Familial and neighborhood effects on psychiatric disorders in childhood and adolescence
Sundquist, Jan LU ; Li, Xinjun LU ; Ohlsson, Henrik LU ; Råstam, Maria LU
; Winkleby, Marilyn
; Sundquist, Kristina
LU
; Kendler, Kenneth S
and Crump, Casey
(2015)
In Journal of Psychiatric Research
66-67.
p.7-15
- Abstract
- Background:
More knowledge is needed on potential associations between individual-, family-, and neighborhood-level factors and psychiatric disorders in children and adolescents.
Aims:
To examine associations between, individual-, family-, and neighborhood-level factors and incident internalizing (anxiety and mood) disorders and externalizing (ADHD and conduct) disorders in children and adolescents, and to estimate the relative contributions of family and neighborhood to individual variation in these disorders.
Method:
We performed a three-level logistic regression on all 542,195 children born in Sweden in 1992-1996, nested in 427,954 families, which in turn were nested in... (More) - Background:
More knowledge is needed on potential associations between individual-, family-, and neighborhood-level factors and psychiatric disorders in children and adolescents.
Aims:
To examine associations between, individual-, family-, and neighborhood-level factors and incident internalizing (anxiety and mood) disorders and externalizing (ADHD and conduct) disorders in children and adolescents, and to estimate the relative contributions of family and neighborhood to individual variation in these disorders.
Method:
We performed a three-level logistic regression on all 542,195 children born in Sweden in 1992-1996, nested in 427,954 families, which in turn were nested in 8475 neighborhoods. The children were followed from 2000 to 2010 for incident internalizing and externalizing psychiatric disorders, assessed from medical records.
Results:
26,514 children (4.8%) were diagnosed with internalizing or externalizing psychiatric disorders. Approximately 29% of the total individual variance in internalizing disorders could be attributed to the family level, which includes both genetic and family environmental effects, and 5% to the neighborhood level. The corresponding figures for externalizing disorders were 43.5% and 5.5%, respectively. After adjustment for individual-level sociodemographic factors, high neighborhood deprivationwas associated with increased risks of externalizing and internalizing psychiatric disorders (odds ratio [OR] = 1.37, 95% credible interval [CI] = 1.25-1.50 and OR = 1.34, 95% CI = 1.25-1.45, respectively), including conduct disorder (OR = 2.01, 95% CI = 1.58-2.55), anxiety disorders (OR = 1.40, 95% CI = 1.29-1.52), and mood disorders (OR = 1.21, 95% CI, 1.09-1.35). The strongest association between neighborhood deprivation and ADHD was observed in moderately deprived neighborhoods (OR = 1.31, 95% CI = 1.19-1.44).
Conclusions:
These findings call for policies to promote mental health that consider potential influences from children's family and neighborhood environments.
Trial registration: Not applicable. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5424191
- author
- Sundquist, Jan
LU
; Li, Xinjun
LU
; Ohlsson, Henrik
LU
; Råstam, Maria
LU
; Winkleby, Marilyn
; Sundquist, Kristina
LU
; Kendler, Kenneth S
and Crump, Casey
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cohort study, Neighborhood SES, Internalizing and externalizing psychiatric disorders
- in
- Journal of Psychiatric Research
- volume
- 66-67
- pages
- 7 - 15
- publisher
- Elsevier
- external identifiers
-
- wos:000356746700002
- pmid:25953099
- scopus:84930537405
- pmid:25953099
- ISSN
- 1879-1379
- DOI
- 10.1016/j.jpsychires.2015.03.019
- language
- English
- LU publication?
- yes
- id
- c1a4212f-2f21-4c2b-9a9a-3f4dab9a996a (old id 5424191)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25953099?dopt=Abstract
- date added to LUP
- 2016-04-01 11:07:16
- date last changed
- 2022-04-05 00:16:41
@article{c1a4212f-2f21-4c2b-9a9a-3f4dab9a996a,
abstract = {{Background: <br/><br>
More knowledge is needed on potential associations between individual-, family-, and neighborhood-level factors and psychiatric disorders in children and adolescents.<br/><br>
<br/><br>
Aims: <br/><br>
To examine associations between, individual-, family-, and neighborhood-level factors and incident internalizing (anxiety and mood) disorders and externalizing (ADHD and conduct) disorders in children and adolescents, and to estimate the relative contributions of family and neighborhood to individual variation in these disorders.<br/><br>
<br/><br>
Method:<br/><br>
We performed a three-level logistic regression on all 542,195 children born in Sweden in 1992-1996, nested in 427,954 families, which in turn were nested in 8475 neighborhoods. The children were followed from 2000 to 2010 for incident internalizing and externalizing psychiatric disorders, assessed from medical records.<br/><br>
<br/><br>
Results: <br/><br>
26,514 children (4.8%) were diagnosed with internalizing or externalizing psychiatric disorders. Approximately 29% of the total individual variance in internalizing disorders could be attributed to the family level, which includes both genetic and family environmental effects, and 5% to the neighborhood level. The corresponding figures for externalizing disorders were 43.5% and 5.5%, respectively. After adjustment for individual-level sociodemographic factors, high neighborhood deprivationwas associated with increased risks of externalizing and internalizing psychiatric disorders (odds ratio [OR] = 1.37, 95% credible interval [CI] = 1.25-1.50 and OR = 1.34, 95% CI = 1.25-1.45, respectively), including conduct disorder (OR = 2.01, 95% CI = 1.58-2.55), anxiety disorders (OR = 1.40, 95% CI = 1.29-1.52), and mood disorders (OR = 1.21, 95% CI, 1.09-1.35). The strongest association between neighborhood deprivation and ADHD was observed in moderately deprived neighborhoods (OR = 1.31, 95% CI = 1.19-1.44).<br/><br>
<br/><br>
Conclusions: <br/><br>
These findings call for policies to promote mental health that consider potential influences from children's family and neighborhood environments.<br/><br>
<br/><br>
Trial registration: Not applicable.}},
author = {{Sundquist, Jan and Li, Xinjun and Ohlsson, Henrik and Råstam, Maria and Winkleby, Marilyn and Sundquist, Kristina and Kendler, Kenneth S and Crump, Casey}},
issn = {{1879-1379}},
keywords = {{Cohort study; Neighborhood SES; Internalizing and externalizing psychiatric disorders}},
language = {{eng}},
pages = {{7--15}},
publisher = {{Elsevier}},
series = {{Journal of Psychiatric Research}},
title = {{Familial and neighborhood effects on psychiatric disorders in childhood and adolescence}},
url = {{https://lup.lub.lu.se/search/files/2396651/8412082.pdf}},
doi = {{10.1016/j.jpsychires.2015.03.019}},
volume = {{66-67}},
year = {{2015}},
}