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Erythropoietin and desmopressin obviated transfusion in a thromboasthenic Jehovah's Witness undergoing scoliosis surgery

Lethagen, Stefan LU and Karlsson, Magnus K. LU (1996) In Clinical and Applied Thrombosis/Hemostasis 2(1). p.11-13
Abstract

A 13-year-old female Jehovah's Witness with thromboasthenia was scheduled for scoliosis surgery. To reduce the risk of heterologous transfusion, she was given erythropoietin for 2 weeks preoperatively. Bleeding time and platelet dysfunction normalized during erythropoietin treatment, but the hemoglobin concentration increased only marginally. Desmopressin and tranexamic acid were given as cover for surgery. Blood loss was less than that in the average scoliosis patient, 1,490 ml as compared to 2,740 ml, and no heterologous transfusion was given. Erythropoietin may thus be given preoperatively, not only to increase the hemoglobin concentration, but also to improve the platelet function in thromboasthenic patients.

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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Erythropoietin, Jehovah's Witness, Thromboasthenia
in
Clinical and Applied Thrombosis/Hemostasis
volume
2
issue
1
pages
11 - 13
publisher
SAGE Publications
external identifiers
  • scopus:24044503782
ISSN
1076-0296
DOI
10.1177/107602969600200103
language
English
LU publication?
yes
id
c42bea3d-113f-41b3-b091-055824996bf2
date added to LUP
2019-05-21 19:29:52
date last changed
2024-01-01 06:26:04
@article{c42bea3d-113f-41b3-b091-055824996bf2,
  abstract     = {{<p>A 13-year-old female Jehovah's Witness with thromboasthenia was scheduled for scoliosis surgery. To reduce the risk of heterologous transfusion, she was given erythropoietin for 2 weeks preoperatively. Bleeding time and platelet dysfunction normalized during erythropoietin treatment, but the hemoglobin concentration increased only marginally. Desmopressin and tranexamic acid were given as cover for surgery. Blood loss was less than that in the average scoliosis patient, 1,490 ml as compared to 2,740 ml, and no heterologous transfusion was given. Erythropoietin may thus be given preoperatively, not only to increase the hemoglobin concentration, but also to improve the platelet function in thromboasthenic patients.</p>}},
  author       = {{Lethagen, Stefan and Karlsson, Magnus K.}},
  issn         = {{1076-0296}},
  keywords     = {{Erythropoietin; Jehovah's Witness; Thromboasthenia}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{11--13}},
  publisher    = {{SAGE Publications}},
  series       = {{Clinical and Applied Thrombosis/Hemostasis}},
  title        = {{Erythropoietin and desmopressin obviated transfusion in a thromboasthenic Jehovah's Witness undergoing scoliosis surgery}},
  url          = {{http://dx.doi.org/10.1177/107602969600200103}},
  doi          = {{10.1177/107602969600200103}},
  volume       = {{2}},
  year         = {{1996}},
}