Neuropeptide levels in Alzheimer's disease and dementia with frontotemporal degeneration
(1990) In Journal of neural transmission. Supplementum 30. p.57-67- Abstract
- The CSF levels of somatostatin-LI (SLI), neuropeptide Y (NPY-LI) and Delta Sleep Inducing Peptide (DSIP-LI) have been measured in patients with dementia of Alzheimer type (DAT) and dementia with frontotemporal degeneration of non-Alzheimer type (FTD). The distribution pattern of cortical degeneration differs between these two types of dementia. DAT shows degeneration of mainly temporo-parietal and temporo-limbic structures, whereas FTD discloses its main degeneration in the frontotemporal regions (Brun, 1987). The somatostatin-LI was significantly reduced both in DAT and FTD. NPY-LI showed a significant reduction in DAT but not in FTD. A tendency to a reduction with duration of the disease was observed in DAT whereas the contrary was noted... (More)
- The CSF levels of somatostatin-LI (SLI), neuropeptide Y (NPY-LI) and Delta Sleep Inducing Peptide (DSIP-LI) have been measured in patients with dementia of Alzheimer type (DAT) and dementia with frontotemporal degeneration of non-Alzheimer type (FTD). The distribution pattern of cortical degeneration differs between these two types of dementia. DAT shows degeneration of mainly temporo-parietal and temporo-limbic structures, whereas FTD discloses its main degeneration in the frontotemporal regions (Brun, 1987). The somatostatin-LI was significantly reduced both in DAT and FTD. NPY-LI showed a significant reduction in DAT but not in FTD. A tendency to a reduction with duration of the disease was observed in DAT whereas the contrary was noted in FTD. The DSIP-LI levels were reduced in DAT and slightly increased in FTD. The study provides an evidence of neurochemical differences between the two primary degenerative dementias. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1296189
- author
- Minthon, Lennart LU ; Edvinsson, Lars LU ; Ekman, R and Gustafson, Lars LU
- organization
- publishing date
- 1990
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of neural transmission. Supplementum
- volume
- 30
- pages
- 57 - 67
- publisher
- Springer
- external identifiers
-
- scopus:0025035230
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Faculty of Medicine (000022000), Clinical Memory Research Unit (013242610), Medicine (Lund) (013230025), Department of Psychogeriatrics (013304000)
- id
- c31f3951-0715-4fc3-bc75-9c1a6ee4766b (old id 1296189)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed?term=1975266
- date added to LUP
- 2016-04-04 13:53:49
- date last changed
- 2024-01-13 10:05:34
@article{c31f3951-0715-4fc3-bc75-9c1a6ee4766b, abstract = {{The CSF levels of somatostatin-LI (SLI), neuropeptide Y (NPY-LI) and Delta Sleep Inducing Peptide (DSIP-LI) have been measured in patients with dementia of Alzheimer type (DAT) and dementia with frontotemporal degeneration of non-Alzheimer type (FTD). The distribution pattern of cortical degeneration differs between these two types of dementia. DAT shows degeneration of mainly temporo-parietal and temporo-limbic structures, whereas FTD discloses its main degeneration in the frontotemporal regions (Brun, 1987). The somatostatin-LI was significantly reduced both in DAT and FTD. NPY-LI showed a significant reduction in DAT but not in FTD. A tendency to a reduction with duration of the disease was observed in DAT whereas the contrary was noted in FTD. The DSIP-LI levels were reduced in DAT and slightly increased in FTD. The study provides an evidence of neurochemical differences between the two primary degenerative dementias.}}, author = {{Minthon, Lennart and Edvinsson, Lars and Ekman, R and Gustafson, Lars}}, language = {{eng}}, pages = {{57--67}}, publisher = {{Springer}}, series = {{Journal of neural transmission. Supplementum}}, title = {{Neuropeptide levels in Alzheimer's disease and dementia with frontotemporal degeneration}}, url = {{http://www.ncbi.nlm.nih.gov/pubmed?term=1975266}}, volume = {{30}}, year = {{1990}}, }