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Update on the Protein Homeostasis Network in Bacillus subtilis

Matavacas, Judith LU and von Wachenfeldt, Claes LU (2022) In Frontiers in Microbiology 13.
Abstract

Protein homeostasis is fundamental to cell function and survival. It relies on an interconnected network of processes involving protein synthesis, folding, post-translational modification and degradation as well as regulators of these processes. Here we provide an update on the roles, regulation and subcellular localization of the protein homeostasis machinery in the Gram-positive model organism Bacillus subtilis. We discuss emerging ideas and current research gaps in the field that, if tackled, increase our understanding of how Gram-positive bacteria, including several human pathogens, maintain protein homeostasis and cope with stressful conditions that challenge their survival.

Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
chaperone, degradation tags, protease, protein aggregation, protein quality control, proteotoxic stress
in
Frontiers in Microbiology
volume
13
article number
865141
publisher
Frontiers Media S. A.
external identifiers
  • pmid:35350626
  • scopus:85127303780
ISSN
1664-302X
DOI
10.3389/fmicb.2022.865141
language
English
LU publication?
yes
id
c0e4de7c-6f53-41b0-a74a-fc534847dbf3
date added to LUP
2022-05-04 12:06:11
date last changed
2025-04-04 17:51:26
@article{c0e4de7c-6f53-41b0-a74a-fc534847dbf3,
  abstract     = {{<p>Protein homeostasis is fundamental to cell function and survival. It relies on an interconnected network of processes involving protein synthesis, folding, post-translational modification and degradation as well as regulators of these processes. Here we provide an update on the roles, regulation and subcellular localization of the protein homeostasis machinery in the Gram-positive model organism Bacillus subtilis. We discuss emerging ideas and current research gaps in the field that, if tackled, increase our understanding of how Gram-positive bacteria, including several human pathogens, maintain protein homeostasis and cope with stressful conditions that challenge their survival.</p>}},
  author       = {{Matavacas, Judith and von Wachenfeldt, Claes}},
  issn         = {{1664-302X}},
  keywords     = {{chaperone; degradation tags; protease; protein aggregation; protein quality control; proteotoxic stress}},
  language     = {{eng}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Microbiology}},
  title        = {{Update on the Protein Homeostasis Network in Bacillus subtilis}},
  url          = {{http://dx.doi.org/10.3389/fmicb.2022.865141}},
  doi          = {{10.3389/fmicb.2022.865141}},
  volume       = {{13}},
  year         = {{2022}},
}