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Revealing genes associated with cervical cancer in distinct immune cells : A comprehensive Mendelian randomization analysis

Li, Ning ; Yi, Huan LU ; Sun, Wen ; Sundquist, Jan LU ; Sundquist, Kristina LU ; Zhang, Xiaoyu ; Zheng, Deqiang LU and Ji, Jianguang LU orcid (2024) In International Journal of Cancer
Abstract

Human papillomavirus can be contracted by sexually active women. However, only a small proportion of these infections persist and have the potential to progress into cervical cancers, indicating a significant involvement of the immune system in cervical cancer development. Despite this, our understanding of the precise contributions of genes from different immune cell types in cervical cancers remains limited. Therefore, the primary objective of our study was to investigate the potential causal relationships between specific immune cell genes and the development of cervical cancers. By accessing expression quantitative trait loci datasets of 14 distinct immune cell types and genome wide association study of cervical cancers, we employed... (More)

Human papillomavirus can be contracted by sexually active women. However, only a small proportion of these infections persist and have the potential to progress into cervical cancers, indicating a significant involvement of the immune system in cervical cancer development. Despite this, our understanding of the precise contributions of genes from different immune cell types in cervical cancers remains limited. Therefore, the primary objective of our study was to investigate the potential causal relationships between specific immune cell genes and the development of cervical cancers. By accessing expression quantitative trait loci datasets of 14 distinct immune cell types and genome wide association study of cervical cancers, we employed the summary data-based Mendelian randomization (SMR) along with multi-single nucleotide polymorphism (SNP)-based SMR to identify significant genes associated with cervical cancers. Colocalization analysis was further conducted to explore the shared genetic causality. A total of 10 genes across 11 immune cell types (26 significant gene-trait associations) were found to be associated with cervical cancers after false discovery rate correction. Notably, the ORMDL3, BRK1 and HMGN1 gene expression levels showed significant association with cervical cancer in specific immune cell types, respectively. These associations were supported by strong evidence of colocalization analyses. Our study has identified several genes in different immune cells that were associated with cervical cancer. However, further research is necessary to confirm these findings and provide more comprehensive insights into the association between these gene expressions and cervical cancer risk.

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author
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organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
International Journal of Cancer
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85187170968
  • pmid:38447016
ISSN
0020-7136
DOI
10.1002/ijc.34911
language
English
LU publication?
yes
id
c41afb52-295e-4758-aa08-2fdc18c07be4
date added to LUP
2024-03-10 12:07:21
date last changed
2024-04-16 12:36:14
@article{c41afb52-295e-4758-aa08-2fdc18c07be4,
  abstract     = {{<p>Human papillomavirus can be contracted by sexually active women. However, only a small proportion of these infections persist and have the potential to progress into cervical cancers, indicating a significant involvement of the immune system in cervical cancer development. Despite this, our understanding of the precise contributions of genes from different immune cell types in cervical cancers remains limited. Therefore, the primary objective of our study was to investigate the potential causal relationships between specific immune cell genes and the development of cervical cancers. By accessing expression quantitative trait loci datasets of 14 distinct immune cell types and genome wide association study of cervical cancers, we employed the summary data-based Mendelian randomization (SMR) along with multi-single nucleotide polymorphism (SNP)-based SMR to identify significant genes associated with cervical cancers. Colocalization analysis was further conducted to explore the shared genetic causality. A total of 10 genes across 11 immune cell types (26 significant gene-trait associations) were found to be associated with cervical cancers after false discovery rate correction. Notably, the ORMDL3, BRK1 and HMGN1 gene expression levels showed significant association with cervical cancer in specific immune cell types, respectively. These associations were supported by strong evidence of colocalization analyses. Our study has identified several genes in different immune cells that were associated with cervical cancer. However, further research is necessary to confirm these findings and provide more comprehensive insights into the association between these gene expressions and cervical cancer risk.</p>}},
  author       = {{Li, Ning and Yi, Huan and Sun, Wen and Sundquist, Jan and Sundquist, Kristina and Zhang, Xiaoyu and Zheng, Deqiang and Ji, Jianguang}},
  issn         = {{0020-7136}},
  language     = {{eng}},
  month        = {{03}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Revealing genes associated with cervical cancer in distinct immune cells : A comprehensive Mendelian randomization analysis}},
  url          = {{http://dx.doi.org/10.1002/ijc.34911}},
  doi          = {{10.1002/ijc.34911}},
  year         = {{2024}},
}