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Maternal dietary supplement use and development of islet autoimmunity in the offspring : TEDDY study

, ; Silvis, Katherine; Aronsson, Carin A. LU ; Liu, Xiang; Uusitalo, Ulla; Yang, Jimin; Tamura, Roy; Lernmark, Åke LU ; Rewers, Marian and Hagopian, William, et al. (2018) In Pediatric Diabetes
Abstract

Objective: We investigated the association between maternal use of vitamin D and omega-3 fatty acids (n-3 FAs) supplements during pregnancy and risk of islet autoimmunity (IA) in the offspring. Methods: The Environmental Determinants of Diabetes in the Young (TEDDY) Study is prospectively following 8676 children with increased genetic risk for type 1 diabetes in Finland, Germany, Sweden, and the United States. Blood samples were collected every 3 months between 3 and 48 months of age then every 6 months thereafter to determine persistent IA. Duration, frequency, and supplement dose during pregnancy were recalled by mothers at 3 to 4 months postpartum. Cumulative intakes of supplemental vitamin D and n-3 FAs were analyzed as continuous... (More)

Objective: We investigated the association between maternal use of vitamin D and omega-3 fatty acids (n-3 FAs) supplements during pregnancy and risk of islet autoimmunity (IA) in the offspring. Methods: The Environmental Determinants of Diabetes in the Young (TEDDY) Study is prospectively following 8676 children with increased genetic risk for type 1 diabetes in Finland, Germany, Sweden, and the United States. Blood samples were collected every 3 months between 3 and 48 months of age then every 6 months thereafter to determine persistent IA. Duration, frequency, and supplement dose during pregnancy were recalled by mothers at 3 to 4 months postpartum. Cumulative intakes of supplemental vitamin D and n-3 FAs were analyzed as continuous or binary variables. We applied time-to-event analysis to study the association between maternal supplement use and IA, adjusting for country, human leukocyte antigen-DR-DQ genotype, family history of type 1 diabetes and sex. Secondary outcomes included insulin autoantibodies (IAA) or glutamic acid decarboxylase (GADA) as the first appearing autoantibody. Results: As of February 2018, there were 747 (9.0%) children with IA. Vitamin D supplement intake during pregnancy (any vs none) was not associated with risk for IA (hazard ratio [HR] 1.11; 95% confidence interval [CI] 0.94, 1.31); neither was cumulative vitamin D supplement intake. Supplemental n-3 FA intake was similarly not associated with IA risk (HR: 1.19, 95% CI 0.98, 1.45). Similar lack of association was observed for either IAA or GADA as the first appearing autoantibody. Conclusions: The TEDDY cohort showed no evidence of benefit regarding IA risk for vitamin D or n-3 FA supplementation during pregnancy.

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publication status
epub
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keywords
dietary supplements, islet autoimmunity, omega-3 fatty acids, pregnancy, vitamin D
in
Pediatric Diabetes
publisher
Wiley-Blackwell
external identifiers
  • scopus:85058048564
ISSN
1399-543X
DOI
10.1111/pedi.12794
language
English
LU publication?
yes
id
c2ecee56-125b-4b13-9cb2-637b51284dd7
date added to LUP
2019-01-08 10:56:18
date last changed
2019-08-14 04:30:14
@article{c2ecee56-125b-4b13-9cb2-637b51284dd7,
  abstract     = {<p>Objective: We investigated the association between maternal use of vitamin D and omega-3 fatty acids (n-3 FAs) supplements during pregnancy and risk of islet autoimmunity (IA) in the offspring. Methods: The Environmental Determinants of Diabetes in the Young (TEDDY) Study is prospectively following 8676 children with increased genetic risk for type 1 diabetes in Finland, Germany, Sweden, and the United States. Blood samples were collected every 3 months between 3 and 48 months of age then every 6 months thereafter to determine persistent IA. Duration, frequency, and supplement dose during pregnancy were recalled by mothers at 3 to 4 months postpartum. Cumulative intakes of supplemental vitamin D and n-3 FAs were analyzed as continuous or binary variables. We applied time-to-event analysis to study the association between maternal supplement use and IA, adjusting for country, human leukocyte antigen-DR-DQ genotype, family history of type 1 diabetes and sex. Secondary outcomes included insulin autoantibodies (IAA) or glutamic acid decarboxylase (GADA) as the first appearing autoantibody. Results: As of February 2018, there were 747 (9.0%) children with IA. Vitamin D supplement intake during pregnancy (any vs none) was not associated with risk for IA (hazard ratio [HR] 1.11; 95% confidence interval [CI] 0.94, 1.31); neither was cumulative vitamin D supplement intake. Supplemental n-3 FA intake was similarly not associated with IA risk (HR: 1.19, 95% CI 0.98, 1.45). Similar lack of association was observed for either IAA or GADA as the first appearing autoantibody. Conclusions: The TEDDY cohort showed no evidence of benefit regarding IA risk for vitamin D or n-3 FA supplementation during pregnancy.</p>},
  author       = {,  and Silvis, Katherine and Aronsson, Carin A. and Liu, Xiang and Uusitalo, Ulla and Yang, Jimin and Tamura, Roy and Lernmark, Åke and Rewers, Marian and Hagopian, William and She, Jin Xiong and Simell, Olli and Toppari, Jorma and Ziegler, Anette and Akolkar, Beena and Krischer, Jeffrey and Virtanen, Suvi M. and Norris, Jill M.},
  issn         = {1399-543X},
  keyword      = {dietary supplements,islet autoimmunity,omega-3 fatty acids,pregnancy,vitamin D},
  language     = {eng},
  month        = {11},
  publisher    = {Wiley-Blackwell},
  series       = {Pediatric Diabetes},
  title        = {Maternal dietary supplement use and development of islet autoimmunity in the offspring : TEDDY study},
  url          = {http://dx.doi.org/10.1111/pedi.12794},
  year         = {2018},
}