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Investigation of obesity candidate genes on porcine fat deposition quantitative trait loci regions

Kim, Kwan Suk ; Thomsen, Hauke LU orcid ; Bastiaanse, John ; Thu Nguyen, Nguyet ; Dekkers, Jack C.M. ; Plastow, Graham S. and Rothschild, Max F. (2004) In Obesity Research 12(12). p.1981-1994
Abstract

Objectives: To investigate possible obesity candidate genes in regions of porcine quantitative trait loci (QTL) for fat deposition and obesity-related phenotypes. Research Methods and Procedures: Chromosome mapping and QTL analyses of obesity candidate genes were performed using DNA panels from a reference pig family. Statistical association analyses of these genes were performed for fat deposition phenotypes in several other commercial pig populations. Results: Eight candidate genes were mapped to QTL regions of pig chromosomes in this study. These candidate genes also served as anchor loci to determine homologous human chromosomal locations of pig fat deposition QTL. Preliminary analyses of relationships among polymorphisms of... (More)

Objectives: To investigate possible obesity candidate genes in regions of porcine quantitative trait loci (QTL) for fat deposition and obesity-related phenotypes. Research Methods and Procedures: Chromosome mapping and QTL analyses of obesity candidate genes were performed using DNA panels from a reference pig family. Statistical association analyses of these genes were performed for fat deposition phenotypes in several other commercial pig populations. Results: Eight candidate genes were mapped to QTL regions of pig chromosomes in this study. These candidate genes also served as anchor loci to determine homologous human chromosomal locations of pig fat deposition QTL. Preliminary analyses of relationships among polymorphisms of individual candidate genes and a variety of phenotypic measurements in a large number of pigs were performed. On the basis of available data, gene-gene interactions were also studied. Discussion: Comparative analysis of obesity-related genes in the pig is not only important for development of markerassisted selection on growth and fat deposition traits in the pig but also provides for an understanding of their genetic roles in the development of human obesity.

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author
; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Animal model, Candidate genes, Fat deposition in pigs, Human obesity, Quantitative trait loci
in
Obesity Research
volume
12
issue
12
pages
14 pages
publisher
Nature Publishing Group
external identifiers
  • pmid:15687400
  • scopus:18944389986
ISSN
1071-7323
DOI
10.1038/oby.2004.249
language
English
LU publication?
no
id
c27b9a57-af53-4107-b4b7-4ed8a0a503cd
date added to LUP
2018-10-10 13:35:34
date last changed
2024-03-16 02:53:19
@article{c27b9a57-af53-4107-b4b7-4ed8a0a503cd,
  abstract     = {{<p>Objectives: To investigate possible obesity candidate genes in regions of porcine quantitative trait loci (QTL) for fat deposition and obesity-related phenotypes. Research Methods and Procedures: Chromosome mapping and QTL analyses of obesity candidate genes were performed using DNA panels from a reference pig family. Statistical association analyses of these genes were performed for fat deposition phenotypes in several other commercial pig populations. Results: Eight candidate genes were mapped to QTL regions of pig chromosomes in this study. These candidate genes also served as anchor loci to determine homologous human chromosomal locations of pig fat deposition QTL. Preliminary analyses of relationships among polymorphisms of individual candidate genes and a variety of phenotypic measurements in a large number of pigs were performed. On the basis of available data, gene-gene interactions were also studied. Discussion: Comparative analysis of obesity-related genes in the pig is not only important for development of markerassisted selection on growth and fat deposition traits in the pig but also provides for an understanding of their genetic roles in the development of human obesity.</p>}},
  author       = {{Kim, Kwan Suk and Thomsen, Hauke and Bastiaanse, John and Thu Nguyen, Nguyet and Dekkers, Jack C.M. and Plastow, Graham S. and Rothschild, Max F.}},
  issn         = {{1071-7323}},
  keywords     = {{Animal model; Candidate genes; Fat deposition in pigs; Human obesity; Quantitative trait loci}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{12}},
  pages        = {{1981--1994}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Obesity Research}},
  title        = {{Investigation of obesity candidate genes on porcine fat deposition quantitative trait loci regions}},
  url          = {{http://dx.doi.org/10.1038/oby.2004.249}},
  doi          = {{10.1038/oby.2004.249}},
  volume       = {{12}},
  year         = {{2004}},
}