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Low lung function and the risk of incident chronic kidney disease in the Malmö Preventive Project cohort

Zaigham, Suneela LU ; Christensson, Anders LU ; Wollmer, Per LU and Engström, Gunnar LU (2020) In BMC Nephrology 21(1).
Abstract

Background: Although the prevalence of kidney disease is higher in those with reduced lung function, the longitudinal relationship between low lung function and future risk of chronic kidney disease (CKD) has not been widely explored. Methods: Baseline lung function was assessed in 20,700 men and 7325 women from 1974 to 1992. Mean age was 43.4 (±6.6) and 47.5 (±7.9) for men and women respectively. Sex-specific quartiles of FEV1 and FVC (L) were created (Q4: highest, reference) and the cohort was also divided by the FEV1/FVC ratio (≥ or < 0.70). Cox proportional hazards regression was used to determine the risk of incident CKD events (inpatient or outpatient hospital diagnosis of CKD) in relation to baseline lung... (More)

Background: Although the prevalence of kidney disease is higher in those with reduced lung function, the longitudinal relationship between low lung function and future risk of chronic kidney disease (CKD) has not been widely explored. Methods: Baseline lung function was assessed in 20,700 men and 7325 women from 1974 to 1992. Mean age was 43.4 (±6.6) and 47.5 (±7.9) for men and women respectively. Sex-specific quartiles of FEV1 and FVC (L) were created (Q4: highest, reference) and the cohort was also divided by the FEV1/FVC ratio (≥ or < 0.70). Cox proportional hazards regression was used to determine the risk of incident CKD events (inpatient or outpatient hospital diagnosis of CKD) in relation to baseline lung function after adjustment for various confounding factors. Results: Over 41 years of follow-up there were 710 and 165 incident CKD events (main diagnosis) in men and women respectively. Low FEV1 was strongly associated with future risk of CKD in men (Q1 vs Q4 adjusted HR: 1.46 (CI:1.14-1.89), p-trend 0.002). Similar findings were observed for FVC in men (1.51 (CI:1.16-1.95), p-trend 0.001). The adjusted risks were not found to be significant in women, for either FEV1 or FVC. FEV1/FVC < 0.70 was not associated with increased incidence of CKD in men or women. Conclusion: Low FEV1 and FVC levels at baseline are a risk factor for the development of future incident CKD in men. Monitoring kidney function in those with reduced vital capacity in early life could help with identifying those at increased risk of future CKD.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Chronic kidney disease, Cohort, Incidence, Lung function, Spirometry
in
BMC Nephrology
volume
21
issue
1
article number
124
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85083178584
  • pmid:32268898
ISSN
1471-2369
DOI
10.1186/s12882-020-01758-0
language
English
LU publication?
yes
id
c0daa567-fcce-49ef-9c2d-fc7ba5ee8462
date added to LUP
2020-05-04 11:13:27
date last changed
2024-06-13 16:28:40
@article{c0daa567-fcce-49ef-9c2d-fc7ba5ee8462,
  abstract     = {{<p>Background: Although the prevalence of kidney disease is higher in those with reduced lung function, the longitudinal relationship between low lung function and future risk of chronic kidney disease (CKD) has not been widely explored. Methods: Baseline lung function was assessed in 20,700 men and 7325 women from 1974 to 1992. Mean age was 43.4 (±6.6) and 47.5 (±7.9) for men and women respectively. Sex-specific quartiles of FEV<sub>1</sub> and FVC (L) were created (Q4: highest, reference) and the cohort was also divided by the FEV<sub>1</sub>/FVC ratio (≥ or &lt; 0.70). Cox proportional hazards regression was used to determine the risk of incident CKD events (inpatient or outpatient hospital diagnosis of CKD) in relation to baseline lung function after adjustment for various confounding factors. Results: Over 41 years of follow-up there were 710 and 165 incident CKD events (main diagnosis) in men and women respectively. Low FEV<sub>1</sub> was strongly associated with future risk of CKD in men (Q1 vs Q4 adjusted HR: 1.46 (CI:1.14-1.89), p-trend 0.002). Similar findings were observed for FVC in men (1.51 (CI:1.16-1.95), p-trend 0.001). The adjusted risks were not found to be significant in women, for either FEV<sub>1</sub> or FVC. FEV<sub>1</sub>/FVC &lt; 0.70 was not associated with increased incidence of CKD in men or women. Conclusion: Low FEV<sub>1</sub> and FVC levels at baseline are a risk factor for the development of future incident CKD in men. Monitoring kidney function in those with reduced vital capacity in early life could help with identifying those at increased risk of future CKD.</p>}},
  author       = {{Zaigham, Suneela and Christensson, Anders and Wollmer, Per and Engström, Gunnar}},
  issn         = {{1471-2369}},
  keywords     = {{Chronic kidney disease; Cohort; Incidence; Lung function; Spirometry}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{BMC Nephrology}},
  title        = {{Low lung function and the risk of incident chronic kidney disease in the Malmö Preventive Project cohort}},
  url          = {{http://dx.doi.org/10.1186/s12882-020-01758-0}},
  doi          = {{10.1186/s12882-020-01758-0}},
  volume       = {{21}},
  year         = {{2020}},
}