Testosterone Level and Risk of Diabetes: Follow-Up Study
Rezanezhad, Babak ; Borgquist, Rasmus LU
and Elzanaty, Saad
LU
(2023)
In Medical Research Archives
11(9).
- Abstract
- Background: Epidemiological studies have documented an inverse relationship between testosterone levels and risk of cardiovascular disease. The present study aimed to explore the association between testosterone levels and risk of developing diabetes mellitus from 108 middle-aged men with no history of medical diseases.
Methods: Data regarding the age of subjects, smoking, alcohol consumption, waist-to-hip ratio, and family history of cardiovascular disease were collected at the time of inclusion. Testosterone levels were also measured. 15 years later the medical history of the men was reviewed to record the development of medical incidents with references to diabetes mellitus. Two groups of men were identified based on testosterone... (More) - Background: Epidemiological studies have documented an inverse relationship between testosterone levels and risk of cardiovascular disease. The present study aimed to explore the association between testosterone levels and risk of developing diabetes mellitus from 108 middle-aged men with no history of medical diseases.
Methods: Data regarding the age of subjects, smoking, alcohol consumption, waist-to-hip ratio, and family history of cardiovascular disease were collected at the time of inclusion. Testosterone levels were also measured. 15 years later the medical history of the men was reviewed to record the development of medical incidents with references to diabetes mellitus. Two groups of men were identified based on testosterone levels: hypogonadal (testosterone ≤12 nmol/L) and eugonadal (testosterone >12 nmol/L).
Results: In total, 10 (9.0%) out of 108 men developed diabetes during the 15-year follow-up period, of whom 6 (16%) out of 37 and 4 (6%) out of 71 were men in the hypogonadal and eugonadal cohorts respectively (p=0.08). Using Cox proportional hazards regression analysis, the adjusted risk for diabetes was significantly lower in eugonadal men compared to hypogonadal men (adjusted hazard ratio=0.236; 95% CI=0.062–0.898; P=0.03).
Conclusion: Our results showed a significant increased risk of diabetes in men with low testosterone levels compared to men with normal testosterone. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/c15ad5c3-ccc9-4b69-869d-7f8323314e82
- author
- Rezanezhad, Babak
; Borgquist, Rasmus
LU
and Elzanaty, Saad
LU
- organization
- publishing date
- 2023-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Medical Research Archives
- volume
- 11
- issue
- 9
- article number
- 4473
- publisher
- European Society of Medicine
- ISSN
- 2375-1916
- DOI
- 10.18103/mra.v11i9.4473
- language
- English
- LU publication?
- yes
- id
- c15ad5c3-ccc9-4b69-869d-7f8323314e82
- date added to LUP
- 2023-10-09 08:42:35
- date last changed
- 2023-10-09 08:42:35
@article{c15ad5c3-ccc9-4b69-869d-7f8323314e82,
abstract = {{Background: Epidemiological studies have documented an inverse relationship between testosterone levels and risk of cardiovascular disease. The present study aimed to explore the association between testosterone levels and risk of developing diabetes mellitus from 108 middle-aged men with no history of medical diseases.<br/>Methods: Data regarding the age of subjects, smoking, alcohol consumption, waist-to-hip ratio, and family history of cardiovascular disease were collected at the time of inclusion. Testosterone levels were also measured. 15 years later the medical history of the men was reviewed to record the development of medical incidents with references to diabetes mellitus. Two groups of men were identified based on testosterone levels: hypogonadal (testosterone ≤12 nmol/L) and eugonadal (testosterone >12 nmol/L).<br/>Results: In total, 10 (9.0%) out of 108 men developed diabetes during the 15-year follow-up period, of whom 6 (16%) out of 37 and 4 (6%) out of 71 were men in the hypogonadal and eugonadal cohorts respectively (p=0.08). Using Cox proportional hazards regression analysis, the adjusted risk for diabetes was significantly lower in eugonadal men compared to hypogonadal men (adjusted hazard ratio=0.236; 95% CI=0.062–0.898; P=0.03).<br/>Conclusion: Our results showed a significant increased risk of diabetes in men with low testosterone levels compared to men with normal testosterone.}},
author = {{Rezanezhad, Babak and Borgquist, Rasmus and Elzanaty, Saad}},
issn = {{2375-1916}},
language = {{eng}},
month = {{01}},
number = {{9}},
publisher = {{European Society of Medicine}},
series = {{Medical Research Archives}},
title = {{Testosterone Level and Risk of Diabetes: Follow-Up Study}},
url = {{http://dx.doi.org/10.18103/mra.v11i9.4473}},
doi = {{10.18103/mra.v11i9.4473}},
volume = {{11}},
year = {{2023}},
}