An observational analysis on the influence of parental allergic rhinitis, asthma and smoking on exhaled nitric oxide in offspring
(2024) In Nitric Oxide - Biology and Chemistry 149. p.60-66- Abstract
Background: Parental allergic diseases and smoking influence respiratory disease in the offspring but it is not known whether they influence fractional exhaled nitric oxide (FeNO) in the offspring. We investigated whether parental allergic diseases, parental smoking and FeNO levels in parents were associated with FeNO levels in their offspring. Methods: We studied 609 offspring aged 16–47 years from the Respiratory Health in Northern Europe, Spain and Australia generation (RHINESSA) study with parental information from the Respiratory Health in Northern Europe (RHINE) III study and the European Community Respiratory Health Survey (ECRHS) III. Linear regression models were used to assess the association between offspring FeNO and... (More)
Background: Parental allergic diseases and smoking influence respiratory disease in the offspring but it is not known whether they influence fractional exhaled nitric oxide (FeNO) in the offspring. We investigated whether parental allergic diseases, parental smoking and FeNO levels in parents were associated with FeNO levels in their offspring. Methods: We studied 609 offspring aged 16–47 years from the Respiratory Health in Northern Europe, Spain and Australia generation (RHINESSA) study with parental information from the Respiratory Health in Northern Europe (RHINE) III study and the European Community Respiratory Health Survey (ECRHS) III. Linear regression models were used to assess the association between offspring FeNO and parental FeNO, allergic rhinitis, asthma and smoking, while adjusting for potential confounding factors. Results: Parental allergic rhinitis was significantly associated with higher FeNO in the offspring, both on the paternal and maternal side (percent change: 20.3 % [95%CI 5.0–37.7], p = 0.008, and 13.8 % [0.4–28.9], p = 0.043, respectively). Parental allergic rhinitis with asthma in any parent was also significantly associated with higher offspring FeNO (16.2 % [0.9–33.9], p = 0.037). However, parental asthma alone and smoking were not associated with offspring FeNO. Parental FeNO was not associated with offspring FeNO after full adjustments for offspring and parental factors. Conclusions: Parental allergic rhinitis but not parental asthma was associated with higher levels of FeNO in offspring. These findings suggest that parental allergic rhinitis status should be considered when interpreting FeNO levels in offspring beyond childhood.
(Less)
- author
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Allergic rhinitis, Asthma, FeNO, Offspring, Parental allergic disease
- in
- Nitric Oxide - Biology and Chemistry
- volume
- 149
- pages
- 7 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85196157259
- pmid:38876398
- ISSN
- 1089-8603
- DOI
- 10.1016/j.niox.2024.06.001
- language
- English
- LU publication?
- yes
- id
- c2756456-16a0-40a8-b5ae-75131705893f
- date added to LUP
- 2024-07-03 11:16:24
- date last changed
- 2024-07-03 11:16:51
@article{c2756456-16a0-40a8-b5ae-75131705893f,
abstract = {{<p>Background: Parental allergic diseases and smoking influence respiratory disease in the offspring but it is not known whether they influence fractional exhaled nitric oxide (FeNO) in the offspring. We investigated whether parental allergic diseases, parental smoking and FeNO levels in parents were associated with FeNO levels in their offspring. Methods: We studied 609 offspring aged 16–47 years from the Respiratory Health in Northern Europe, Spain and Australia generation (RHINESSA) study with parental information from the Respiratory Health in Northern Europe (RHINE) III study and the European Community Respiratory Health Survey (ECRHS) III. Linear regression models were used to assess the association between offspring FeNO and parental FeNO, allergic rhinitis, asthma and smoking, while adjusting for potential confounding factors. Results: Parental allergic rhinitis was significantly associated with higher FeNO in the offspring, both on the paternal and maternal side (percent change: 20.3 % [95%CI 5.0–37.7], p = 0.008, and 13.8 % [0.4–28.9], p = 0.043, respectively). Parental allergic rhinitis with asthma in any parent was also significantly associated with higher offspring FeNO (16.2 % [0.9–33.9], p = 0.037). However, parental asthma alone and smoking were not associated with offspring FeNO. Parental FeNO was not associated with offspring FeNO after full adjustments for offspring and parental factors. Conclusions: Parental allergic rhinitis but not parental asthma was associated with higher levels of FeNO in offspring. These findings suggest that parental allergic rhinitis status should be considered when interpreting FeNO levels in offspring beyond childhood.</p>}},
author = {{Zaigham, S. and Bertelsen, R. J. and Dharmage, S. C. and Schlünssen, V. and Jögi, N. O. and Gomez, L. Palacios and Holm, M. and Oudin, A. and Abramson, M. J. and Sigsgaard, T. and Jõgi, R. and Svanes, C. and Olin, A. C. and Forsberg, B. and Janson, C. and Nerpin, E. and Johannessen, A. and Malinovschi, A.}},
issn = {{1089-8603}},
keywords = {{Allergic rhinitis; Asthma; FeNO; Offspring; Parental allergic disease}},
language = {{eng}},
pages = {{60--66}},
publisher = {{Elsevier}},
series = {{Nitric Oxide - Biology and Chemistry}},
title = {{An observational analysis on the influence of parental allergic rhinitis, asthma and smoking on exhaled nitric oxide in offspring}},
url = {{http://dx.doi.org/10.1016/j.niox.2024.06.001}},
doi = {{10.1016/j.niox.2024.06.001}},
volume = {{149}},
year = {{2024}},
}