Advanced

Effect of more vs less frequent follow-up testing on overall and colorectal cancer–Specific mortality in patients with stage II or III colorectal cancer the COLOFOL randomized clinical trial

Wille-Jørgensen, Peer; Syk, Ingvar LU ; Smedh, Kenneth; Laurberg, Søren; Nielsen, Dennis T.; Petersen, Sune H.; Renehan, Andrew G.; Horváth-Puho, Erzsébet; Påhlman, Lars and Sørensen, Henrik T., et al. (2018) In JAMA - Journal of the American Medical Association 319(20). p.2095-2103
Abstract

IMPORTANCE Intensive follow-up of patients after curative surgery for colorectal cancer is common in clinical practice, but evidence of a survival benefit is limited. OBJECTIVE To examine overall mortality, colorectal cancer–specific mortality, and colorectal cancer–specific recurrence rates among patients with stage II or III colorectal cancer who were randomized after curative surgery to 2 alternative schedules for follow-up testing with computed tomography and carcinoembryonic antigen. DESIGN, SETTING, AND PARTICIPANTS Unblinded randomized trial including 2509 patients with stage II or III colorectal cancer treated at 24 centers in Sweden, Denmark, and Uruguay from January 2006 through December 2010 and followed up for 5 years;... (More)

IMPORTANCE Intensive follow-up of patients after curative surgery for colorectal cancer is common in clinical practice, but evidence of a survival benefit is limited. OBJECTIVE To examine overall mortality, colorectal cancer–specific mortality, and colorectal cancer–specific recurrence rates among patients with stage II or III colorectal cancer who were randomized after curative surgery to 2 alternative schedules for follow-up testing with computed tomography and carcinoembryonic antigen. DESIGN, SETTING, AND PARTICIPANTS Unblinded randomized trial including 2509 patients with stage II or III colorectal cancer treated at 24 centers in Sweden, Denmark, and Uruguay from January 2006 through December 2010 and followed up for 5 years; follow-up ended on December 31, 2015. INTERVENTIONS Patients were randomized either to follow-up testing with computed tomography of the thorax and abdomen and serum carcinoembryonic antigen at 6, 12, 18, 24 and 36 months after surgery (high-frequency group; n = 1253 patients) or at 12 and 36 months after surgery (low-frequency group; n = 1256 patients). MAIN OUTCOMES AND MEASURES The primary outcomes were 5-year overall mortality and colorectal cancer–specific mortality rates. The secondary outcome was the colorectal cancer–specific recurrence rate. Both intention-to-treat and per-protocol analyses were performed. RESULTS Among 2555 patients who were randomized, 2509 were included in the intention-to-treat analysis (mean age, 63.5 years; 1128 women [45%]) and 2365 (94.3%) completed the trial. The 5-year overall patient mortality rate in the high-frequency group was 13.0% (161/1253) compared with 14.1% (174/1256) in the low-frequency group (risk difference 1.1% [95% CI, −1.6% to 3.8%]; P = .43). The 5-year colorectal cancer–specific mortality rate in the high-frequency group was 10.6% (128/1248) compared with 11.4% (137/1250) in the low-frequency group (risk difference, 0.8% [95% CI, −1.7% to 3.3%]; P = .52). The colorectal cancer–specific recurrence rate was 21.6% (265/1248) in the high-frequency group compared with 19.4% (238/1250) in the low-frequency group (risk difference, 2.2% [95% CI, −1.0% to 5.4%]; P = .15). CONCLUSIONS AND RELEVANCE Among patients with stage II or III colorectal cancer, follow-u testing with computed tomography and carcinoembryonic antigen more frequently compared with less frequently did not result in a significant rate reduction in 5-year overall mortality or colorectal cancer–specific mortality.

(Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
publishing date
type
Contribution to journal
publication status
published
subject
in
JAMA - Journal of the American Medical Association
volume
319
issue
20
pages
9 pages
publisher
American Medical Association
external identifiers
  • scopus:85047768016
ISSN
0098-7484
DOI
10.1001/jama.2018.5623
language
English
LU publication?
no
id
c0e16c22-7bfd-45bc-8711-ecc46239b590
date added to LUP
2018-06-13 14:42:06
date last changed
2018-07-29 04:34:54
@article{c0e16c22-7bfd-45bc-8711-ecc46239b590,
  abstract     = {<p>IMPORTANCE Intensive follow-up of patients after curative surgery for colorectal cancer is common in clinical practice, but evidence of a survival benefit is limited. OBJECTIVE To examine overall mortality, colorectal cancer–specific mortality, and colorectal cancer–specific recurrence rates among patients with stage II or III colorectal cancer who were randomized after curative surgery to 2 alternative schedules for follow-up testing with computed tomography and carcinoembryonic antigen. DESIGN, SETTING, AND PARTICIPANTS Unblinded randomized trial including 2509 patients with stage II or III colorectal cancer treated at 24 centers in Sweden, Denmark, and Uruguay from January 2006 through December 2010 and followed up for 5 years; follow-up ended on December 31, 2015. INTERVENTIONS Patients were randomized either to follow-up testing with computed tomography of the thorax and abdomen and serum carcinoembryonic antigen at 6, 12, 18, 24 and 36 months after surgery (high-frequency group; n = 1253 patients) or at 12 and 36 months after surgery (low-frequency group; n = 1256 patients). MAIN OUTCOMES AND MEASURES The primary outcomes were 5-year overall mortality and colorectal cancer–specific mortality rates. The secondary outcome was the colorectal cancer–specific recurrence rate. Both intention-to-treat and per-protocol analyses were performed. RESULTS Among 2555 patients who were randomized, 2509 were included in the intention-to-treat analysis (mean age, 63.5 years; 1128 women [45%]) and 2365 (94.3%) completed the trial. The 5-year overall patient mortality rate in the high-frequency group was 13.0% (161/1253) compared with 14.1% (174/1256) in the low-frequency group (risk difference 1.1% [95% CI, −1.6% to 3.8%]; P = .43). The 5-year colorectal cancer–specific mortality rate in the high-frequency group was 10.6% (128/1248) compared with 11.4% (137/1250) in the low-frequency group (risk difference, 0.8% [95% CI, −1.7% to 3.3%]; P = .52). The colorectal cancer–specific recurrence rate was 21.6% (265/1248) in the high-frequency group compared with 19.4% (238/1250) in the low-frequency group (risk difference, 2.2% [95% CI, −1.0% to 5.4%]; P = .15). CONCLUSIONS AND RELEVANCE Among patients with stage II or III colorectal cancer, follow-u testing with computed tomography and carcinoembryonic antigen more frequently compared with less frequently did not result in a significant rate reduction in 5-year overall mortality or colorectal cancer–specific mortality.</p>},
  author       = {Wille-Jørgensen, Peer and Syk, Ingvar and Smedh, Kenneth and Laurberg, Søren and Nielsen, Dennis T. and Petersen, Sune H. and Renehan, Andrew G. and Horváth-Puho, Erzsébet and Påhlman, Lars and Sørensen, Henrik T. and , },
  issn         = {0098-7484},
  language     = {eng},
  month        = {05},
  number       = {20},
  pages        = {2095--2103},
  publisher    = {American Medical Association},
  series       = {JAMA - Journal of the American Medical Association},
  title        = {Effect of more vs less frequent follow-up testing on overall and colorectal cancer–Specific mortality in patients with stage II or III colorectal cancer the COLOFOL randomized clinical trial},
  url          = {http://dx.doi.org/10.1001/jama.2018.5623},
  volume       = {319},
  year         = {2018},
}