Prenatal and postnatal PCB-153 and p,p′ -DDE exposures and behavior scores at 5–9 years of age among children in Greenland and Ukraine
(2017) In Environmental Health Perspectives 125(10).- Abstract
BACKGROUND: Studies have reported some evidence of adverse effects of organochlorine exposures on child development, but the results have been inconsistent, and few studies have evaluated associations with child behavior. OBJECTIVE: We investigated the association between prenatal and early-life exposures to 2,2′,4,4′,5,5′ -hexachlorobiphenyl (PCB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p′ -DDE) and behaviors in children between 5 and 9 y of age. METHODS: In the Biopersistent organochlorines in diet and human fertility: Epidemiologic studies of time to pregnancy and semen quality in Inuit and European populations (INUENDO) cohort, consisting of mother–child pairs from Greenland and Ukraine (n = 1,018), maternal serum... (More)
BACKGROUND: Studies have reported some evidence of adverse effects of organochlorine exposures on child development, but the results have been inconsistent, and few studies have evaluated associations with child behavior. OBJECTIVE: We investigated the association between prenatal and early-life exposures to 2,2′,4,4′,5,5′ -hexachlorobiphenyl (PCB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p′ -DDE) and behaviors in children between 5 and 9 y of age. METHODS: In the Biopersistent organochlorines in diet and human fertility: Epidemiologic studies of time to pregnancy and semen quality in Inuit and European populations (INUENDO) cohort, consisting of mother–child pairs from Greenland and Ukraine (n = 1,018), maternal serum PCB-153 and p,p′ -DDE concentrations were measured during pregnancy, and cumulative postnatal exposures during the first 12 months after delivery were estimated using a pharmacokinetic model. Parents completed the Strengths and Difficulties Questionnaire (SDQ), and children’s behaviors were dichotomized as abnormal (high) versus normal/borderline for five SDQ subscales and the total difficulties score. RESULTS: The total difficulties score, an overall measure of abnormal behavior, was not clearly associated with pre- or postnatal exposures to PCB-153 or to p,p′ -DDE. However, pooled adjusted odds ratios (ORs) for high conduct problem scores with a doubling of exposure were 1.19 (95% CI: 0.99, 1.42) and 1.16 (95% CI: 0.96, 1.41) for pre- and postnatal PCB-153, respectively, and 1.25 (95% CI: 1.04, 1.51) and 1.24 (95% CI: 1.01, 1.51) for pre-and postnatal p,p′ -DDE, respectively. Corresponding ORs for high hyperactivity scores were 1.24 (95% CI: 0.94, 1.62) and 1.08 (95% CI: 0.81, 1.45) for pre- and postnatal PCB-153, respectively, and 1.43 (95% CI: 1.06, 1.92) and 1.27 (95% CI: 0.93, 1.73) for pre- and postnatal p,p′ -DDE, respectively. CONCLUSION: Prenatal and early postnatal exposures to p,p′ -DDE and PCB-153 were associated with a higher prevalence of abnormal scores for conduct and hyperactivity at 5–9 y of age in our study population. These findings provide further support for the importance of minimizing organochlorine exposures to young children and to women of childbearing age.
(Less)
- author
- Rosenquist, Aske Hess ; Høyer, Birgit Bjerre ; Julvez, Jordi ; Sunyer, Jordi ; Pedersen, Henning Sloth ; Lenters, Virissa ; Jönsson, Bo A.G. LU ; Bonde, Jens Peter and Toft, Gunnar
- organization
- publishing date
- 2017-10-03
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Environmental Health Perspectives
- volume
- 125
- issue
- 10
- article number
- 107002
- publisher
- National Institute of Environmental Health Sciences
- external identifiers
-
- pmid:28974479
- wos:000413793300014
- scopus:85031748247
- ISSN
- 0091-6765
- DOI
- 10.1289/EHP553
- language
- English
- LU publication?
- yes
- id
- c18f34c7-91fd-46aa-8753-bb8004393720
- date added to LUP
- 2017-11-20 12:37:05
- date last changed
- 2025-01-08 00:33:11
@article{c18f34c7-91fd-46aa-8753-bb8004393720,
abstract = {{<p>BACKGROUND: Studies have reported some evidence of adverse effects of organochlorine exposures on child development, but the results have been inconsistent, and few studies have evaluated associations with child behavior. OBJECTIVE: We investigated the association between prenatal and early-life exposures to 2,2′,4,4′,5,5′ -hexachlorobiphenyl (PCB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p′ -DDE) and behaviors in children between 5 and 9 y of age. METHODS: In the Biopersistent organochlorines in diet and human fertility: Epidemiologic studies of time to pregnancy and semen quality in Inuit and European populations (INUENDO) cohort, consisting of mother–child pairs from Greenland and Ukraine (n = 1,018), maternal serum PCB-153 and p,p′ -DDE concentrations were measured during pregnancy, and cumulative postnatal exposures during the first 12 months after delivery were estimated using a pharmacokinetic model. Parents completed the Strengths and Difficulties Questionnaire (SDQ), and children’s behaviors were dichotomized as abnormal (high) versus normal/borderline for five SDQ subscales and the total difficulties score. RESULTS: The total difficulties score, an overall measure of abnormal behavior, was not clearly associated with pre- or postnatal exposures to PCB-153 or to p,p′ -DDE. However, pooled adjusted odds ratios (ORs) for high conduct problem scores with a doubling of exposure were 1.19 (95% CI: 0.99, 1.42) and 1.16 (95% CI: 0.96, 1.41) for pre- and postnatal PCB-153, respectively, and 1.25 (95% CI: 1.04, 1.51) and 1.24 (95% CI: 1.01, 1.51) for pre-and postnatal p,p′ -DDE, respectively. Corresponding ORs for high hyperactivity scores were 1.24 (95% CI: 0.94, 1.62) and 1.08 (95% CI: 0.81, 1.45) for pre- and postnatal PCB-153, respectively, and 1.43 (95% CI: 1.06, 1.92) and 1.27 (95% CI: 0.93, 1.73) for pre- and postnatal p,p′ -DDE, respectively. CONCLUSION: Prenatal and early postnatal exposures to p,p′ -DDE and PCB-153 were associated with a higher prevalence of abnormal scores for conduct and hyperactivity at 5–9 y of age in our study population. These findings provide further support for the importance of minimizing organochlorine exposures to young children and to women of childbearing age.</p>}},
author = {{Rosenquist, Aske Hess and Høyer, Birgit Bjerre and Julvez, Jordi and Sunyer, Jordi and Pedersen, Henning Sloth and Lenters, Virissa and Jönsson, Bo A.G. and Bonde, Jens Peter and Toft, Gunnar}},
issn = {{0091-6765}},
language = {{eng}},
month = {{10}},
number = {{10}},
publisher = {{National Institute of Environmental Health Sciences}},
series = {{Environmental Health Perspectives}},
title = {{Prenatal and postnatal PCB-153 and p,p′ -DDE exposures and behavior scores at 5–9 years of age among children in Greenland and Ukraine}},
url = {{http://dx.doi.org/10.1289/EHP553}},
doi = {{10.1289/EHP553}},
volume = {{125}},
year = {{2017}},
}