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Conclusiveness resolves the conflict between quality of evidence and imprecision in GRADE

Anttila, Sten; Persson, Johannes LU ; Vareman, Niklas LU and Sahlin, Nils-Eric LU (2016) In Journal of Clinical Epidemiology 2016(75). p.1-5
Abstract (Swedish)
Objectives
The objective of our article is to show how “quality of evidence” and “imprecision,” as they are defined in Grading of Recommendations Assessment, Development, and Evaluation (GRADE) articles, may lead to confusion. We focus only on the context of systematic reviews.

Study Design and Setting
We analyze, with the aid of standard probabilistic and statistical concepts, the concepts of quality of evidence and imprecision as used in the GRADE framework. This enables us to point out some weaknesses in the relation between “quality of evidence” and “imprecision.”

Results
The GRADE framework contains terms familiar from classical statistics, but these terms are used in nonstandard ways. Notably,... (More)
Objectives
The objective of our article is to show how “quality of evidence” and “imprecision,” as they are defined in Grading of Recommendations Assessment, Development, and Evaluation (GRADE) articles, may lead to confusion. We focus only on the context of systematic reviews.

Study Design and Setting
We analyze, with the aid of standard probabilistic and statistical concepts, the concepts of quality of evidence and imprecision as used in the GRADE framework. This enables us to point out some weaknesses in the relation between “quality of evidence” and “imprecision.”

Results
The GRADE framework contains terms familiar from classical statistics, but these terms are used in nonstandard ways. Notably, “imprecision” does not have the meaning in the GRADE framework that it has in statistics, and the well-known table of “evidence levels” wrongly suggests that “quality of evidence” and “accuracy” express the same concept—they do not.

Conclusion
We believe that “conclusiveness” rather than “imprecision” would be a suitable term to use when the question whether the CI excludes or includes certain critical margins is being addressed. Conclusiveness could also replace quality of evidence as the final step for a systematic reviewer. (Less)
Abstract
The objective of our article is to show how “quality of evidence” and “imprecision,” as they are defined in Grading of Recommendations Assessment, Development, and Evaluation (GRADE) articles, may lead to confusion. We focus only on the context of systematic reviews.
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author
organization
alternative title
Conclusiveness resolves the conflict between quality of evidence and imprecision in GRADE
publishing date
type
Contribution to journal
publication status
published
subject
keywords
GRADE, Imprecision, Conclusiveness, Accuracy, Confidence in estimate, Quality of evidence
in
Journal of Clinical Epidemiology
volume
2016
issue
75
pages
5 pages
publisher
Elsevier
external identifiers
  • scopus:84964856595
  • wos:000378976300002
ISSN
1878-5921
DOI
10.1016/j.jclinepi.2016.03.019
language
English
LU publication?
yes
id
c414e9cf-fc26-4f64-b42d-f4f9859f99c6
date added to LUP
2016-05-13 09:02:14
date last changed
2017-01-01 08:25:50
@article{c414e9cf-fc26-4f64-b42d-f4f9859f99c6,
  abstract     = {The objective of our article is to show how “quality of evidence” and “imprecision,” as they are defined in Grading of Recommendations Assessment, Development, and Evaluation (GRADE) articles, may lead to confusion. We focus only on the context of systematic reviews.},
  articleno    = {JCE9148},
  author       = {Anttila, Sten and Persson, Johannes and Vareman, Niklas and Sahlin, Nils-Eric},
  issn         = {1878-5921},
  keyword      = {GRADE,Imprecision,Conclusiveness,Accuracy,Confidence in estimate,Quality of evidence},
  language     = {eng},
  month        = {06},
  number       = {75},
  pages        = {1--5},
  publisher    = {Elsevier},
  series       = {Journal of Clinical Epidemiology},
  title        = {Conclusiveness resolves the conflict between quality of evidence and imprecision in GRADE},
  url          = {http://dx.doi.org/10.1016/j.jclinepi.2016.03.019},
  volume       = {2016},
  year         = {2016},
}