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Biphenotypic bigenotypic lymphoma with simultaneous expression of PAX5/BSAP and B- and T-cell markers

Hansson, Markus LU orcid ; Jerkeman, Mats LU and Dictor, Michael LU (2007) In European Journal of Haematology 79(2). p.159-165
Abstract
Lymphomas are currently categorized according to their origin from a B or T lymphocyte. Immature and less commonly mature (peripheral) lymphomas may harbor rearrangements of both the B- and T-cell antigen receptor genes (dual genotype or bigenotype). Rarely, cells in lymphoma with a single genotype simultaneously express both B- and T-cell markers (biphenotypic lymphomas). We discuss the diagnostic and clinical implications in the case of a 42-yr-old female with a peripheral CD30(+) lymphoma that displayed both characteristic B- and T-cell surface antigens and clonal rearrangement of B- and T-cell antigen receptor gene loci. Simultaneous nuclear expression of the transcription factor gene PAX5 suggested that this major driver of B-cell... (More)
Lymphomas are currently categorized according to their origin from a B or T lymphocyte. Immature and less commonly mature (peripheral) lymphomas may harbor rearrangements of both the B- and T-cell antigen receptor genes (dual genotype or bigenotype). Rarely, cells in lymphoma with a single genotype simultaneously express both B- and T-cell markers (biphenotypic lymphomas). We discuss the diagnostic and clinical implications in the case of a 42-yr-old female with a peripheral CD30(+) lymphoma that displayed both characteristic B- and T-cell surface antigens and clonal rearrangement of B- and T-cell antigen receptor gene loci. Simultaneous nuclear expression of the transcription factor gene PAX5 suggested that this major driver of B-cell differentiation did not preclude expression of CD3 epsilon, generally assumed to be a T-cell associated antigen. (Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
PAX5, biphenotypic, lymphoma, bigenotypic
in
European Journal of Haematology
volume
79
issue
2
pages
159 - 165
publisher
Wiley-Blackwell
external identifiers
  • wos:000248450800011
  • scopus:34447514182
  • pmid:17635241
ISSN
1600-0609
DOI
10.1111/j.1600-0609.2007.00882.x
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Hematology and Transfusion Medicine (013041100), Pathology, (Lund) (013030000), Oncology, MV (013035000)
id
c1df6f6a-65ad-4b99-9b3c-6b34f9b68619 (old id 686664)
date added to LUP
2016-04-01 11:39:48
date last changed
2025-10-14 13:30:30
@article{c1df6f6a-65ad-4b99-9b3c-6b34f9b68619,
  abstract     = {{Lymphomas are currently categorized according to their origin from a B or T lymphocyte. Immature and less commonly mature (peripheral) lymphomas may harbor rearrangements of both the B- and T-cell antigen receptor genes (dual genotype or bigenotype). Rarely, cells in lymphoma with a single genotype simultaneously express both B- and T-cell markers (biphenotypic lymphomas). We discuss the diagnostic and clinical implications in the case of a 42-yr-old female with a peripheral CD30(+) lymphoma that displayed both characteristic B- and T-cell surface antigens and clonal rearrangement of B- and T-cell antigen receptor gene loci. Simultaneous nuclear expression of the transcription factor gene PAX5 suggested that this major driver of B-cell differentiation did not preclude expression of CD3 epsilon, generally assumed to be a T-cell associated antigen.}},
  author       = {{Hansson, Markus and Jerkeman, Mats and Dictor, Michael}},
  issn         = {{1600-0609}},
  keywords     = {{PAX5; biphenotypic; lymphoma; bigenotypic}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{159--165}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{European Journal of Haematology}},
  title        = {{Biphenotypic bigenotypic lymphoma with simultaneous expression of PAX5/BSAP and B- and T-cell markers}},
  url          = {{http://dx.doi.org/10.1111/j.1600-0609.2007.00882.x}},
  doi          = {{10.1111/j.1600-0609.2007.00882.x}},
  volume       = {{79}},
  year         = {{2007}},
}