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Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia

Vijayakrishnan, Jayaram; Studd, James; Broderick, Peter; Kinnersley, Ben; Holroyd, Amy; Law, Philip J.; Kumar, Rajiv; Allan, James M.; Harrison, Christine J. and Moorman, Anthony V., et al. (2018) In Nature Communications 9(1).
Abstract

Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10-8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.

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Nature Communications
volume
9
issue
1
publisher
Nature Publishing Group
external identifiers
  • scopus:85045221334
ISSN
2041-1723
DOI
10.1038/s41467-018-03178-z
language
English
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yes
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c3cf8682-329f-4cd4-b8d3-e6ab969636c6
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2018-04-18 07:12:50
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2019-04-10 04:06:52
@article{c3cf8682-329f-4cd4-b8d3-e6ab969636c6,
  abstract     = {<p>Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10<sup>-9</sup>, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10<sup>-8</sup>, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.</p>},
  articleno    = {1340},
  author       = {Vijayakrishnan, Jayaram and Studd, James and Broderick, Peter and Kinnersley, Ben and Holroyd, Amy and Law, Philip J. and Kumar, Rajiv and Allan, James M. and Harrison, Christine J. and Moorman, Anthony V. and Vora, Ajay and Roman, Eve and Rachakonda, Sivaramakrishna and Kinsey, Sally E. and Sheridan, Eamonn and Thompson, Pamela D. and Irving, Julie A. and Koehler, Rolf and Hoffmann, Per and Nöthen, Markus M. and Heilmann-Heimbach, Stefanie and Jöckel, Karl Heinz and Easton, Douglas F. and Pharaoh, Paul D.P. and Dunning, Alison M. and Peto, Julian and Canzian, Frederico and Swerdlow, Anthony and Eeles, Rosalind A. and Kote-Jarai, ZSofia and Muir, Kenneth and Pashayan, Nora and Greaves, Mel and Zimmerman, Martin and Bartram, Claus R. and Schrappe, Martin and Stanulla, Martin and Hemminki, Kari and Houlston, Richard S. and , },
  issn         = {2041-1723},
  language     = {eng},
  month        = {12},
  number       = {1},
  publisher    = {Nature Publishing Group},
  series       = {Nature Communications},
  title        = {Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia},
  url          = {http://dx.doi.org/10.1038/s41467-018-03178-z},
  volume       = {9},
  year         = {2018},
}