Association Between Testosterone Levels and Clinical Markers of Atherosclerosis
Rezanezhad Zanjani, Babak LU ; Borgquist, Rasmus LU
and Elzanaty, Saad
LU
(2020)
In Journal of Clinical and Medical Images
4(6).
- Abstract
- 1.1. Objectives: To investigate the association between testosterone levels and parameters obtainedfrom the clinical exercise stress test from 119 middle-aged Swedish men.1.2. Material and Methods: All subjects underwent a clinical exercise stress test and data on maximalheart rate, systolic pressure, diastolic pressure; and ST-segment levels in lead augmented vector foot(lead aVF) and lead left precordial voltage 5 (lead v5) were collected. Serum testosterone levels weremeasured. Data on age, body mass index (BMI), smoking, alcohol consumption, and family historyof cardiovascular diseases (CVD) were gathered. Men were classified into two groups: hypogonadal(testosterone ≤ 12 nmol/L), and eugonadal (testosterone > 12 nmol/L).1.3.... (More)
- 1.1. Objectives: To investigate the association between testosterone levels and parameters obtainedfrom the clinical exercise stress test from 119 middle-aged Swedish men.1.2. Material and Methods: All subjects underwent a clinical exercise stress test and data on maximalheart rate, systolic pressure, diastolic pressure; and ST-segment levels in lead augmented vector foot(lead aVF) and lead left precordial voltage 5 (lead v5) were collected. Serum testosterone levels weremeasured. Data on age, body mass index (BMI), smoking, alcohol consumption, and family historyof cardiovascular diseases (CVD) were gathered. Men were classified into two groups: hypogonadal(testosterone ≤ 12 nmol/L), and eugonadal (testosterone > 12 nmol/L).1.3. Results: We found a significant negative correlation between testosterone and maximal systolicpressure (r= -0.30, P=0.01). Hypogonadal men had significantly higher systolic pressure and moredepressed ST-segment in lead V5 compared to eugonadal men (225mmHg vs. 210mmHg; p=0.01),(-0.13mm vs. 0.27mm; p=0.04), respectively. In a multivariate regression analysis test adjusted for theage of subjects, BMI, smoking, alcohol consumption, and family history of CVD, a significant negativeassociation was found only between testosterone and maximal systolic pressure (β= -0.829, p=0.04,95% CI= -1.636, -0.022).1.4. Conclusions: Our findings of an inverse relationship between testosterone levels and parametersof clinical stress test suggest that low testosterone may be a cardiovascular risk factor. (Less)
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- author
- Rezanezhad Zanjani, Babak
LU
; Borgquist, Rasmus
LU
and Elzanaty, Saad
LU
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Clinical and Medical Images
- volume
- 4
- issue
- 6
- publisher
- Journal of Clinical and Medical Images
- ISSN
- 2640-9615
- language
- English
- LU publication?
- yes
- id
- c1820638-2635-4ddb-a5af-9fbee8cb10f5
- date added to LUP
- 2020-12-21 13:56:41
- date last changed
- 2020-12-22 02:24:25
@article{c1820638-2635-4ddb-a5af-9fbee8cb10f5,
abstract = {{1.1. Objectives: To investigate the association between testosterone levels and parameters obtainedfrom the clinical exercise stress test from 119 middle-aged Swedish men.1.2. Material and Methods: All subjects underwent a clinical exercise stress test and data on maximalheart rate, systolic pressure, diastolic pressure; and ST-segment levels in lead augmented vector foot(lead aVF) and lead left precordial voltage 5 (lead v5) were collected. Serum testosterone levels weremeasured. Data on age, body mass index (BMI), smoking, alcohol consumption, and family historyof cardiovascular diseases (CVD) were gathered. Men were classified into two groups: hypogonadal(testosterone ≤ 12 nmol/L), and eugonadal (testosterone > 12 nmol/L).1.3. Results: We found a significant negative correlation between testosterone and maximal systolicpressure (r= -0.30, P=0.01). Hypogonadal men had significantly higher systolic pressure and moredepressed ST-segment in lead V5 compared to eugonadal men (225mmHg vs. 210mmHg; p=0.01),(-0.13mm vs. 0.27mm; p=0.04), respectively. In a multivariate regression analysis test adjusted for theage of subjects, BMI, smoking, alcohol consumption, and family history of CVD, a significant negativeassociation was found only between testosterone and maximal systolic pressure (β= -0.829, p=0.04,95% CI= -1.636, -0.022).1.4. Conclusions: Our findings of an inverse relationship between testosterone levels and parametersof clinical stress test suggest that low testosterone may be a cardiovascular risk factor.}},
author = {{Rezanezhad Zanjani, Babak and Borgquist, Rasmus and Elzanaty, Saad}},
issn = {{2640-9615}},
language = {{eng}},
number = {{6}},
publisher = {{Journal of Clinical and Medical Images}},
series = {{Journal of Clinical and Medical Images}},
title = {{Association Between Testosterone Levels and Clinical Markers of Atherosclerosis}},
volume = {{4}},
year = {{2020}},
}