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Transcatheter Intervention for Coarctation of the Aorta : A Nordic Population-Based Registry With Long-Term Follow-Up

Eriksson, Peter ; Pihkala, Jaana ; Jensen, Annette S. ; Dohlen, Gaute ; Liuba, Petru LU ; Wahlander, Hakan ; Sjoberg, Gunnar ; Hlebowicz, Joanna LU ; Furenas, Eva and Leirgul, Elisabeth , et al. (2023) In JACC: Cardiovascular Interventions 16(4). p.444-453
Abstract

Background: Coarctation of the aorta (CoA), a congenital narrowing of the proximal descending thoracic aorta, is a relatively common form of congenital heart disease. Untreated significant CoA has a major impact on morbidity and mortality. In the past 3 decades, transcatheter intervention (TCI) for CoA has evolved as an alternative to surgery. Objectives: The authors report on all TCIs for CoA performed from 2000 to 2016 in 4 countries covering 25 million inhabitants, with a mean follow-up duration of 6.9 years. Methods: During the study period, 683 interventions were performed on 542 patients. Results: The procedural success rate was 88%, with 9% considered partly successful. Complications at the intervention site occurred in 3.5% of... (More)

Background: Coarctation of the aorta (CoA), a congenital narrowing of the proximal descending thoracic aorta, is a relatively common form of congenital heart disease. Untreated significant CoA has a major impact on morbidity and mortality. In the past 3 decades, transcatheter intervention (TCI) for CoA has evolved as an alternative to surgery. Objectives: The authors report on all TCIs for CoA performed from 2000 to 2016 in 4 countries covering 25 million inhabitants, with a mean follow-up duration of 6.9 years. Methods: During the study period, 683 interventions were performed on 542 patients. Results: The procedural success rate was 88%, with 9% considered partly successful. Complications at the intervention site occurred in 3.5% of interventions and at the access site in 3.5%. There was no in-hospital mortality. During follow-up, TCI for CoA reduced the presence of hypertension significantly from 73% to 34%, but despite this, many patients remained hypertensive and in need of continuous antihypertensive treatment. Moreover, 8% to 9% of patients needed aortic and/or aortic valve surgery during follow-up. Conclusions: TCI for CoA can be performed with a low risk for complications. Lifetime follow-up after TCI for CoA seems warranted.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
catheter intervention, coarctation of Aorta, congenital heart disease
in
JACC: Cardiovascular Interventions
volume
16
issue
4
pages
444 - 453
publisher
Elsevier
external identifiers
  • pmid:36858664
  • scopus:85148647929
ISSN
1936-8798
DOI
10.1016/j.jcin.2022.11.007
language
English
LU publication?
no
id
c14b4d88-90cd-4166-a8e3-b6e12a00a624
date added to LUP
2023-03-15 12:53:55
date last changed
2024-10-30 23:05:53
@article{c14b4d88-90cd-4166-a8e3-b6e12a00a624,
  abstract     = {{<p>Background: Coarctation of the aorta (CoA), a congenital narrowing of the proximal descending thoracic aorta, is a relatively common form of congenital heart disease. Untreated significant CoA has a major impact on morbidity and mortality. In the past 3 decades, transcatheter intervention (TCI) for CoA has evolved as an alternative to surgery. Objectives: The authors report on all TCIs for CoA performed from 2000 to 2016 in 4 countries covering 25 million inhabitants, with a mean follow-up duration of 6.9 years. Methods: During the study period, 683 interventions were performed on 542 patients. Results: The procedural success rate was 88%, with 9% considered partly successful. Complications at the intervention site occurred in 3.5% of interventions and at the access site in 3.5%. There was no in-hospital mortality. During follow-up, TCI for CoA reduced the presence of hypertension significantly from 73% to 34%, but despite this, many patients remained hypertensive and in need of continuous antihypertensive treatment. Moreover, 8% to 9% of patients needed aortic and/or aortic valve surgery during follow-up. Conclusions: TCI for CoA can be performed with a low risk for complications. Lifetime follow-up after TCI for CoA seems warranted.</p>}},
  author       = {{Eriksson, Peter and Pihkala, Jaana and Jensen, Annette S. and Dohlen, Gaute and Liuba, Petru and Wahlander, Hakan and Sjoberg, Gunnar and Hlebowicz, Joanna and Furenas, Eva and Leirgul, Elisabeth and Settergren, Magnus and Vithessonthi, Kanyalak and Nielsen, Niels Erik and Christersson, Christina and Sondergaard, Lars and Sinisalo, Juha and Nielsen-Kudsk, Jens Erik and Dellborg, Mikael and Larsen, Signe H.}},
  issn         = {{1936-8798}},
  keywords     = {{catheter intervention; coarctation of Aorta; congenital heart disease}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{4}},
  pages        = {{444--453}},
  publisher    = {{Elsevier}},
  series       = {{JACC: Cardiovascular Interventions}},
  title        = {{Transcatheter Intervention for Coarctation of the Aorta : A Nordic Population-Based Registry With Long-Term Follow-Up}},
  url          = {{http://dx.doi.org/10.1016/j.jcin.2022.11.007}},
  doi          = {{10.1016/j.jcin.2022.11.007}},
  volume       = {{16}},
  year         = {{2023}},
}