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Fully automated joint space width measurement and digital X-ray radiogrammetry in early RA

Platten, Michael; Kisten, Yogan; Kälvesten, Johan; Arnaud, Laurent; Forslind, Kristina LU and van Vollenhoven, Ronald (2017) In RMD Open 3(1).
Abstract

Objectives To study fully automated digital joint space width (JSW) and bone mineral density (BMD) in relation to a conventional radiographic scoring method in early rheumatoid arthritis (eRA). Methods Radiographs scored by the modified Sharp van der Heijde score (SHS) in patients with eRA were acquired from the SWEdish FarmacOTherapy study. Fully automated JSW measurements of bilateral metacarpals 2, 3 and 4 were compared with the joint space narrowing (JSN) score in SHS. Multilevel mixed model statistics were applied to calculate the significance of the association between ΔJSW and ΔBMD over 1 year, and the JSW differences between damaged and undamaged joints as evaluated by the JSN. Results Based on 576 joints of 96 patients with... (More)

Objectives To study fully automated digital joint space width (JSW) and bone mineral density (BMD) in relation to a conventional radiographic scoring method in early rheumatoid arthritis (eRA). Methods Radiographs scored by the modified Sharp van der Heijde score (SHS) in patients with eRA were acquired from the SWEdish FarmacOTherapy study. Fully automated JSW measurements of bilateral metacarpals 2, 3 and 4 were compared with the joint space narrowing (JSN) score in SHS. Multilevel mixed model statistics were applied to calculate the significance of the association between ΔJSW and ΔBMD over 1 year, and the JSW differences between damaged and undamaged joints as evaluated by the JSN. Results Based on 576 joints of 96 patients with eRA, a significant reduction from baseline to 1 year was observed in the JSW from 1.69 (±0.19) mm to 1.66 (±0.19) mm (p<0.01), and BMD from 0.583 (±0.068) g/cm 2 to 0.566 (±0.074) g/cm 2 (p<0.01). A significant positive association was observed between ΔJSW and ΔBMD over 1 year (p<0.0001). On an individual joint level, JSWs of undamaged (JSN=0) joints were wider than damaged (JSN>0) joints: 1.68 mm (95% CI 1.70 to 1.67) vs 1.54 mm (95% CI 1.63 to 1.46). Similarly the unadjusted multilevel model showed significant differences in JSW between undamaged (1.68 mm (95% CI 1.72 to 1.64)) and damaged joints (1.63 mm (95% CI 1.68 to 1.58)) (p=0.0048). This difference remained significant in the adjusted model: 1.66 mm (95% CI 1.70 to 1.61) vs 1.62 mm (95% CI 1.68 to 1.56) (p=0.042). Conclusions To measure the JSW with this fully automated digital tool may be useful as a quick and observer-independent application for evaluating cartilage damage in eRA. Trial registration number NCT00764725.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Automated, Bone Mineral Density, Joint Space Width, Radiographic scoring, Rheumatoid Arthritis
in
RMD Open
volume
3
issue
1
publisher
BMJ Publishing Group
external identifiers
  • scopus:85021649995
ISSN
2056-5933
DOI
10.1136/rmdopen-2016-000369
language
English
LU publication?
yes
id
c0d919b7-56e9-4e33-90d5-2e3251feb9cd
date added to LUP
2017-08-17 15:11:04
date last changed
2017-08-17 15:11:04
@article{c0d919b7-56e9-4e33-90d5-2e3251feb9cd,
  abstract     = {<p>Objectives To study fully automated digital joint space width (JSW) and bone mineral density (BMD) in relation to a conventional radiographic scoring method in early rheumatoid arthritis (eRA). Methods Radiographs scored by the modified Sharp van der Heijde score (SHS) in patients with eRA were acquired from the SWEdish FarmacOTherapy study. Fully automated JSW measurements of bilateral metacarpals 2, 3 and 4 were compared with the joint space narrowing (JSN) score in SHS. Multilevel mixed model statistics were applied to calculate the significance of the association between ΔJSW and ΔBMD over 1 year, and the JSW differences between damaged and undamaged joints as evaluated by the JSN. Results Based on 576 joints of 96 patients with eRA, a significant reduction from baseline to 1 year was observed in the JSW from 1.69 (±0.19) mm to 1.66 (±0.19) mm (p&lt;0.01), and BMD from 0.583 (±0.068) g/cm 2 to 0.566 (±0.074) g/cm 2 (p&lt;0.01). A significant positive association was observed between ΔJSW and ΔBMD over 1 year (p&lt;0.0001). On an individual joint level, JSWs of undamaged (JSN=0) joints were wider than damaged (JSN&gt;0) joints: 1.68 mm (95% CI 1.70 to 1.67) vs 1.54 mm (95% CI 1.63 to 1.46). Similarly the unadjusted multilevel model showed significant differences in JSW between undamaged (1.68 mm (95% CI 1.72 to 1.64)) and damaged joints (1.63 mm (95% CI 1.68 to 1.58)) (p=0.0048). This difference remained significant in the adjusted model: 1.66 mm (95% CI 1.70 to 1.61) vs 1.62 mm (95% CI 1.68 to 1.56) (p=0.042). Conclusions To measure the JSW with this fully automated digital tool may be useful as a quick and observer-independent application for evaluating cartilage damage in eRA. Trial registration number NCT00764725.</p>},
  articleno    = {e000369},
  author       = {Platten, Michael and Kisten, Yogan and Kälvesten, Johan and Arnaud, Laurent and Forslind, Kristina and van Vollenhoven, Ronald},
  issn         = {2056-5933},
  keyword      = {Automated,Bone Mineral Density,Joint Space Width,Radiographic scoring,Rheumatoid Arthritis},
  language     = {eng},
  number       = {1},
  publisher    = {BMJ Publishing Group},
  series       = {RMD Open},
  title        = {Fully automated joint space width measurement and digital X-ray radiogrammetry in early RA},
  url          = {http://dx.doi.org/10.1136/rmdopen-2016-000369},
  volume       = {3},
  year         = {2017},
}