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An international multicenter retrospective analysis of patients with extranodal marginal zone lymphoma and histologically confirmed central nervous system and dural involvement

Sunderland, Andrew J. ; Steiner, Raphael E. ; Al Zahrani, Musa ; Pinnix, Chelsea C. ; Dabaja, Bouthaina Shbib ; Gunther, Jillian R. ; Nastoupil, Loretta J. ; Jerkeman, Mats LU ; Joske, David and Cull, Gavin , et al. (2020) In Cancer Medicine 9(2). p.663-670
Abstract

Marginal zone lymphoma of the central nervous system (CNS MZL) is rare. The clinical features, treatment, and prognosis are not well characterized. We performed a multicenter retrospective study of CNS MZL. Twenty-six patients were identified: half with primary and half with secondary CNS involvement. The median age was 59 years (range 26-78), 62% female and 79% with ECOG performance status ≤ 1. The most common disease site was the dura (50%). Treatment was determined by the treating physician and varied substantially. After a median follow up of 1.9 years, the estimated 2-year progression-free (PFS) and overall survival (OS) rates were 59% and 80%, respectively. Secondary CNS MZL was associated with 2-year OS of 58%. CNS MZL is rare,... (More)

Marginal zone lymphoma of the central nervous system (CNS MZL) is rare. The clinical features, treatment, and prognosis are not well characterized. We performed a multicenter retrospective study of CNS MZL. Twenty-six patients were identified: half with primary and half with secondary CNS involvement. The median age was 59 years (range 26-78), 62% female and 79% with ECOG performance status ≤ 1. The most common disease site was the dura (50%). Treatment was determined by the treating physician and varied substantially. After a median follow up of 1.9 years, the estimated 2-year progression-free (PFS) and overall survival (OS) rates were 59% and 80%, respectively. Secondary CNS MZL was associated with 2-year OS of 58%. CNS MZL is rare, but relative to other forms of CNS lymphoma, outcomes appear favorable, particularly among the subset of patients with dural presentation and primary CNS presentation.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CNS lymphoma, marginal zone lymphoma
in
Cancer Medicine
volume
9
issue
2
pages
8 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:31808316
  • scopus:85076264993
ISSN
2045-7634
DOI
10.1002/cam4.2732
language
English
LU publication?
yes
id
c260bfd1-0161-41f4-9eb1-ec9dda0a3672
date added to LUP
2021-01-07 13:32:13
date last changed
2024-04-17 22:41:19
@article{c260bfd1-0161-41f4-9eb1-ec9dda0a3672,
  abstract     = {{<p>Marginal zone lymphoma of the central nervous system (CNS MZL) is rare. The clinical features, treatment, and prognosis are not well characterized. We performed a multicenter retrospective study of CNS MZL. Twenty-six patients were identified: half with primary and half with secondary CNS involvement. The median age was 59 years (range 26-78), 62% female and 79% with ECOG performance status ≤ 1. The most common disease site was the dura (50%). Treatment was determined by the treating physician and varied substantially. After a median follow up of 1.9 years, the estimated 2-year progression-free (PFS) and overall survival (OS) rates were 59% and 80%, respectively. Secondary CNS MZL was associated with 2-year OS of 58%. CNS MZL is rare, but relative to other forms of CNS lymphoma, outcomes appear favorable, particularly among the subset of patients with dural presentation and primary CNS presentation.</p>}},
  author       = {{Sunderland, Andrew J. and Steiner, Raphael E. and Al Zahrani, Musa and Pinnix, Chelsea C. and Dabaja, Bouthaina Shbib and Gunther, Jillian R. and Nastoupil, Loretta J. and Jerkeman, Mats and Joske, David and Cull, Gavin and El-Galaly, Tarec and Villa, Diego and Cheah, Chan Yoon}},
  issn         = {{2045-7634}},
  keywords     = {{CNS lymphoma; marginal zone lymphoma}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{663--670}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Cancer Medicine}},
  title        = {{An international multicenter retrospective analysis of patients with extranodal marginal zone lymphoma and histologically confirmed central nervous system and dural involvement}},
  url          = {{http://dx.doi.org/10.1002/cam4.2732}},
  doi          = {{10.1002/cam4.2732}},
  volume       = {{9}},
  year         = {{2020}},
}