitation and acoustic detection, providing a map of chromophore distribution in the tissue. Hitherto, PAI has primarily been used in preclinical studies, and only a few studies have been performed in patients. Its ability to measure sO2 with spatial resolution during local vasoconstriction after adrenaline injection has not yet been investigated. Using PAI and spectral unmixing we... (More)
Clinical monitoring of blood oxygen saturation (sO2) is traditionally performed using optical techniques, such as pulse oximetry and diffuse reflectance spectroscopy (DRS), which lack spatial resolution. Photoacoustic imaging (PAI) is a rapidly developing biomedical imaging technique that is superior to previous techniques in that it combines optical excitation and acoustic detection, providing a map of chromophore distribution in the tissue. Hitherto, PAI has primarily been used in preclinical studies, and only a few studies have been performed in patients. Its ability to measure sO2 with spatial resolution during local vasoconstriction after adrenaline injection has not yet been investigated. Using PAI and spectral unmixing we characterize the heterogeneous change in sO2 after injecting a local anesthetic containing adrenaline into the dermis on the forearm of seven healthy subjects. In comparison to results obtained using DRS, we highlight contrasting results obtained between the two methods arising due to the so-called ‘window effect’ caused by a reduced blood flow in the superficial vascular plexus. The results demonstrate the importance of spatially resolving sO2 and the ability of PAI to assess the tissue composition in different layers of the skin. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Diffuse optical tomography, Diffuse reflectance spectroscopy, Imaging techniques, Magnetic resonance imaging, Medical imaging, Speckle imaging
in
Biomedical Optics Express
volume
12
issue
7
pages
13 pages
publisher
Optical Society of America
external identifiers
  • scopus:85108266875
  • pmid:34457400
ISSN
2156-7085
DOI
10.1364/BOE.423876
language
English
LU publication?
yes
additional info
Funding Information: Funding. Swedish Government Grant for Clinical Research (ALF); Skånes universitetssjukhus; Region Kronoberg; Skåne County Council’s Research and Development Foundation; Lund University Grant for Research Infrastructure; Swedish Cancer Foundation; Stiftelsen Kronprinsessan Margaretas Arbetsnämnd för Synskadade; Friends of the Visually Impaired Association in the county of Gävleborg (KMA); Lund Laser Center Research Grant; IngaBritt och Arne Lundbergs Forskningsstiftelse; Ögonfonden; Cronqvist Foundation; Swedish Medical Association; Lund University grant for Research Infrastructure; Stiftelsen för Synskadade i f.d. Malmöhus län. Publisher Copyright: © 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
id
c0cbe669-fd08-4bca-9fdf-eb4b8255a3cc
date added to LUP
2021-06-15 17:17:25
date last changed
2022-04-28 11:16:08
@article{c0cbe669-fd08-4bca-9fdf-eb4b8255a3cc,
  abstract     = {{Clinical monitoring of blood oxygen saturation (sO2) is traditionally performed using optical techniques, such as pulse oximetry and diffuse reflectance spectroscopy (DRS), which lack spatial resolution. Photoacoustic imaging (PAI) is a rapidly developing biomedical imaging technique that is superior to previous techniques in that it combines optical excitation and acoustic detection, providing a map of chromophore distribution in the tissue. Hitherto, PAI has primarily been used in preclinical studies, and only a few studies have been performed in patients. Its ability to measure sO2 with spatial resolution during local vasoconstriction after adrenaline injection has not yet been investigated. Using PAI and spectral unmixing we characterize the heterogeneous change in sO2 after injecting a local anesthetic containing adrenaline into the dermis on the forearm of seven healthy subjects. In comparison to results obtained using DRS, we highlight contrasting results obtained between the two methods arising due to the so-called ‘window effect’ caused by a reduced blood flow in the superficial vascular plexus. The results demonstrate the importance of spatially resolving sO2 and the ability of PAI to assess the tissue composition in different layers of the skin.}},
  author       = {{Bunke, Josefine and Merdasa, Aboma and Sheikh, Rafi and Albinsson, John and Erlöv, Tobias and Gesslein, Bodil and Cinthio, Magnus and Reistad, Nina and Malmsjö, Malin}},
  issn         = {{2156-7085}},
  keywords     = {{Diffuse optical tomography; Diffuse reflectance spectroscopy; Imaging techniques; Magnetic resonance imaging; Medical imaging; Speckle imaging}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{7}},
  pages        = {{4084--4096}},
  publisher    = {{Optical Society of America}},
  series       = {{Biomedical Optics Express}},
  title        = {{Photoacoustic imaging for the monitoring of local changes in oxygen saturation following an adrenaline injection in human forearm skin}},
  url          = {{http://dx.doi.org/10.1364/BOE.423876}},
  doi          = {{10.1364/BOE.423876}},
  volume       = {{12}},
  year         = {{2021}},
}