Vitronectin
Su, Yu Ching and Riesbeck, Kristian LU
(2017)
p.351-360
- Abstract
The multifaceted complement regulator vitronectin (Vn) can be found in almost all tissues of the human body. It is primarily produced by the liver and is thus detected at high concentrations in plasma. Upon inflammation, Vn is upregulated revealing its importance for the innate immune defence against danger signals. It consists of 459 amino acids and has several key sequences linked to its functions. Vn interacts at its N-terminal with plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor (uPAR). Downstream of these binding sites are sequences that attract integrins and collagen in addition to the thrombin-antithrombin III complex. Heme-binding plasma proteins, as well as plasminogen, can also interact with... (More)
The multifaceted complement regulator vitronectin (Vn) can be found in almost all tissues of the human body. It is primarily produced by the liver and is thus detected at high concentrations in plasma. Upon inflammation, Vn is upregulated revealing its importance for the innate immune defence against danger signals. It consists of 459 amino acids and has several key sequences linked to its functions. Vn interacts at its N-terminal with plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor (uPAR). Downstream of these binding sites are sequences that attract integrins and collagen in addition to the thrombin-antithrombin III complex. Heme-binding plasma proteins, as well as plasminogen, can also interact with Vn through heparin-binding domains. One of the main functions of Vn is to inhibit the terminal pathway of the complement system by preventing formation of the lethal pore-forming complex. This chapter will in detail discuss the knowledge on this important molecule.
(Less)
- author
- Su, Yu Ching
and Riesbeck, Kristian
LU
- organization
- publishing date
- 2017-10-19
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Cell adhesion, Complement regulator, Haemostasis, Heparin, Integrin, Multimeric, Plasminogen, Vitronectin
- host publication
- The Complement FactsBook : Second Edition - Second Edition
- pages
- 10 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85041270026
- ISBN
- 9780128104200
- DOI
- 10.1016/B978-0-12-810420-0.00033-X
- language
- English
- LU publication?
- yes
- id
- c210ca20-2425-4d7a-bf54-f10336580064
- date added to LUP
- 2018-02-12 14:23:12
- date last changed
- 2022-05-03 01:11:00
@inbook{c210ca20-2425-4d7a-bf54-f10336580064,
abstract = {{<p>The multifaceted complement regulator vitronectin (Vn) can be found in almost all tissues of the human body. It is primarily produced by the liver and is thus detected at high concentrations in plasma. Upon inflammation, Vn is upregulated revealing its importance for the innate immune defence against danger signals. It consists of 459 amino acids and has several key sequences linked to its functions. Vn interacts at its N-terminal with plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor (uPAR). Downstream of these binding sites are sequences that attract integrins and collagen in addition to the thrombin-antithrombin III complex. Heme-binding plasma proteins, as well as plasminogen, can also interact with Vn through heparin-binding domains. One of the main functions of Vn is to inhibit the terminal pathway of the complement system by preventing formation of the lethal pore-forming complex. This chapter will in detail discuss the knowledge on this important molecule.</p>}},
author = {{Su, Yu Ching and Riesbeck, Kristian}},
booktitle = {{The Complement FactsBook : Second Edition}},
isbn = {{9780128104200}},
keywords = {{Cell adhesion; Complement regulator; Haemostasis; Heparin; Integrin; Multimeric; Plasminogen; Vitronectin}},
language = {{eng}},
month = {{10}},
pages = {{351--360}},
publisher = {{Elsevier}},
title = {{Vitronectin}},
url = {{http://dx.doi.org/10.1016/B978-0-12-810420-0.00033-X}},
doi = {{10.1016/B978-0-12-810420-0.00033-X}},
year = {{2017}},
}