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Effect of Cimetidine on Survival after gastric cancer

Tonnesen, Hanne LU ; Bülow, Steffen ; Fischerman, Kaj ; Hjortrup, Allan ; Møller Pedersen, Vilhelm ; Bo Svendsen, Lars ; Knigge, Ulrich ; Damm, Peter ; Hesselfeldt, Peter and Krogh Pedersen, Ib , et al. (1988) In The Lancet 332(8618). p.990-992
Abstract

The effect of cimetidine on survival was investigated in 181 patients with gastric cancer. Immediately after operation or the decision not to operate, the patients were randomised in double-blind fashion to placebo or cimetidine 400 mg twice daily for two years or until death, with review every three months. Median survival in the cimetidine group was 450 days (range 1-1826) and in the placebo group 316 days (1-1653). The relative survival rates (cimetidine/placebo) were 45%/28% at 1 year, 22%/13% at 2 years, 13%/7% at 3 years, 9%/3% at 4 years, and 2%/0% at 5 years. Survival in the cimetidine group was significantly longer than in the placebo group.

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publishing date
type
Contribution to journal
publication status
published
subject
in
The Lancet
volume
332
issue
8618
pages
3 pages
publisher
Elsevier
external identifiers
  • scopus:0023816023
  • pmid:2902494
ISSN
0140-6736
DOI
10.1016/S0140-6736(88)90743-X
language
English
LU publication?
no
id
c32e6e05-156d-4271-a5e2-144ac26da392
date added to LUP
2018-11-01 14:08:04
date last changed
2024-04-15 16:52:46
@article{c32e6e05-156d-4271-a5e2-144ac26da392,
  abstract     = {{<p>The effect of cimetidine on survival was investigated in 181 patients with gastric cancer. Immediately after operation or the decision not to operate, the patients were randomised in double-blind fashion to placebo or cimetidine 400 mg twice daily for two years or until death, with review every three months. Median survival in the cimetidine group was 450 days (range 1-1826) and in the placebo group 316 days (1-1653). The relative survival rates (cimetidine/placebo) were 45%/28% at 1 year, 22%/13% at 2 years, 13%/7% at 3 years, 9%/3% at 4 years, and 2%/0% at 5 years. Survival in the cimetidine group was significantly longer than in the placebo group.</p>}},
  author       = {{Tonnesen, Hanne and Bülow, Steffen and Fischerman, Kaj and Hjortrup, Allan and Møller Pedersen, Vilhelm and Bo Svendsen, Lars and Knigge, Ulrich and Damm, Peter and Hesselfeldt, Peter and Krogh Pedersen, Ib and Julius Siemssen, Ole and Martin Christiansen, Poul}},
  issn         = {{0140-6736}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{8618}},
  pages        = {{990--992}},
  publisher    = {{Elsevier}},
  series       = {{The Lancet}},
  title        = {{Effect of Cimetidine on Survival after gastric cancer}},
  url          = {{http://dx.doi.org/10.1016/S0140-6736(88)90743-X}},
  doi          = {{10.1016/S0140-6736(88)90743-X}},
  volume       = {{332}},
  year         = {{1988}},
}